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TPX-0131

TPX-0131 Structure
TPX-0131 structure
CAS No.
2648641-36-3
Chemical Name:
TPX-0131
Synonyms
Zotizalkib;(S,14aE,15aE)-13-(difluoromethyl)-35-fluoro-6,6-dimethyl-13,14-dihydro-12H-4-oxa-7-aza-1(4,6)-pyrazolo[1',5':1,2]pyrimido[5,4-b][1,4]oxazina-3(1,2)-benzenacyclooctaphan-8-one;TPX-0131;Zotizalkib ( TPX-0131 );(4S)-4-(Difluoromethyl)-8-fluoro-3,4,13,14-tetrahydro-13,13-dimethyl-18,1-metheno-6H-[1,4]oxazino[3,4-i]pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-15(12H)-one;(18S)-18-(difluoromethyl)-13-fluoro-7,7-dimethyl-9,20-dioxa-1,2,6,17,23-pentaazapentacyclo[19.3.1.0?,2?.01?,1?.01?,22]pentacosa-2,4(24),10(15),11,13,21(25),22-heptaen-5-one;(4S)-4-(Difluoromethyl)-8-fluoro-3,4,13,14-tetrahydro-13,13-dimethyl-18,1-metheno-6H-[1,4]oxazino[3,4-i]pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-15(12H)-one (ACI)
CBNumber:
CB96184741
Molecular Formula:
C21H20F3N5O3
Molecular Weight:
447.42
MDL Number:
MFCD34474251
MOL File:
2648641-36-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-24 14:58:18
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TPX-0131 Properties

Density 1.56±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO:25.0(Max Conc. mg/mL);55.88(Max Conc. mM)
pka 10.52±0.60(Predicted)
form Solid
color White to off-white
InChIKey ILAMRXVQSGVCJX-WDHUHKLTNA-N
SMILES C([C@@H]1COC2=CN3N=CC4C(NC(C)(C)COC5=CC=C(F)C=C5CN1C2=NC3=4)=O)(F)F |&1:1,r|
FDA UNII 5BKJ4Z6RBU

TPX-0131 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0182825 Zotizalkib 98.02% 2648641-36-3 5mg $401 2026-06-04 Buy
ChemScene CS-0182825 Zotizalkib 98.02% 2648641-36-3 10mg $639 2026-06-04 Buy
ChemScene CS-0182825 Zotizalkib 98.02% 2648641-36-3 25mg $1278 2026-06-04 Buy
ChemScene CS-0182825 Zotizalkib 98.02% 2648641-36-3 50mg $2037 2026-06-04 Buy
aablocks AA0221NE TPX-0131 >98% 2648641-36-3 5mg $447 2026-06-01 Buy
Product number Packaging Price Buy
CS-0182825 5mg $401 Buy
CS-0182825 10mg $639 Buy
CS-0182825 25mg $1278 Buy
CS-0182825 50mg $2037 Buy
AA0221NE 5mg $447 Buy

TPX-0131 Chemical Properties, Uses, Production

Uses

Zotizalkib (TPX-0131) is a potent, selective, CNS-penetrant and orally active inhibitor of wild-type ALK (IC50 of 1.4 nM) and ALK-resistant mutation, e.g. G1202R (IC50 of 0.3 nM), L1196M (IC50 of 0.3 nM). Zotizalkib has strong antitumor activities[1].

in vivo

Zotizalkib (2-10 mg/kg; p.o.; twice a day; for 2 weeks) treatment at 2 mg/kg, 5 mg/kg, and 10 mg/kg resulted in dose-dependent tumor growth inhibition (TGI) of 64%, 120%, and 200% (complete regression), respectively[1].

Animal Model:Female SCID/beige mice (5-8 weeks old) bearing Ba/F3 cells[1]
Dosage:2 mg/kg, 5 mg/kg, and 10 mg/kg
Administration:p.o.; twice a day; for 2 weeks
Result:Caused complete tumor regression in ALK mutation-dependent xenograft models.

References

[1] Brion W Murray, et al. TPX-0131, a Potent CNS-Penetrant, Next-Generation Inhibitor of Wild-Type ALK and ALK-Resistant Mutations. Mol Cancer Ther. 2021 Jun 22;molcanther.0221.2021. DOI:10.1158/1535-7163.MCT-21-0221

TPX-0131 Preparation Products And Raw materials

Raw materials

Preparation Products

TPX-0131 Suppliers

Global Suppliers ( 38)
Supplier Tel Email Country ProdList Advantage
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. 17702719238 sales@sun-shinechem.com China 1197 64
ChemCell Biomedicine Co.,Ltd. 020-13556033878 2965585218 13556033878 chemcell@hotmail.com China 369 52
ChemShuttle, Inc. 0510-83588313-811 18800520310 sales@chemshuttle.com China 2999 62
Shanghai Hope Chem Co., Ltd.， +21-18501659228 18501659228 info@hope-chem.com China 538 55
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185 sales-cpd@caerulumpharma.com China 3493 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4859 55
Shanghai Biolang biotechnology Co.,Ltd 17764003753 2326587775@qq.com China 185 55
Shanghai Biolang biotechnology Co.,Ltd 17764003753 2326587775@qq.com China 185 55
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994 2853530910@QQ.com China 8000 62
InvivoChem +1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6378 58
Supplier Advantage
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. 64
ChemCell Biomedicine Co.,Ltd. 52
ChemShuttle, Inc. 62
Shanghai Hope Chem Co., Ltd.， 55
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Shanghai Lollane Biological Technology Co.,Ltd. 55
Shanghai Biolang biotechnology Co.,Ltd 55
Shanghai Biolang biotechnology Co.,Ltd 55
ShangHai Biochempartner Co.,Ltd 62
InvivoChem 58

TPX-0131 Spectrum

TPX-0131(2648641-36-3)1HNMR

2648641-36-3 (TPX-0131) Related Search:

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TPX-0131 Zotizalkib ( TPX-0131 ) (4S)-4-(Difluoromethyl)-8-fluoro-3,4,13,14-tetrahydro-13,13-dimethyl-18,1-metheno-6H-[1,4]oxazino[3,4-i]pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-15(12H)-one (18S)-18-(difluoromethyl)-13-fluoro-7,7-dimethyl-9,20-dioxa-1,2,6,17,23-pentaazapentacyclo[19.3.1.0?,2?.01?,1?.01?,22]pentacosa-2,4(24),10(15),11,13,21(25),22-heptaen-5-one (S,14aE,15aE)-13-(difluoromethyl)-35-fluoro-6,6-dimethyl-13,14-dihydro-12H-4-oxa-7-aza-1(4,6)-pyrazolo[1',5':1,2]pyrimido[5,4-b][1,4]oxazina-3(1,2)-benzenacyclooctaphan-8-one Zotizalkib (4S)-4-(Difluoromethyl)-8-fluoro-3,4,13,14-tetrahydro-13,13-dimethyl-18,1-metheno-6H-[1,4]oxazino[3,4-i]pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-15(12H)-one (ACI) 2648641-36-3 API APIS