β-Apo-oxytetracycline
- CAS No.
- 18751-99-0
- Chemical Name:
- β-Apo-oxytetracycline
- Synonyms
- β-Apooxytetracycline;b-Apo-oxytetracycline;β-Apo-oxytetracycline;BETA-APO-OXYTETRACYCLINE;Apooxytetracycline, beta-;ALPHA-APO-OXYTETRACYCLINE;Oxytetracycline Impurity E;β-Apo-oxytetracycline, >85%;β-Apo-oxytetracycline (>80%);Oxytetracycline EP Impurity E
- CBNumber:
- CB9455892
- Molecular Formula:
- C22H22N2O8
- Molecular Weight:
- 442.42
- MDL Number:
- MFCD00062827
- MOL File:
- 18751-99-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 200-204 °C |
|---|---|
| Boiling point | 742.4±60.0 °C(Predicted) |
| Density | 1.62±0.1 g/cm3(Predicted) |
| storage temp. | Refrigerator, Under Inert Atmosphere |
| solubility | Aqueous Base (Slightly), Methanol (Slightly, Heated, Sonicated) |
| pka | 1.62±0.58(Predicted) |
| form | Powder |
| color | Yellow-brown to brown |
| Stability | Unstable in basic solution |
| InChIKey | DRKMHDAKULCOKQ-VUPCMTQJSA-N |
| SMILES | C1(C(N)=O)C(=O)[C@H](O)[C@@H](C2C3=C(C)C4C(=C(O)C=CC=4)C(O)=C3C(=O)O2)[C@@H](N(C)C)C=1O |
| FDA UNII | 7HSY5812F9 |
| EPA Substance Registry System | 1-Cyclohexene-1-carboxamide, 4-(1,3-dihydro-4,5-dihydroxy-9-methyl-3-oxonaphtho[2,3-c]furan-1-yl)-3-(dimethylamino)-2,5-dihydroxy-6-oxo- (18751-99-0) |
β-Apo-oxytetracycline price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 27099 | β-Apooxytetracycline ≥98% | 18751-99-0 | 500μg | $44 | 2026-04-30 | Buy |
| Cayman Chemical | 27099 | β-Apooxytetracycline ≥98% | 18751-99-0 | 1mg | $84 | 2026-04-30 | Buy |
| Cayman Chemical | 27099 | β-Apooxytetracycline ≥98% | 18751-99-0 | 5mg | $344 | 2026-04-30 | Buy |
| Cayman Chemical | 27099 | β-Apooxytetracycline ≥98% | 18751-99-0 | 10mg | $642 | 2026-04-30 | Buy |
| Usbiological | 002804 | β-Apo-oxytetracycline ≥85%(TLC) | 18751-99-0 | 1mg | $460 | 2026-06-03 | Buy |
β-Apo-oxytetracycline Chemical Properties, Uses, Production
Description
β-Apooxytetracycline is a potential impurity found in commercial preparations of oxytetracycline. β-Apooxytetracycline is a degradation product formed from oxytetracycline via acid hydrolysis. It has a relative potency of 0.1 compared with oxytetracycline for inhibiting the growth of aerobic sludge bacteria, an MIC50 value of 32 mg/L for tetracycline-sensitive strains of Pseudomonas, and MIC50 values of greater than 32 mg/L for tetracycline-sensitive strains of Agrobacterium, Moraxella, and Bacillus, as well as tetracycline-resistant strains of E. coli. β-Apooxytetracycline (10 mg/kg) is toxic to rats, decreasing body weight, disrupting blood cell counts, and inducing hepatocyte necrosis.
Chemical Properties
yellow-brown to brown powder
Uses
Oxytetracycline metabolite (absolute stereochemistry unknown)
Uses
β-Apooxytetracycline is a degradation product of oxytetracycline formed under acidic conditions. An initial dehydration to anhydrooxytetracycline then undergoes an internal cyclisation of the C5-OH to the C12 ketone. The resulting cleavage of the C12-C12a bond generates two isomers, α- and β-apooxytetracycline. β-apooxytetracycline is an important standard for monitoring oxytetracycline stability.
Uses
β-Apooxytetracycline is a degradation product of oxytetracycline formed under acidic conditions. After initial dehydration to anhydrooxytetracycline, it undergoes an internal cyclisation of the C5-OH to the C12 ketone. The resulting cleavage of the C12-C12a bond generates two isomers, α- and β-apooxytetracycline. β-Apooxytetracycline is an important standard for monitoring oxytetracycline stability.
References
[1] ANNE KRUSE LYKKEBERG . Quantitative analysis of oxytetracycline and its impurities by LC-MS-MS[J]. Journal of pharmaceutical and biomedical analysis, 2004, 34 2: Pages 325-332. DOI: 10.1016/s0731-7085(03)00500-4
[2] B. HALLING-SRENSEN J. T G Sengelv. Toxicity of Tetracyclines and Tetracycline Degradation Products to Environmentally Relevant Bacteria, Including Selected Tetracycline-Resistant Bacteria[J]. Archives of Environmental Contamination and Toxicology, 2002, 42 3: 263-271. DOI: 10.1007/s00244-001-0017-2
[3] N. HUE. PRELIMINARY STUDIES ON THE TOXIC EFFECTS OF DEGRADATION PRODUCTS OF OXYTETRACYCLINE AND CHLORTETRACYCLINE ON RATS[J]. Hue University Journal of Science: Natural Science, 2015, 438 1: 467-475. DOI: 10.17265/2161-6256/2015.12.004
β-Apo-oxytetracycline Preparation Products And Raw materials
Raw materials
Preparation Products
β-Apo-oxytetracycline Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Guangzhou Longying Biotechnology Co., Ltd. | 15975567350 | loninbio@sohu.com | China | 497 | 58 |
| Guangzhou Austine Biotechnology Co., LTD | 15918640830 13268843209 | 1947181658@qq.com | China | 9146 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Sichuan Kulinan Technology Co., Ltd | 400-1166-196 18981987031 | cdhxsj@163.com | China | 11674 | 57 |
| Thermo Fisher Scientific | 800-810-5118 | cnchemical@thermofisher.com | China | 17752 | 75 |
| Clearsynth Labs Limited | +91-22-26355700 | info@clearsynth.com | India | 9656 | 58 |
| Quality Control Solutions Ltd. | 0755-66853366 13670046396 | orders@qcsrm.com | China | 18188 | 56 |
| Shandong Boluoda Biological Technology Co., Ltd. | 0531-68651502 | 2310993908@qq.com | China | 3228 | 58 |
| Shanghai Kewel Chemical Co., Ltd. | 021-64609169 18901607656 | greensnown@163.com | China | 9883 | 50 |
View Latest Price from β-Apo-oxytetracycline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-11 | β-Apooxytetracycline
18751-99-0
|
$275.00-2090.00 | 10g | TargetMol Chemicals Inc. | |||
 |
2019-12-26 | ALPHA-APO-OXYTETRACYCLINE
18751-99-0
|
$1.00 | 1g | ≥98% | Career Henan Chemical Co |
-
- β-Apooxytetracycline
18751-99-0
- $275.00-2090.00
- TargetMol Chemicals Inc.
-
- ALPHA-APO-OXYTETRACYCLINE
18751-99-0
- $1.00
- ≥98%
- Career Henan Chemical Co
