SIS17 manufacturers
- SIS17
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- $59.00 / 5mg
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2025-10-14
- CAS:2374313-54-7
- Min. Order:
- Purity: 98.00%
- Supply Ability: 10g
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| Product Name: | SIS17 | | Synonyms: | SIS17;2-Thiophenecarboxylic acid, 2-hexadecylhydrazide;N'-Hexadecylthiophene-2-carbohydrazide;Histone deacetylases,SIS17,SIS-17,inhibit,HDAC,Inhibitor,SIS 17;SIS17 - Bio-X ? | | CAS: | 2374313-54-7 | | MF: | C21H38N2OS | | MW: | 366.6 | | EINECS: | | | Product Categories: | | | Mol File: | 2374313-54-7.mol |  |
| | SIS17 Chemical Properties |
| Boiling point | 454.9±27.0 °C(Predicted) | | density | 0.975±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C(protect from light) | | solubility | DMSO:99.0(Max Conc. mg/mL);270.04(Max Conc. mM)
Ethanol:18.0(Max Conc. mg/mL);49.1(Max Conc. mM) | | pka | 12.38±0.23(Predicted) | | form | Solid | | color | White to off-white |
| | SIS17 Usage And Synthesis |
| Uses | SIS17 is a mammalian histone deacetylase 11 (HDAC 11) inhibitor with an IC50 value of 0.83 μM. SIS17 inhibits the demyristoylation of serine hydroxymethyltransferase 2, a substrate of HDAC 11, but does not inhibit other HDACs[1]. | | Biological Activity | SIS17 is a potent and selective HDAC11 inhibitor (IC50 = 830 nM; IC50 >100 μM against HDAC1/4/8 or SIRT1/2/3/6) th at effectively upregulates HDAC11 substrate, serine hydroxymethyl transferase 2 (SHMT2), fatty acylation level in MCF7 cells (12.5 μM). | | IC 50 | HDAC11: 0.83 μM (IC50) | | References | [1] Son SI, et al. Activity-Guided Design of HDAC11-Specific Inhibitors. ACS Chem Biol. 2019 Jul 19;14(7):1393-1397. DOI:10.1021/acschembio.9b00292
[2] Li R, et al. A pan-cancer analysis identifies HDAC11 as an immunological and prognostic biomarker. FASEB J. 2022 Jul;36(7):e22326. DOI:10.1096/fj.202101742RR |
| | SIS17 Preparation Products And Raw materials |
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