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DS18561882

DS18561882 Structure
DS18561882 structure
CAS No.
2227149-22-4
Chemical Name:
DS18561882
Synonyms
DS18561882;DS18561882,DS-18561882;(S)-N-(4-(8-(3,4-Dimethylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-(trifluoromethoxy)phenyl)methanesulfonamide;Methanesulfonamide, N-[4-[[8-[(3S)-3,4-dimethyl-1-piperazinyl]-1,5-dihydro-7-methyl-5-oxo-2H-[1]benzopyrano[3,4-c]pyridin-3(4H)-yl]carbonyl]-2-(trifluoromethoxy)phenyl]-
CBNumber:
CB95848750
Molecular Formula:
C28H31F3N4O6S
Molecular Weight:
608.63
MDL Number:
MFCD32263053
MOL File:
2227149-22-4.mol
Last updated:2025-10-13 16:10:46
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DS18561882 Properties

Boiling point 754.3±70.0 °C(Predicted)
Density 1.47±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: 250 mg/mL (410.76 mM)
form Solid
pka 6.61±0.10(Predicted)
color White to yellow

DS18561882 Chemical Properties,Uses,Production

Description

DS18561882 is an isozyme-selective MTHFD2 inhibitor. DS18561882 shows a good oral pharmacokinetic profile, and thereby tumor growth inhibition in a mouse xenograft model upon oral administration.

Uses

DS18561882 is a highly potent, isozyme-selective methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) inhibitor with an IC50 value of 0.0063 μM. DS18561882 also has inhibitory effect on MTHFD1 (IC50=0.57 μM). DS18561882 exhibits a good oral pharmacokinetic profile[1].

in vivo

DS18561882 (oral administration; 30, 100 or 300 mg/kg; twice daily) inhibits tumor growth inhibition with a dose-dependent manner, the tumor is completely inhibited (TGI: 67%) at the dose of 300 mg/kg in mice[1]. DS18561882 (oral administration; 10, 30, 100, or 300 mg/kg) has a good oral pharmacokinetic profile, including ACU (64.6, 264, 726 μg.h/ml ); Cmax (11.4, 56.5, 90.1 μg/ml); t1/2 (2.21, 2.16, 2.32 hours) for 30 mg/kg; 100mg/kg; 200 mg/kg, respectively[1]. DS18561882 is suspended in a 0.5% (w/v) methyl cellulose 400 solution in this article[1].

Animal Model:Five week old female BALB/cAJcl-nu/nu mice with MDA-MB-231 luc tumor cells (4 × 106 cells/mouse)[1]
Dosage:30, 100 or 300 mg/kg
Administration:Oral administration; 30, 100 or 300 mg/kg; twice daily; until day 11
Result:Suppressed tumor growth in a dose-dependent manner.

References

[1] Kawai J, et al. Discovery of a Potent, Selective, and Orally Available MTHFD2 Inhibitor (DS18561882) with In Vivo Anti-Tumor Activity. J Med Chem. 2019 Oct 22. DOI:10.1021/acs.jmedchem.9b01113

DS18561882 Preparation Products And Raw materials

Raw materials

Preparation Products

DS18561882 Suppliers

Global( 24)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32434 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 39031 58
Aladdin Scientific 		tp@aladdinsci.com United States 52924 58
Shanghai Hanhong Scientific Co., Ltd. 		+undefined17612118332 Lucky@hanhonggroup.com China 5844 58
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9803 58
Shanghai Chaolan Chemical Technology Center 021-QQ：65489617 15618227136 Sales@ATKchemical.com China 9954 58
Suzhou Rovathin Foreign Trade Co.,Ltd 0512-65816829 18662214788 info@rovathin.com.cn China 9938 58
Shanghai Dongyang Biotechnology Co., Ltd. 0512-0512-13601744364 13601744364 chemsharker@126.com China 999 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11218 58
Shanghai hongqu biomedical technology co. LTD 88888888888 hongquchem@qq.com China 5132 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
Shanghai Hanhong Scientific Co., Ltd. 		58
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai Chaolan Chemical Technology Center 58
Suzhou Rovathin Foreign Trade Co.,Ltd 58
Shanghai Dongyang Biotechnology Co., Ltd. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Shanghai hongqu biomedical technology co. LTD 58

View Lastest Price from DS18561882 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
DS18561882 pictures 2025-10-13 DS18561882
2227149-22-4
 US $117.00-455.00 / mg 99.25% 10g TargetMol Chemicals Inc.
DS18561882 pictures 2025-10-13 DS18561882
2227149-22-4
 US $117.00-455.00 / mg 99.25% 10g TargetMol Chemicals Inc.
  • DS18561882 pictures
  • DS18561882
    2227149-22-4
  • US $117.00-455.00 / mg
  • 99.25%
  • TargetMol Chemicals Inc.
  • DS18561882 pictures
  • DS18561882
    2227149-22-4
  • US $117.00-455.00 / mg
  • 99.25%
  • TargetMol Chemicals Inc.
DS18561882 Methanesulfonamide, N-[4-[[8-[(3S)-3,4-dimethyl-1-piperazinyl]-1,5-dihydro-7-methyl-5-oxo-2H-[1]benzopyrano[3,4-c]pyridin-3(4H)-yl]carbonyl]-2-(trifluoromethoxy)phenyl]- DS18561882,DS-18561882 (S)-N-(4-(8-(3,4-Dimethylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-(trifluoromethoxy)phenyl)methanesulfonamide 2227149-22-4 C28H31F3N4O6S