SIS17
- CAS No.
- 2374313-54-7
- Chemical Name:
- SIS17
- Synonyms
- SIS17;SIS17 - Bio-X ?;N'-Hexadecylthiophene-2-carbohydrazide;2-Thiophenecarboxylic acid, 2-hexadecylhydrazide;Histone deacetylases,SIS17,SIS-17,inhibit,HDAC,Inhibitor,SIS 17
- CBNumber:
- CB95476779
- Molecular Formula:
- C21H38N2OS
- Molecular Weight:
- 366.6
- MDL Number:
- MOL File:
- 2374313-54-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 454.9±27.0 °C(Predicted) |
|---|---|
| Density | 0.975±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| solubility |
DMSO:99.0(Max Conc. mg/mL);270.04(Max Conc. mM) Ethanol:18.0(Max Conc. mg/mL);49.1(Max Conc. mM) |
| pka | 12.38±0.23(Predicted) |
| form | Solid |
| color | White to off-white |
| InChI | 1S/C21H38N2OS/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18-22-23-21(24)20-17-16-19-25-20/h16-17,19,22H,2-15,18H2,1H3,(H,23,24) |
| InChIKey | HSHXDCVZWHOWCS-UHFFFAOYSA-N |
| SMILES | [s]1c(ccc1)C(=O)NNCCCCCCCCCCCCCCCC |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
SIS17 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 41360 | SIS17 ≥98% | 2374313-54-7 | 5mg | $39 | 2026-04-30 | Buy |
| Cayman Chemical | 41360 | SIS17 ≥98% | 2374313-54-7 | 10mg | $74 | 2026-04-30 | Buy |
| Cayman Chemical | 41360 | SIS17 ≥98% | 2374313-54-7 | 25mg | $174 | 2026-04-30 | Buy |
| Cayman Chemical | 41360 | SIS17 ≥98% | 2374313-54-7 | 50mg | $308 | 2026-04-30 | Buy |
| Biosynth | ZUD31354 | SIS17 | 2374313-54-7 | 25mg | $192.75 | 2026-06-05 | Buy |
SIS17 Chemical Properties, Uses, Production
Uses
SIS17 is a mammalian histone deacetylase 11 (HDAC 11) inhibitor with an IC50 value of 0.83 μM. SIS17 inhibits the demyristoylation of serine hydroxymethyltransferase 2, a substrate of HDAC 11, but does not inhibit other HDACs[1].
Biological Activity
SIS17 is a potent and selective HDAC11 inhibitor (IC50 = 830 nM; IC50 >100 μM against HDAC1/4/8 or SIRT1/2/3/6) th at effectively upregulates HDAC11 substrate, serine hydroxymethyl transferase 2 (SHMT2), fatty acylation level in MCF7 cells (12.5 μM).
IC 50
HDAC11: 0.83 μM (IC50)
References
[1] Son SI, et al. Activity-Guided Design of HDAC11-Specific Inhibitors. ACS Chem Biol. 2019 Jul 19;14(7):1393-1397. DOI:10.1021/acschembio.9b00292
[2] Li R, et al. A pan-cancer analysis identifies HDAC11 as an immunological and prognostic biomarker. FASEB J. 2022 Jul;36(7):e22326. DOI:10.1096/fj.202101742RR
SIS17 Preparation Products And Raw materials
Raw materials
Preparation Products
SIS17 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Beckham Medical Technology Co., Ltd | 13816613772 | huahero21@sina.com | China | 2994 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9778 | 55 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9729 | 58 |
| Heze Development Zone chuangli Chemical Co., Ltd. | 0530-+86-530-529 6766，+86-15666160102 15666160102 | info@chuangli-chem.com | China | 849 | 55 |
| Shanghai Jizhi Biochemical Technology Co. Ltd. | 021-4009004166/18616739031 18616739031 | 3007523370@qq.com | China | 40000 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9718 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6378 | 58 |
| Chengdu Peter-like Biotechnology Co., Ltd. | 18108052721 | 2850505130@qq.com | China | 5037 | 58 |
