5-Cyclopropylisoxazole-3-carboxylic aci&
- CAS No.
- 110256-15-0
- Chemical Name:
- 5-Cyclopropylisoxazole-3-carboxylic aci&
- Synonyms
- 5-Cyclopropylisoxazole-3-carboxylic aci&;5-cyclopropyl-3-isoxazolecarboxylic acid;3-Isoxazolecarboxylicacid, 5-cyclopropyl-;3-Isoxazolecarboxylicacid,5-cyclopropyl-(9CI);5-cyclopropylisoxazole-3-carboxylic acid(SALTDATA: FREE)
- CBNumber:
- CB9498835
- Molecular Formula:
- C7H7NO3
- Molecular Weight:
- 153.14
- MDL Number:
- MFCD05668325
- MOL File:
- 110256-15-0.mol
- MSDS File:
- SDS
| Melting point | 96-100 °C(lit.) |
|---|---|
| Boiling point | 358.1±30.0 °C(Predicted) |
| Density | 1.445 |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| form | solid |
| pka | 3.46±0.10(Predicted) |
| Appearance | Off-white to light brown Solid |
| InChI | 1S/C7H7NO3/c9-7(10)5-3-6(11-8-5)4-1-2-4/h3-4H,1-2H2,(H,9,10) |
| InChIKey | OWMVXHFZCCPOTD-UHFFFAOYSA-N |
| SMILES | OC(=O)c1cc(on1)C2CC2 |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| WGK Germany | 3 |
| HS Code | 2934999090 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral |
5-Cyclopropylisoxazole-3-carboxylic aci& price More Price(58)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 644803 | 5-Cyclopropylisoxazole-3-carboxylic acid 95% | 110256-15-0 | 1g | $96.7 | 2026-04-30 | Buy |
| Sigma-Aldrich | 644803 | 5-Cyclopropylisoxazole-3-carboxylic acid 95% | 110256-15-0 | 5g | $425 | 2026-04-30 | Buy |
| Usbiological | 270498 | 5-Cyclopropylisoxazole-3-carboxylic acid Asreported | 110256-15-0 | 250mg | $347 | 2026-06-03 | Buy |
| Usbiological | 270498 | 5-Cyclopropylisoxazole-3-carboxylic acid Asreported | 110256-15-0 | 500mg | $460 | 2026-06-03 | Buy |
| Usbiological | 270498 | 5-Cyclopropylisoxazole-3-carboxylic acid Asreported | 110256-15-0 | 1g | $588 | 2026-06-03 | Buy |
5-Cyclopropylisoxazole-3-carboxylic aci& Chemical Properties, Uses, Production
Uses
5-Cyclopropylisoxazole-3-carboxylic Acid is a compound that has been used in the discovery, design and synthesis of a selective S1P3 receptor allosteric agonist (N,N-Dicyclohexyl-5-propylisoxazole-3-carboxamide).
Synthesis
21080-81-9
110256-15-0
The general procedure for the synthesis of 5-cyclopropylisoxazole-3-carboxylic acid from ethyl 5-cyclopropylisoxazole-3-carboxylate was as follows:Intermediate 16 - Preparation of 5-cyclopropylisoxazole-3-carboxylic acid. A mixture of ethyl 5-cyclopropylisoxazole-3-carboxylate (0.550 g, 3.04 mmol) with 1M aqueous sodium hydroxide (9.11 mL, 9.11 mmol) was stirred at room temperature for 72 hours. Upon completion of the reaction, the pH of the reaction solution was adjusted to 1 with 6N hydrochloric acid, followed by extraction with ethyl acetate. The organic layer was separated, dried with anhydrous magnesium sulfate and concentrated under reduced pressure to give 0.446 g of 5-cyclopropylisoxazole-3-carboxylic acid as a solid in 96% yield. The product was confirmed by mass spectrometry: ESI/APCI(+) m/z: 154 (M+H), 176 (M+Na); ESI/APCI(-) m/z: 152 (M-H).
References
[1] Journal of Medicinal Chemistry, 2016, vol. 59, # 1, p. 358 - 373
[2] Patent: WO2010/142801, 2010, A1. Location in patent: Page/Page column 151
[3] Patent: US2003/236287, 2003, A1. Location in patent: Page 46, 47
[4] Patent: WO2016/40502, 2016, A1. Location in patent: Page/Page column 65
[5] Patent: WO2016/40504, 2016, A1. Location in patent: Paragraph 0194
5-Cyclopropylisoxazole-3-carboxylic aci& Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shanghai Ennopharm Co., Ltd. | +86 (21) 6435-5022 | China | 4263 | 65 | |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| Wuhan TCASChem Technology Co., Ltd. | 027-86697669 13986148687 | sales@tcaschem.com | China | 4000 | 55 |
| Nanjing Norris-Pharm Technology Co., Ltd | 13901585132 | sales@norris-pharm.com | China | 8869 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14982 | 55 |
| Shanghai XR Chemical Technology Co., Ltd. | 021-31007982 18019432809; | info@xrpharma.com | China | 686 | 55 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
View Latest Price from 5-Cyclopropylisoxazole-3-carboxylic aci& manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-03 | 5-CYCLOPROPYLISOXAZOLE-3-CARBOXYLIC ACI
110256-15-0
|
$6.60 | 1KG | 97%-99% | 1kg -1000kg | Career Henan Chemical Co |
-
- 5-CYCLOPROPYLISOXAZOLE-3-CARBOXYLIC ACI
110256-15-0
- $6.60
- 97%-99%
- Career Henan Chemical Co
