Methyllycaconitine (citrate)
- CAS No.
- 351344-10-0
- Chemical Name:
- Methyllycaconitine (citrate)
- Synonyms
- Methyllycaconitine citrate (1:1);(10S)-Methyllycaconitine citrate;Methyllycaconitine citrate, 10 mM in DMSO;((3S,6S,6aS,7R,7aR,8S,9R,10S,11aR,12S,12aS,13S,14R)-1-Ethyl-11a,12-dihydroxy-6,8,10,13-tetramethoxydodecahydro-2H-3,6a,12-(epiethane[1,1,2]triyl)-7,9-methanonaphtho[2,3-b]azocin-3(4H)-yl)methyl 2-((S)-3-methyl-2,5-dioxopyrrolidin-1-yl)benzoate 2-hydroxypropane-1,2,3-tricarboxylate(1:1)
- CBNumber:
- CB94666704
- Molecular Formula:
- C43H58N2O17
- Molecular Weight:
- 874.93
- MDL Number:
- MOL File:
- 351344-10-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301-H311-H331 |
| Precautionary statements | P261-P264-P270-P271-P280-P302+P352-P304+P340-P310-P330-P361-P403+P233-P405-P501 |
Methyllycaconitine (citrate) price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 21398 | Methyllycaconitine (citrate) ≥98% | 351344-10-0 | 1mg | $38 | 2026-04-30 | Buy |
| Cayman Chemical | 21398 | Methyllycaconitine (citrate) ≥98% | 351344-10-0 | 5mg | $102 | 2026-04-30 | Buy |
| Cayman Chemical | 21398 | Methyllycaconitine (citrate) ≥98% | 351344-10-0 | 10mg | $147 | 2026-04-30 | Buy |
| Cayman Chemical | 21398 | Methyllycaconitine (citrate) ≥98% | 351344-10-0 | 25mg | $317 | 2026-04-30 | Buy |
| ChemScene | CS-0021211 | Methyllycaconitine citrate 98.88% | 351344-10-0 | 5mg | $76 | 2026-06-04 | Buy |
Methyllycaconitine (citrate) Chemical Properties, Uses, Production
Description
Methyllycaconitine (MLA) is an antagonist of α7-containing neuronal nicotinic acetylcholine receptors (nAChRs; Ki = 1.4 nM). It is less effective at other nAChRs. MLA is used to selectively evaluate the role of α7-containing nAChRs in signaling pathways.
Uses
Methyllycaconitine citrate is a specific antagonist of α7 neuronal nicotinic acetylcholine receptor (α7nAChR) with blood-brain barrier permeability.
in vivo
Methyllycaconitine citrate (MLA) (6 mg/kg) given alone intraperitoneally does not cause climbing behavior when compare with the saline group. Pretreatment with Methyllycaconitine citrate significantly inhibits methamphetamine (METH)-induced climbing behavior, by about 50%. Methyllycaconitine citrate does not modify either basal locomotor activity or METH-induced hyperlocomotion. The METH-induced depletion of dopamine neuron terminals is attenuated in mice pretreated with Methyllycaconitine citrate (250±43 fmol/mg, n=7). A direct effect of Methyllycaconitine citrate on body temperature is ruled out because Methyllycaconitine citrate does not affect basal body temperature (37.0±0.5°C, n=5) or reduce the METH-induced hyperthermia (38.2±0.4°C, n=6, MLA+METH group, n.s. versus METH group)[1].
storage
Store at -20°C
References
[1] Zheng X, et al. Methyllycaconitine alleviates amyloid-β peptides-induced cytotoxicity in SH-SY5Y cells. PLoS One. 2014 Oct 31;9(10):e111536. DOI:10.1371/journal.pone.0111536
[2] Escubedo E, et al. Methyllycaconitine prevents methamphetamine-induced effects in mouse striatum: involvement of alpha7 nicotinic receptors. J Pharmacol Exp Ther. 2005 Nov;315(2):658-67. DOI:10.1124/jpet.105.089748
[3] Lockman PR, et al. Chronic nicotine exposure alters blood-brain barrier permeability and diminishes brain uptake of methyllycaconitine. J Neurochem. 2005 Jul;94(1):37-44. DOI:10.1111/j.1471-4159.2005.03162.x
Methyllycaconitine (citrate) Preparation Products And Raw materials
Raw materials
Preparation Products
Methyllycaconitine (citrate) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Macklin Biochemical Co.,Ltd. | 15221275939 15221275939 | shenlinxing@macklin.cn | China | 15775 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Dezhou LonWel Pharmaceutical Technology Co., Ltd. | 13761310616 | 39324283@qq.com | China | 1365 | 58 |
| Shanghai Jizhi Biochemical Technology Co. Ltd. | 021-4009004166/18616739031 18616739031 | 3007523370@qq.com | China | 40000 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Shanghai hongqu biomedical technology co. LTD | 88888888888 | hongquchem@qq.com | China | 5123 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 |
| Shanghai Taopu Industrial Co., LTD | 15900573766 18018507602 | 3165608826@qq.com | China | 4406 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
View Latest Price from Methyllycaconitine (citrate) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-21 | Methyllycaconitine citrate
351344-10-0
|
$199.00 | 99.43% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-07-21 | Methyllycaconitine citrate
351344-10-0
|
$199.00 | 99.43% | 10g | TargetMol Chemicals Inc. |
-
- Methyllycaconitine citrate
351344-10-0
- $199.00
- 99.43%
- TargetMol Chemicals Inc.
-
- Methyllycaconitine citrate
351344-10-0
- $199.00
- 99.43%
- TargetMol Chemicals Inc.
