2-([1]benzofuro[3,2-d]pyrimidin-4-ylsulfanyl)-N-(3-hydroxyphenyl)acetamide
![2-([1]benzofuro[3,2-d]pyrimidin-4-ylsulfanyl)-N-(3-hydroxyphenyl)acetamide Structure](CAS/20180723/GIF/848688-62-0.gif)
- CAS No.
- 848688-62-0
- Chemical Name:
- 2-([1]benzofuro[3,2-d]pyrimidin-4-ylsulfanyl)-N-(3-hydroxyphenyl)acetamide
- Synonyms
- CAY10721;CAY10721,CAY-10721;2-(benzofuro[3,2-d]pyrimidin-4-ylthio)-N-(3-hydroxyphenyl)acetamide;Acetamide, 2-(benzofuro[3,2-d]pyrimidin-4-ylthio)-N-(3-hydroxyphenyl)-;2-([1]benzofuro[3,2-d]pyrimidin-4-ylsulfanyl)-N-(3-hydroxyphenyl)acetamide
- CBNumber:
- CB94593455
- Molecular Formula:
- C18H13N3O3S
- Molecular Weight:
- 351.37912
- MDL Number:
- MFCD04192306
- MOL File:
- 848688-62-0.mol
- MSDS File:
- SDS
| Boiling point | 651.8±55.0 °C(Predicted) |
|---|---|
| Density | 1.50±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH 7.2) (1:4): 0.20 mg/ml |
| form | A crystalline solid |
| pka | 9.43±0.10(Predicted) |
2-([1]benzofuro[3,2-d]pyrimidin-4-ylsulfanyl)-N-(3-hydroxyphenyl)acetamide price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 22403 | CAY10721 ≥98% | 848688-62-0 | 1mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 22403 | CAY10721 ≥98% | 848688-62-0 | 5mg | $153 | 2026-04-30 | Buy |
| Cayman Chemical | 22403 | CAY10721 ≥98% | 848688-62-0 | 10mg | $268 | 2026-04-30 | Buy |
| Cayman Chemical | 22403 | CAY10721 ≥98% | 848688-62-0 | 25mg | $587 | 2026-04-30 | Buy |
| Biosynth | YIB68862 | 2-([1]Benzofuro[3,2-d]pyrimidin-4-ylsulfanyl)-N-(3-hydroxyphenyl)acetamide | 848688-62-0 | 50mg | $1723 | 2026-06-05 | Buy |
2-([1]benzofuro[3,2-d]pyrimidin-4-ylsulfanyl)-N-(3-hydroxyphenyl)acetamide Chemical Properties,Uses,Production
Description
CAY10721 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (39% SIRT3 inhibition at 200 μM). Upregulation of SIRT3 transcription is associated with oral squamous cell carcinoma (OSCC) and breast cancer with lymph node involvement, while SIRT3 down-regulation inhibits the growth of OSCC cells and sensitizes them to radiation and chemotherapy.
Uses
SIRT3-IN-2 (Inhibitor scaffolds in Scheme 1) is a SIRT3 inhibitor, reducing SIRT3 activity by 39% at a concentration of 200 μM. SIRT3-IN-2 is promising for research into metabolic homeostasis and tumor suppression[1].
IC 50
SIRT3
References
[1] Salo HS, et al. Identification of novel SIRT3 inhibitor scaffolds by virtual screening. Bioorg Med Chem Lett. 2013 May 15;23(10):2990-5. DOI:10.1016/j.bmcl.2013.03.033
2-([1]benzofuro[3,2-d]pyrimidin-4-ylsulfanyl)-N-(3-hydroxyphenyl)acetamide Preparation Products And Raw materials
Raw materials
Preparation Products
2-([1]benzofuro[3,2-d]pyrimidin-4-ylsulfanyl)-N-(3-hydroxyphenyl)acetamide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9909 | 65 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
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