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ChemicalBook >> CAS DataBase List >>7-Benzyloxy-4-chloro-6-methoxyquinazoline

7-Benzyloxy-4-chloro-6-methoxyquinazoline

7-Benzyloxy-4-chloro-6-methoxyquinazoline Structure
7-Benzyloxy-4-chloro-6-methoxyquinazoline structure
CAS No.
162364-72-9
Chemical Name:
7-Benzyloxy-4-chloro-6-methoxyquinazoline
Synonyms
7-Benzyloxy-4-chloro-6-methoxyquinazoli;162364-72-9;7-Benzyloxy-4-chloro-6-methoxy-quizoline;4-Chloro-6-methoxy-7-benzyloxyquinazoline;7-BENZYLOXY-4-CHLORO-6-METHOXY-QUINAZOLINE;4-chloro-7-benzyloxy -6-Methoxyquinazoline;7-(Benzyloxy)-4-chloro-6-methoxyquinazoline 98%;4-chloro-6-methoxy-7-(phenylmethoxy)quinazoline;Quinazoline, 4-chloro-6-Methoxy-7-(phenylMethoxy)-;Quinazoline,4-chloro-6-methoxy-7-(phenylmethoxy)-,98%
CBNumber:
CB9474149
Molecular Formula:
C16H13ClN2O2
Molecular Weight:
300.74
MDL Number:
MFCD04115120
MOL File:
162364-72-9.mol
MSDS File:
SDS
Last updated:2026-05-28 05:24:20
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7-Benzyloxy-4-chloro-6-methoxyquinazoline Properties

Boiling point 452.1±40.0 °C(Predicted)
Density 1.303±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka 0.72±0.30(Predicted)
Appearance Off-white to yellow Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P261-P280-P305+P351+P338
HS Code  2933599590

7-Benzyloxy-4-chloro-6-methoxyquinazoline price More Price(41)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific OR17604 7-(Benzyloxy)-4-chloro-6-methoxyquinazoline 98% 162364-72-9 1g $21 2026-06-04 Buy
Apolloscientific OR17604 7-(Benzyloxy)-4-chloro-6-methoxyquinazoline 98% 162364-72-9 5g $25 2026-06-04 Buy
Apolloscientific OR17604 7-(Benzyloxy)-4-chloro-6-methoxyquinazoline 98% 162364-72-9 25g $89 2026-06-04 Buy
Apolloscientific OR17604 7-(Benzyloxy)-4-chloro-6-methoxyquinazoline 98% 162364-72-9 100g $347 2026-06-04 Buy
Apolloscientific OR17604 7-(Benzyloxy)-4-chloro-6-methoxyquinazoline 98% 162364-72-9 500g $1728 2026-06-04 Buy
Product number Packaging Price Buy
OR17604 1g $21 Buy
OR17604 5g $25 Buy
OR17604 25g $89 Buy
OR17604 100g $347 Buy
OR17604 500g $1728 Buy

7-Benzyloxy-4-chloro-6-methoxyquinazoline Chemical Properties,Uses,Production

Synthesis

6-Methoxy-7-benzyloxyquinazolin-4-one

179688-01-8

7-Benzyloxy-4-chloro-6-methoxyquinazoline

162364-72-9

General procedure for the synthesis of 7-benzyloxy-4-chloro-6-methoxyquinazoline from 6-methoxy-7-(benzyloxy)quinazolin-4(3H)-one: 2.1 g of 6-methoxy-7-(benzyloxy)quinazolin-4(3H)-one (Compound IV), 9.1 g of phosphorus trichloride, and 60 mL of ethylene dichloride were mixed, and the reaction was carried out by refluxing the reaction for 1 hour at 85 °C. Upon completion of the reaction, the excess phosphorous trichloride was removed by rotary evaporation. Ice water was added to the residue and the mixture was extracted with dichloromethane. The organic phases were combined, washed with saturated sodium chloride solution and dried over anhydrous magnesium sulfate. The desiccant was removed by filtration and the filtrate was concentrated under reduced pressure and purified by silica gel column chromatography, using a gradient elution of n-hexane to ethyl acetate in 5:1, 3:1 and 1:1 volume ratios, respectively. The eluted fractions at a volume ratio of hexane to ethyl acetate of 1:1 were collected to give 2.1 g of off-white solid (7-benzyloxy-4-chloro-6-methoxyquinazoline, compound 5) in 93.9% yield.

References

[1] Patent: CN105541736, 2016, A. Location in patent: Paragraph 0044; 0049
[2] European Journal of Medicinal Chemistry, 2017, vol. 125, p. 245 - 254
[3] Patent: CN105884699, 2016, A. Location in patent: Paragraph 0062; 0063
[4] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 18, p. 5342 - 5346

7-Benzyloxy-4-chloro-6-methoxyquinazoline Preparation Products And Raw materials

Raw materials

6-Methoxy-7-benzyloxyquinazolin-4-one 1,2-Dichloroethane trichlorophosphate

Preparation Products

7-(benzyloxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine

7-Benzyloxy-4-chloro-6-methoxyquinazoline Suppliers

Global( 152)Suppliers
Supplier Tel Email Country ProdList Advantage
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
Carbott PharmTech Inc. 0535-6385396 info@carbottpharm.com China 996 56
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16305 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Jinan Trio PharmaTech Co., Ltd. 0531-88811783 sales@trio-pharmatech.com China 1856 62
Shanghai Ennopharm Co., Ltd. +86 (21) 6435-5022 China 4263 65
Shanghai Topbiochem Technology Co., Ltd 021-58170097 info@topbiochem.com China 9513 58
Supplier Advantage
Chembest Research Laboratories Limited 61
Carbott PharmTech Inc. 56
JinYan Chemicals(ShangHai) Co.,Ltd. 60
Pure Chemistry Scientific Inc. 62
Adamas Reagent, Ltd. 59
Nanjing Chemlin Chemical Co., Ltd 64
Shanghai Hanhong Scientific Co.,Ltd. 64
Jinan Trio PharmaTech Co., Ltd. 62
Shanghai Ennopharm Co., Ltd. 65
Shanghai Topbiochem Technology Co., Ltd 58

View Lastest Price from 7-Benzyloxy-4-chloro-6-methoxyquinazoline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
7-Benzyloxy-4-chloro-6-methoxyquinazoline pictures 2026-08-20 7-Benzyloxy-4-chloro-6-methoxyquinazoline
162364-72-9
 $1.10 1g 99.0% Min 100 Tons Dideu Industries Group Limited
7-Benzyloxy-4-chloro-6-methoxyquinazoline pictures 2019-12-24 7-Benzyloxy-4-chloro-6-methoxyquinazoline
162364-72-9
 $1.00 1KG 99% Career Henan Chemical Co

7-Benzyloxy-4-chloro-6-methoxyquinazoline Spectrum

7-Benzyloxy-4-chloro-6-methoxyquinazoline(162364-72-9)1HNMR

162364-72-9(7-Benzyloxy-4-chloro-6-methoxyquinazoline)Related Search:

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Methoxy 6-Hydroxyl-7-Ethoxyquinazoline-4-One

1of4

4-Chloro-6-methoxy-7-benzyloxyquinazoline 7-BENZYLOXY-4-CHLORO-6-METHOXY-QUINAZOLINE Quinazoline, 4-chloro-6-Methoxy-7-(phenylMethoxy)- 4-chloro-7-benzyloxy -6-Methoxyquinazoline 4-chloro-6-methoxy-7-(phenylmethoxy)quinazoline 7-(Benzyloxy)-4-chloro-6-methoxyquinazoline 98% 7-Benzyloxy-4-chloro-6-methoxy-quizoline Quinazoline,4-chloro-6-methoxy-7-(phenylmethoxy)-,98% 7-Benzyloxy-4-chloro-6-methoxyquinazoline ISO 9001：2015 REACH 7-Benzyloxy-4-chloro-6-methoxyquinazoli 162364-72-9 162364-72-9