CHK2 INHIBITOR II
- CAS No.
- 516480-79-8
- Chemical Name:
- CHK2 INHIBITOR II
- Synonyms
- C 3742;BML-277;CS-1761;BML-277, >98%;Chk2InhibitorⅡ;BML-277 (C 3742);C 3742 BML-277;BML-277, 10 mM in DMSO;BML-277,CHK2 INHIBITOR II;Chk2 Inhibitor II hydrate
- CBNumber:
- CB9503256
- Molecular Formula:
- C20H14ClN3O2
- Molecular Weight:
- 363.8
- MDL Number:
- MFCD08276917
- MOL File:
- 516480-79-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Chk2 Inhibitor II | 220486 | 1mg | $190 |
| InSolution? Chk2 Inhibitor II | 220491 | 5mg | $280 |
| Chk2 Inhibitor II ≥98% | 17552 | 1mg | $36 |
| Chk2 Inhibitor II ≥98% | 17552 | 5mg | $103 |
| Chk2 Inhibitor II ≥98% | 17552 | 10mg | $132 |
| More product size | |||
| Boiling point | 637.1±63.0 °C(Predicted) |
|---|---|
| Density | 1.390±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: 18 mg/mL |
| form | solid |
| pka | 10.40±0.10(Predicted) |
| color | tan |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| InChI | 1S/C20H14ClN3O2/c21-14-4-8-16(9-5-14)26-15-6-1-12(2-7-15)20-23-17-10-3-13(19(22)25)11-18(17)24-20/h1-11H,(H2,22,25)(H,23,24) |
| InChIKey | UXGJAOIJSROTTN-UHFFFAOYSA-N |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| WGK Germany | 3 |
| Storage Class | 10 - Combustible liquids |
CHK2 INHIBITOR II price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 220486 | Chk2 Inhibitor II | 516480-79-8 | 1mg | $190 | 2026-04-30 | Buy |
| Sigma-Aldrich | 220491 | InSolution? Chk2 Inhibitor II | 516480-79-8 | 5mg | $280 | 2023-01-07 | Buy |
| Cayman Chemical | 17552 | Chk2 Inhibitor II ≥98% | 516480-79-8 | 1mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 17552 | Chk2 Inhibitor II ≥98% | 516480-79-8 | 5mg | $103 | 2026-04-30 | Buy |
| Cayman Chemical | 17552 | Chk2 Inhibitor II ≥98% | 516480-79-8 | 10mg | $132 | 2026-04-30 | Buy |
CHK2 INHIBITOR II Chemical Properties,Uses,Production
Description
Chk2 inhibitor II is a selective, ATP-competitive inhibitor of the DNA damage control kinase, checkpoint kinase 2 (IC50 = 15 nM). It has been shown to prevent apoptosis in human T-cells exposed to ionizing radiation (EC50 = 3-7.6 μM). This compound has been used to target the role of Chk2 in cellular signaling in response to DNA damage.
Uses
Chk2 Inhibitor II is a selective APT-competitive inhibitors of the DNA damage response signaling enzyme checkpoint kinase 2 (CHK2).
Biochem/physiol Actions
Chk2 Inhibitor II is a checkpoint kinase 2 inhibitor, which controls the p53 response to DNA breaks induced by radiation, leading to apoptosis. Protection of T-cells from apoptosis implies use as an adjuvant for radiation therapy in cancer. IC50 = 15 nM; Ki = 37 nM. Chk2 Inhibitor II shows 1000-fold greater selectivity for the Chk2 serine/threonine kinase than for the Cdk1/B and CK1 kinases (for which IC50 = 12 μM and 17 μM, respectively). Chk2 Inhibitor II weakly inhibits a panel of 31 other kinases (<25% inhibition at a concentration of 10 μM and prevents apoptosis of human CD4+ and CD8+ T-cells subjected to ionizing radiation (EC50 = 3 μM and 7.6 μM, respectively).
References
[1] KRISTEN L. ARIENTI. Checkpoint Kinase Inhibitors: SAR and Radioprotective Properties of a Series of 2-Arylbenzimidazoles[J]. Journal of Medicinal Chemistry, 2004, 48 6: 1873-1885. DOI:10.1021/jm0495935
[2] YARON PEREG. Differential roles of ATM- and Chk2-mediated phosphorylations of Hdmx in response to DNA damage.[J]. Molecular and Cellular Biology, 2006, 26 18: 6819-6831. DOI:10.1128/mcb.00562-06
CHK2 INHIBITOR II Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29766 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10378 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +86-15965530500 | nickzhang@hangyubiotech.com | China | 9935 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 +86-15355479329 | market18@leapchem.com | China | 43303 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 54746 | 58 | |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53799 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| EnliPharma Technology Co., Ltd | 0551-66399836 18955197623 | sales@enlipharma.com | China | 1875 | 55 |
View Lastest Price from CHK2 INHIBITOR II manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | BML-277
516480-79-8
|
$47.00-159.00 | 99.65% | 10g | TargetMol Chemicals Inc. | ||
 |
2019-09-06 | CHK2 INHIBITOR II
516480-79-8
|
$1.00 | 1KG | 95%~99% | Career Henan Chemical Co |
-
- BML-277
516480-79-8
- $47.00-159.00
- 99.65%
- TargetMol Chemicals Inc.
-
- CHK2 INHIBITOR II
516480-79-8
- $1.00
- 95%~99%
- Career Henan Chemical Co
