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ChemicalBook >> CAS DataBase List >>4,5-Dimethyl-1,3-thiazol-2-amine

4,5-Dimethyl-1,3-thiazol-2-amine

4,5-Dimethyl-1,3-thiazol-2-amine Structure
4,5-Dimethyl-1,3-thiazol-2-amine structure
CAS No.
2289-75-0
Chemical Name:
4,5-Dimethyl-1,3-thiazol-2-amine
Synonyms
AURORA 5329;ASISCHEM D48929;AKOS BBS-00004664;IFLAB-BB F1920-0013;white to light yellow solid;4,5-DIMETHYLTHIAZOL-2-AMINE;DIMETHYL-1,3-THIAZOL-2-AMINE;2-ThiazolaMine,4,5-diMethyl-;4,5-DIMETHYL-THIAZOL-2-YLAMINE;4,5-dimethyl-1,3-thiazol-2-amin
CBNumber:
CB9494620
Molecular Formula:
C5H8N2S
Molecular Weight:
128.2
MDL Number:
MFCD00462425
MOL File:
2289-75-0.mol
MSDS File:
SDS
Last updated:2026-09-12 18:56:30
Request For Quotation

4,5-Dimethyl-1,3-thiazol-2-amine Properties

Melting point 66-69
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
form crystalline solid
color Very dark red/ brown
CAS DataBase Reference 2289-75-0(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xi,Xn
Risk Statements  22
HazardClass  IRRITANT
HS Code  2934100090

4,5-Dimethyl-1,3-thiazol-2-amine price More Price(61)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical A2916 4,5-Dimethylthiazol-2-amine 2289-75-0 1G $45 2026-04-30 Buy
TCI Chemical A2916 4,5-Dimethylthiazol-2-amine 2289-75-0 5G $135 2026-04-30 Buy
Activate Scientific AS28555 2-Amino-4,5-dimethylthiazole 95% 2289-75-0 1g $20 2026-06-04 Buy
Apolloscientific OR14117 2-Amino-4,5-dimethyl-1,3-thiazole 95% 2289-75-0 250mg $21 2026-06-04 Buy
Apolloscientific OR14117 2-Amino-4,5-dimethyl-1,3-thiazole 95% 2289-75-0 1g $24 2026-06-04 Buy
Product number Packaging Price Buy
A2916 1G $45 Buy
A2916 5G $135 Buy
AS28555 1g $20 Buy
OR14117 250mg $21 Buy
OR14117 1g $24 Buy

4,5-Dimethyl-1,3-thiazol-2-amine Chemical Properties, Uses, Production

Synthesis

3-Chloro-2-butanone

4091-39-8

Carbamimidothioic acid

17356-08-0

4,5-DIMETHYL-1,3-THIAZOL-2-AMINE

2289-75-0

1. In a 250 mL three-necked round-bottomed flask equipped with a stirrer, condenser tube, and constant-pressure dropping funnel, 43.27 g (0.6 mol) of 3-chloro-2-butanone and 30.42 g (0.3 mol) of 36% hydrochloric acid were added. Subsequently, 8.1 g (0.06 mol) of copper chloride was added and the reaction system was warmed to 35°C. 49.23 g (0.39 mol) of 30% hydrogen peroxide was added slowly and dropwise over a period of 15 minutes. After the dropwise addition was completed, the reaction mixture was heated to 78°C and refluxed for 5 hours. After completion of the reaction, it was cooled to room temperature, the organic phase was separated, washed twice sequentially with saturated sodium carbonate solution and dried over anhydrous sodium sulfate. The 137-140°C fraction was collected by decompression distillation to give 8.0 g of 3-chloro-2-butanone derivative XVII in 12.6% yield. 2. 30 mL of ethanol and 3.5 g (47 mmol) of thiourea were added to a 100 mL round-bottomed flask and heated to reflux with stirring until the thiourea was completely dissolved. Subsequently, 5.0 g (47 mmol) of 3-chloro-2-butanone derivative XVII was added and refluxing was continued overnight. After completion of the reaction, the ethanol was removed by concentration under reduced pressure. The crude product obtained was dissolved in 30 mL of dichloromethane, washed with saturated sodium carbonate solution, the organic layer was separated and dried over anhydrous sodium sulfate. After concentration, a yellow oil was obtained, which was further processed to give 2-amino-4,5-dimethylthiazole XVIII 3.8 g in 63.3% yield.

References

[1] Patent: CN102942565, 2016, B. Location in patent: Paragraph 0040-0043; 0093-0094
[2] Chemistry of Heterocyclic Compounds (New York, NY, United States), 1965, vol. 1, p. 200 - 201
[3] Khimiya Geterotsiklicheskikh Soedinenii, 1965, vol. 1, p. 303 - 305
[4] Russian Journal of Organic Chemistry, 2013, vol. 49, # 4, p. 575 - 579
[5] Zh. Org. Khim., 2013, vol. 49, # 4, p. 591 - 595,5

4,5-Dimethyl-1,3-thiazol-2-amine Preparation Products And Raw materials

Raw materials

3-Chloro-2-butanone Carbamimidothioic acid

Preparation Products

4,5-Dimethyl-1,3-thiazol-2-amine Suppliers

Global Suppliers ( 115)
Supplier Tel Email Country ProdList Advantage
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16306 64
Syntechem Co.,Ltd info@syntechem.com China 12973 57
Tianjin heowns Biochemical Technology Co., Ltd. 400 638 7771 sales@heowns.com China 14412 57
Hunan Hui Bai Shi Biotechnology Co., Ltd. 0731-85526065 13308475853 ivy@hnhbsj.com China 7236 62
Shanghai Sphchem Co., Ltd. 021-56491756 13512199871 2819742715@qq.com China 3994 55
Shanghai Topbiochem Technology Co., Ltd 021-58170097 info@topbiochem.com China 9509 58
Shanghai Witofly Chemical Co.,Ltd sales@witofly.com China 2853 52
Supplier Advantage
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Wuhan Chemwish Technology Co., Ltd 56
Beijing Ouhe Technology Co., Ltd 60
Nanjing Chemlin Chemical Co., Ltd 64
Syntechem Co.,Ltd 57
Tianjin heowns Biochemical Technology Co., Ltd. 57
Hunan Hui Bai Shi Biotechnology Co., Ltd. 62
Shanghai Sphchem Co., Ltd. 55
Shanghai Topbiochem Technology Co., Ltd 58
Shanghai Witofly Chemical Co.,Ltd 52

View Latest Price from 4,5-Dimethyl-1,3-thiazol-2-amine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4,5-DIMETHYL-1,3-THIAZOL-2-AMINE pictures 2019-08-08 4,5-DIMETHYL-1,3-THIAZOL-2-AMINE
2289-75-0
 $1.00 1KG 98% 100KG Career Henan Chemical Co

4,5-Dimethyl-1,3-thiazol-2-amine Spectrum

4,5-DIMETHYL-1,3-THIAZOL-2-AMINE(2289-75-0)1HNMR4,5-DIMETHYL-1,3-THIAZOL-2-AMINE(2289-75-0)FT-IR

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2-Amino-4,5-dimethyl-1,3-thiazole 95% DIMETHYL-1,3-THIAZOL-2-AMINE IFLAB-BB F1920-0013 AURORA 5329 ASISCHEM D48929 AKOS BBS-00004664 4,5-DIMETHYL-THIAZOL-2-YLAMINE 2-Amino-4,5-dimethyl-1,3-thiazole 4,5-DIMETHYLTHIAZOL-2-AMINE 4,5-dimethyl-1,3-thiazol-2-amine(SALTDATA: HCl) white to light yellow solid 2-ThiazolaMine,4,5-diMethyl- 4,5-Dimethyl-2-Thiazolamine 4,5-Dimethyl-1,3-Thiazol-2-Amine(SALTDATA: Hcl) 4,5-dimethyl-1,3-thiazol-2-amin 4,5-Dimethyl-1,3-thiazol-2-amine 2289-75-0 pharmaceutical intermediate amine