PF-DcpSi

PF-DcpSi structure

CAS No.: 2092917-19-4

Chemical Name:: PF-DcpSi

Synonyms: PF-DcpSi;Benzonitrile, 3-[(2,4-diamino-5-quinazolinyl)methoxy]-5-fluoro-

CBNumber:: CB94668384

Molecular Formula:: C16H12FN5O

Molecular Weight:: 309.3

MDL Number:

MOL File:: 2092917-19-4.mol

MSDS File:: SDS

Last updated:2025-04-18 09:53:08

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PF-DcpSi Properties

Boiling point	598.1±60.0 °C(Predicted)
Density	1.45±0.1 g/cm3(Predicted)
pka	7.84±0.10(Predicted)

PF-DcpSi price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0087430	PF-DcpSi 98.0%	2092917-19-4	5mg	$520	2026-06-04	Buy
ChemScene	CS-0087430	PF-DcpSi 98.0%	2092917-19-4	10mg	$780	2026-06-04	Buy
aablocks	AA01V1OA	3-((2,4-Diaminoquinazolin-5-yl)methoxy)-5-fluorobenzonitrile >98%	2092917-19-4	5mg	$569	2026-05-31	Buy
aablocks	AA01V1OA	3-((2,4-Diaminoquinazolin-5-yl)methoxy)-5-fluorobenzonitrile >98%	2092917-19-4	10mg	$835	2026-05-31	Buy

Product number	Packaging	Price	Buy
CS-0087430	5mg	$520	Buy
CS-0087430	10mg	$780	Buy
AA01V1OA	5mg	$569	Buy
AA01V1OA	10mg	$835	Buy

PF-DcpSi Chemical Properties, Uses, Production

Uses

PF-DcpSi is a mRNA decapping scavenger enzyme (DcpS) inhibitor (IC50: 0.11 nM). PF-DcpSi (30 mg/kg,i.p.) ameliorates the disease phenotype in a mice model of spinal muscular atrophy (SMA)[1].

References

[1] Gopalsamy A, et al. Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA). J Med Chem. 2017 Apr 13;60(7):3094-3108. DOI:10.1021/acs.jmedchem.7b00124

PF-DcpSi Preparation Products And Raw materials

Raw materials

Preparation Products

PF-DcpSi Suppliers

Global Suppliers ( 2)

Supplier	Tel	Email	Country	ProdList	Advantage
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd	15317229551	15151849396@163.com	China	959	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29874	58

Supplier	Advantage
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd	58
TargetMol Chemicals Inc.	58

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PF-DcpSi Benzonitrile, 3-[(2,4-diamino-5-quinazolinyl)methoxy]-5-fluoro- 2092917-19-4