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2-Methoxy-4-methylphenol

2-Methoxy-4-methylphenol Structure
2-Methoxy-4-methylphenol structure
CAS No.
93-51-6
Chemical Name:
2-Methoxy-4-methylphenol
Synonyms
CREOSOL;4-METHYLGUAIACOL;4-Methyl-2-methoxyphenol;Phenol, 2-methoxy-4-methyl-;FEMA 2671;2-METHOXY-P-CRESOL;VALSPICE;METHYL GUAIACOL;p-Methylguaiacol;p-Creosol
CBNumber:
CB9667640
Molecular Formula:
C8H10O2
Molecular Weight:
138.16
MDL Number:
MFCD00002378
MOL File:
93-51-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 05:36:59
Product description Number Pack Size Price
2-Methoxy-4-methylphenol natural, 97%, FG W267112 1 each $62.3
2-Methoxy-4-methylphenol natural, 97%, FG W267112 100g $339
2-Methoxy-4-methylphenol ≥98%, FG W267104 1 each $58
2-Methoxy-4-methylphenol natural, 97%, FG W267112 1kg $1690
2-Methoxy-4-methylphenol ≥98%, FG W267104 100g $77.4
More product size
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2-Methoxy-4-methylphenol Properties

Melting point 5 °C (lit.)
Boiling point 221-222 °C (lit.)
Density 1.092 g/mL at 25 °C (lit.)
refractive index n20/D 1.537(lit.)
FEMA 2671 | 2-METHOXY-4-METHYLPHENOL
FLAVIS Number 04.007 | 2-Methoxy-4-methylphenol
Flash point 211 °F
storage temp. Inert atmosphere,Room Temperature
solubility Chloroform (Sparingly), Methanol (Slightly)
form Liquid
pka 10.27±0.18(Predicted)
Specific Gravity 1.091.092
color colorless to light yellow
Odor at 10.00 % in dipropylene glycol. spicy clove vanilla phenolic medicinal leathery woody smoky burnt
Odor Type spicy
biological source synthetic
Water Solubility Slightly soluble in water.
Merck 14,2571
JECFA Number 715
BRN 1862340
Henry's Law Constant 7.7×100 mol/(m3Pa) at 25℃, Sagebiel et al. (1992)
Dielectric constant 11.0
Cosmetics Ingredients Functions PERFUMING
InChI 1S/C8H10O2/c1-6-3-4-7(9)8(5-6)10-2/h3-5,9H,1-2H3
InChIKey PETRWTHZSKVLRE-UHFFFAOYSA-N
SMILES COc1cc(C)ccc1O
LogP 1.65
CAS DataBase Reference 93-51-6(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS) 2-METHOXY-4-METHYLPHENOL
EWG's Food Scores 1-2
FDA UNII W9GW1KZG6N
NIST Chemistry Reference Phenol, 2-methoxy-4-methyl-(93-51-6)
EPA Substance Registry System Phenol, 2-methoxy-4-methyl- (93-51-6)
UNSPSC Code 12352100
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319
Precautionary statements  P264-P270-P280-P301+P312-P302+P352-P305+P351+P338
PPE Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xn,Xi
Risk Statements  22-36/37/38
Safety Statements  26-36-24/25
RIDADR  2810
WGK Germany  3
RTECS  GP1755000
F  10
TSCA  TSCA listed
HazardClass  6.1(a)
PackingGroup  II
HS Code  29095090
Storage Class 10 - Combustible liquids
Hazard Classifications Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
REACH Registrations Inactive
NFPA 704
1
2 0

2-Methoxy-4-methylphenol price More Price(93)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich W267112 2-Methoxy-4-methylphenol natural, 97%, FG 93-51-6 1 each $62.3 2026-04-30 Buy
Sigma-Aldrich W267112 2-Methoxy-4-methylphenol natural, 97%, FG 93-51-6 100g $339 2026-04-30 Buy
Sigma-Aldrich W267104 2-Methoxy-4-methylphenol ≥98%, FG 93-51-6 1 each $58 2026-04-30 Buy
Sigma-Aldrich W267112 2-Methoxy-4-methylphenol natural, 97%, FG 93-51-6 1kg $1690 2026-04-30 Buy
Sigma-Aldrich W267104 2-Methoxy-4-methylphenol ≥98%, FG 93-51-6 100g $77.4 2026-04-30 Buy
Product number Packaging Price Buy
W267112 1 each $62.3 Buy
W267112 100g $339 Buy
W267104 1 each $58 Buy
W267112 1kg $1690 Buy
W267104 100g $77.4 Buy

2-Methoxy-4-methylphenol Chemical Properties,Uses,Production

Description

2-Methoxy-4-methylphenol has a characteristic aromatic odor (sweet, spicy, slightly vanilla-like) and a somewhat bitter taste (vanilla-like). May be prepared by methylation of homopyrocatechin using dimethyl sulfate and alkali; also by hydrogenation of vanillin.

Chemical Properties

2-Methoxy-4-methylphenol is a clear colorless to slightly yellow liquid or viscous, yeelowish oil, solidifying in the cold. The prismatic crystals melt at 6° C. Sp.Gr. 1.10. B.P. 222° C. Very slightly soluble in water, soluble in alcohol and oils. Sweet-spicy, phenolic-leathery odor with distinctly Vanilla-1ike undertones, balsamicwarm sweetness, but overall too medicinal to become classified as a versatile, floral-balsamic ingredient.

Occurrence

Occurs in beechwood tar; also identified in the essential oils of ylang-ylang, jasmine and anise seeds; it is one of the active constituents of creosote. Reported found in Gruyere cheese, smoked fish, cured pork, beer, rum, bourbon whiskey, malt and Scotch whiskey, sherry, white and red wine, cocoa, coffee, tea, mushrooms, mango, pear brandy, malt, wort, dried bonito, Bourbon vanilla, cuttlefish and green maté.

Uses

2-Methoxy-4-methylphenol is used for blending baking and smoked food flavors. Excellent additive and modifier in artificial Ylang-Ylang, Cassie-bases, Jasmin bases, Lily, Gardenia, etc. Finds use in flavor compositions for imitation Vanilla, Clove, various fruit compositions, Rum flavors, etc. and in Nut-Nougat flavor bases. Concentration will be about 0.02 to 1 ppm in the finished consumer product. In beverages, however, it may be as high as 10 to 20 ppm.

Production Methods

With three distinct oxygenated functional groups (aldehyde, ether, and hydroxyl), VAN can undergo selective hydrodeoxygenation to produce 2- methoxy-4-methylphenol (MMP), a promising candidate for future biofuel applications and its use in fragrances and intermediate in pharmaceutical synthesis. Kumar et al. developed stable, cost-effective Ni nanoparticles supported on montmorillonite (MMT) clay, which was synthesized for eco-friendly, alcohol-mediated catalytic transfer hydrodeoxygenation of VAN to MMP. The Ni(10%)/MMT catalyst achieved >99% VAN conversion and 95.2% MMP selectivity using isopropanol (IPA) as a solvent and hydrogen donor[1].

References

[1] Atul Kumar, Prof. Dr. Rajendra Srivastava, Dr. Rajaram Bal. “Ni Nanoparticles Supported Montmorillonite Clay for Selective Catalytic Transfer Hydrodeoxygenation of Vanillin into 2-Methoxy-4-methylphenol.” ChemCatChem 16 9 (2024).

Definition

ChEBI: 2-Methoxy-4-methylphenol is a member of phenols and a member of methoxybenzenes. It is used in preparation of renewable bis(cyanate) esters.

Preparation

By methylation of homopyrocatechin using dimethyl sulfate and alkali; also by hydrogenation of vanillin.

Aroma threshold values

Detection: 90 ppb. Aroma characteristics at 1.0%: smoky, sweet, phenolic, vanilla, spicy clove with a floral carnation nuance.

Taste threshold values

Taste characteristics at 1.0 to 1.25 ppm: sweet phenolic, spice, vanilla, medicinal, clove-like, smoky, guaia col-like with a woody, phenolic nuance.

General Description

2-Methoxy-4-methylphenol is the major component of black-ripe table olive aroma. It is the major anti-inflammatory compound in bamboo vinegar. Kinetics of reaction of 2-methoxy-4-methylphenol with chlorine atoms was studied.

Biochem/physiol Actions

Odor at 1.0%

2-Methoxy-4-methylphenol Preparation Products And Raw materials

Raw materials

4-Methylcatechol Phenol, 2,2'-methylenebis[6-methoxy-4-methyl-

Preparation Products

Catechol 2-METHOXY-5-METHYLPHENOL 3,4-Dimethoxyphenol 2-Isopropyl-5-methylanisole METHOXYBENZOQUINONE
4-Ethylresorcinol 4-Methylanisole p-Cresol 2-[(DIMETHYLAMINO)METHYL]-6-METHOXY-4-METHYLBENZENOL 2,3-DIHYDROXY-5-METHYL-BENZOIC ACID

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2-Methoxy-4-methylphenol Suppliers

Global( 459)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Longbang Technology Co., LTD
+86-18633929156 admin@hblongbang.com China 972 58
Hebei Chuanghai Biotechnology Co., Ltd 		+86-15350571055 Sibel@chuanghaibio.com China 8737 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20111 58
Hebei Zhuanglai Chemical Trading Co.,Ltd 		13343047651 admin@zlchemi.com China 3689 58
Shandong Deshang Chemical Co., Ltd. 		+86-0531-8875-2665 +86-13153039501 info@deshangchem.com China 659 58
JINING XINHE CHEMICAL CO., LTD 		+8615318402391 sales@xinhepharma.com China 808 58
HebeiShuoshengImportandExportco.,Ltd 		+86-18532138899 L18532138899@163.com China 939 58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD 		+86-15350851019; +86-15383190639 admin@86-ss.com China 992 58
Sinoway Industrial co., ltd. 		+86-0592-5800732 +86-13806035118 xie@china-sinoway.com China 1366 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21531 55
Supplier Advantage
Hebei Longbang Technology Co., LTD
58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Henan Fengda Chemical Co., Ltd 		58
Hebei Zhuanglai Chemical Trading Co.,Ltd 		58
Shandong Deshang Chemical Co., Ltd. 		58
JINING XINHE CHEMICAL CO., LTD 		58
HebeiShuoshengImportandExportco.,Ltd 		58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD 		58
Sinoway Industrial co., ltd. 		58
Henan Tianfu Chemical Co.,Ltd. 		55

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View Lastest Price from 2-Methoxy-4-methylphenol manufacturers

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Natural 4-Methyguaiacol pictures 2026-08-07 Natural 4-Methyguaiacol
93-51-6
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2-Methoxy-4-methylphenol pictures 2026-08-07 2-Methoxy-4-methylphenol
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2-Methoxy-4-methylphenol pictures 2026-08-06 2-Methoxy-4-methylphenol
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 $1.20-31.00 1kg 99% Henan Fengda Chemical Co., Ltd

2-Methoxy-4-methylphenol Spectrum

2-Methoxy-4-methylphenol(93-51-6)MS2-Methoxy-4-methylphenol(93-51-6)1HNMR2-Methoxy-4-methylphenol(93-51-6)13CNMR2-Methoxy-4-methylphenol(93-51-6)IR12-Methoxy-4-methylphenol(93-51-6)IR22-Methoxy-4-methylphenol(93-51-6)Raman

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