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2-Methoxy-4-methylphenol

2-Methoxy-4-methylphenol structure

CAS No.: 93-51-6

Chemical Name:: 2-Methoxy-4-methylphenol

Synonyms: CREOSOL;4-METHYLGUAIACOL;Phenol, 2-methoxy-4-methyl-;4-Methyl-2-methoxyphenol;FEMA 2671;2-METHOXY-P-CRESOL;p-Methylguaiacol;VALSPICE;p-Creosol;Homocatechol methyl ester

CBNumber:: CB9667640

Molecular Formula:: C8H10O2

Molecular Weight:: 138.16

MDL Number:: MFCD00002378

MOL File:: 93-51-6.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-10 10:27:34

Product description	Number	Pack Size	Price
2-Methoxy-4-methylphenol natural, 97%, FG	W267112	1 each	$62.3
2-Methoxy-4-methylphenol natural, 97%, FG	W267112	100g	$339
2-Methoxy-4-methylphenol natural, 97%, FG	W267112	1kg	$1690
2-Methoxy-4-methylphenol ≥98%, FG	W267104	1 each	$58
2-Methoxy-4-methylphenol ≥98%, FG	W267104	100g	$77.4
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2-Methoxy-4-methylphenol Properties

Melting point	5 °C (lit.)
Boiling point	221-222 °C (lit.)
Density	1.092 g/mL at 25 °C (lit.)
FEMA	2671 \| 2-METHOXY-4-METHYLPHENOL
FLAVIS Number	04.007 \| 2-Methoxy-4-methylphenol
refractive index	n20/D 1.537(lit.)
Flash point	211 °F
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform (Sparingly), Methanol (Slightly)
pka	10.27±0.18(Predicted)
form	Liquid
color	colorless to light yellow
Specific Gravity	1.091.092
Odor	at 10.00 % in dipropylene glycol. spicy clove vanilla phenolic medicinal leathery woody smoky burnt
Odor Type	spicy
biological source	synthetic
Water Solubility	Slightly soluble in water.
Merck	14,2571
JECFA Number	715
BRN	1862340
Henry's Law Constant	7.7×10⁰ mol/(m³Pa) at 25℃, Sagebiel et al. (1992)
Dielectric constant	11.0
Cosmetics Ingredients Functions	PERFUMING
InChI	1S/C8H10O2/c1-6-3-4-7(9)8(5-6)10-2/h3-5,9H,1-2H3
InChIKey	PETRWTHZSKVLRE-UHFFFAOYSA-N
SMILES	COc1cc(C)ccc1O
LogP	1.65
CAS DataBase Reference	93-51-6(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS)	2-METHOXY-4-METHYLPHENOL
EWG's Food Scores	1-2
FDA UNII	W9GW1KZG6N
NIST Chemistry Reference	Phenol, 2-methoxy-4-methyl-(93-51-6)
EPA Substance Registry System	Phenol, 2-methoxy-4-methyl- (93-51-6)
UNSPSC Code	12352100
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319

Precautionary statements

P264-P270-P280-P301+P312-P302+P352-P305+P351+P338

PPE

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

Xn,Xi

Risk Statements

22-36/37/38

Safety Statements

26-36-24/25

RIDADR

2810

WGK Germany

RTECS

GP1755000

TSCA

TSCA listed

HazardClass

6.1(a)

PackingGroup

HS Code

29095090

Storage Class

10 - Combustible liquids

Hazard Classifications

Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2

NFPA 704

	1
2		0

2-Methoxy-4-methylphenol price More Price(52)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	W267112	2-Methoxy-4-methylphenol natural, 97%, FG	93-51-6	1 each	$62.3	2026-03-19	Buy
Sigma-Aldrich	W267112	2-Methoxy-4-methylphenol natural, 97%, FG	93-51-6	100g	$339	2026-03-19	Buy
Sigma-Aldrich	W267112	2-Methoxy-4-methylphenol natural, 97%, FG	93-51-6	1kg	$1690	2026-03-19	Buy
Sigma-Aldrich	W267104	2-Methoxy-4-methylphenol ≥98%, FG	93-51-6	1 each	$58	2026-03-19	Buy
Sigma-Aldrich	W267104	2-Methoxy-4-methylphenol ≥98%, FG	93-51-6	100g	$77.4	2026-03-19	Buy

Product number	Packaging	Price	Buy
W267112	1 each	$62.3	Buy
W267112	100g	$339	Buy
W267112	1kg	$1690	Buy
W267104	1 each	$58	Buy
W267104	100g	$77.4	Buy

2-Methoxy-4-methylphenol Chemical Properties,Uses,Production

Description

2-Methoxy-4-methylphenol has a characteristic aromatic odor (sweet, spicy, slightly vanilla-like) and a somewhat bitter taste (vanilla-like). May be prepared by methylation of homopyrocatechin using dimethyl sulfate and alkali; also by hydrogenation of vanillin.

Chemical Properties

2-Methoxy-4-methylphenol is a clear colorless to slightly yellow liquid or viscous, yeelowish oil, solidifying in the cold. The prismatic crystals melt at 6° C. Sp.Gr. 1.10. B.P. 222° C. Very slightly soluble in water, soluble in alcohol and oils. Sweet-spicy, phenolic-leathery odor with distinctly Vanilla-1ike undertones, balsamicwarm sweetness, but overall too medicinal to become classified as a versatile, floral-balsamic ingredient.

Occurrence

Occurs in beechwood tar; also identified in the essential oils of ylang-ylang, jasmine and anise seeds; it is one of the active constituents of creosote. Reported found in Gruyere cheese, smoked fish, cured pork, beer, rum, bourbon whiskey, malt and Scotch whiskey, sherry, white and red wine, cocoa, coffee, tea, mushrooms, mango, pear brandy, malt, wort, dried bonito, Bourbon vanilla, cuttlefish and green maté.

Uses

2-Methoxy-4-methylphenol is used for blending baking and smoked food flavors. Excellent additive and modifier in artificial Ylang-Ylang, Cassie-bases, Jasmin bases, Lily, Gardenia, etc. Finds use in flavor compositions for imitation Vanilla, Clove, various fruit compositions, Rum flavors, etc. and in Nut-Nougat flavor bases. Concentration will be about 0.02 to 1 ppm in the finished consumer product. In beverages, however, it may be as high as 10 to 20 ppm.

Production Methods

With three distinct oxygenated functional groups (aldehyde, ether, and hydroxyl), VAN can undergo selective hydrodeoxygenation to produce 2- methoxy-4-methylphenol (MMP), a promising candidate for future biofuel applications and its use in fragrances and intermediate in pharmaceutical synthesis. Kumar et al. developed stable, cost-effective Ni nanoparticles supported on montmorillonite (MMT) clay, which was synthesized for eco-friendly, alcohol-mediated catalytic transfer hydrodeoxygenation of VAN to MMP. The Ni(10%)/MMT catalyst achieved >99% VAN conversion and 95.2% MMP selectivity using isopropanol (IPA) as a solvent and hydrogen donor[1].

References

[1] Atul Kumar, Prof. Dr. Rajendra Srivastava, Dr. Rajaram Bal. “Ni Nanoparticles Supported Montmorillonite Clay for Selective Catalytic Transfer Hydrodeoxygenation of Vanillin into 2-Methoxy-4-methylphenol.” ChemCatChem 16 9 (2024).

Definition

ChEBI: 2-Methoxy-4-methylphenol is a member of phenols and a member of methoxybenzenes. It is used in preparation of renewable bis(cyanate) esters.

Preparation

By methylation of homopyrocatechin using dimethyl sulfate and alkali; also by hydrogenation of vanillin.

Aroma threshold values

Detection: 90 ppb. Aroma characteristics at 1.0%: smoky, sweet, phenolic, vanilla, spicy clove with a floral carnation nuance.

Taste threshold values

Taste characteristics at 1.0 to 1.25 ppm: sweet phenolic, spice, vanilla, medicinal, clove-like, smoky, guaia col-like with a woody, phenolic nuance.

General Description

2-Methoxy-4-methylphenol is the major component of black-ripe table olive aroma. It is the major anti-inflammatory compound in bamboo vinegar. Kinetics of reaction of 2-methoxy-4-methylphenol with chlorine atoms was studied.

Biochem/physiol Actions

Odor at 1.0%

2-Methoxy-4-methylphenol Preparation Products And Raw materials

Raw materials

4-Methylcatechol Phenol, 2,2'-methylenebis[6-methoxy-4-methyl-

Preparation Products

Catechol 2-METHOXY-5-METHYLPHENOL 3,4-Dimethoxyphenol 2-Isopropyl-5-methylanisole METHOXYBENZOQUINONE

4-Ethylresorcinol 4-Methylanisole p-Cresol 2-[(DIMETHYLAMINO)METHYL]-6-METHOXY-4-METHYLBENZENOL 2,3-DIHYDROXY-5-METHYL-BENZOIC ACID

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2-Methoxy-4-methylphenol Suppliers

Global( 447)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Longbang Technology Co., LTD	+86-18633929156	admin@hblongbang.com	China	972	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8738	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20124	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	+8613343047651	admin@zlchemi.com	China	3692	58
Shandong Deshang Chemical Co., Ltd.	+86-0531-8875-2665 +8613153039501	info@deshangchem.com	China	661	58
JINING XINHE CHEMICAL CO., LTD	+8615318402391	sales@xinhepharma.com	China	809	58
HebeiShuoshengImportandExportco.,Ltd	+86-18532138899	L18532138899@163.com	China	939	58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD	+86-15350851019; +8615350851019	admin@86-ss.com	China	999	58
Sinoway Industrial co., ltd.	+86-0592-5800732 +86-13806035118	xie@china-sinoway.com	China	1369	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21592	55

Supplier	Advantage
Hebei Longbang Technology Co., LTD	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Henan Fengda Chemical Co., Ltd	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	58
Shandong Deshang Chemical Co., Ltd.	58
JINING XINHE CHEMICAL CO., LTD	58
HebeiShuoshengImportandExportco.,Ltd	58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD	58
Sinoway Industrial co., ltd.	58
Henan Tianfu Chemical Co.,Ltd.	55

2-Methoxy-4-methylphenol: Synthesis and Multifunctional Applications
2-Methoxy-4-methylphenol serves as biofuel/fragrance, and can be synthesized via non-noble metal catalysis or oxidized to vani....
Oct 13，2025

View Lastest Price from 2-Methoxy-4-methylphenol manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-04-24	2-Methoxy-4-methylphenol 93-51-6	US $3900.00-3500.00 / ton	0.0010000000474974513ton	99%	5000	HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
2026-04-23	Natural 4-Methyguaiacol 93-51-6	US $0.00-0.00 / kg	1kg	99%	20tons	Sinoway Industrial co., ltd.
2026-03-20	2-Methoxy-4-methylphenol 93-51-6	US $10.00 / KG	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd

2-Methoxy-4-methylphenol
93-51-6
US $3900.00-3500.00 / ton
99%
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Natural 4-Methyguaiacol
93-51-6
US $0.00-0.00 / kg
99%
Sinoway Industrial co., ltd.

2-Methoxy-4-methylphenol
93-51-6
US $10.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

2-Methoxy-4-methylphenol Spectrum

2-Methoxy-4-methylphenol(93-51-6)MS 2-Methoxy-4-methylphenol(93-51-6)¹HNMR 2-Methoxy-4-methylphenol(93-51-6)¹³CNMR 2-Methoxy-4-methylphenol(93-51-6)IR1 2-Methoxy-4-methylphenol(93-51-6)IR2 2-Methoxy-4-methylphenol(93-51-6)Raman

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4-hydroxy-3-methoxy-1-methyl-benzene 4-HYDROXY-3-METHOXYTOLUENE 4-METHYLCATECHOL 2-METHYL ETHER 4-METHYLGUAJACOL 1-HYDROXY-2-METHOXY-4-METHYLBENZENE 2-2-Methoxy-4-methylphenol 2-Methoxy-4-methylphenol≥ 99% (GC) 2-Methoxy-4-methylphenol 93-51-6 with low price CAS NO.93-51-6 2-methoxy-4-methyl-pheno 2-Methoxy-4-methylphenol (4-methylguaiacol) 2-methoxy-4-methylphenol (creosol) 2-methoxy-p-creso 3-Methoxy-4-hydroxytoluene 4-Methyl-2-methoxyphenol (4-methylguaiacol) Homocatechol methyl ester Homoguaiacol kreosol p-Creosol p-Cresol, 2-methoxy- Phenol, 4-methyl-2-methoxy p-Methylguaiacol p-methylguaicol Spice level 2-Methoxy-4-methylphenol 2-Methoxy-4-methyL 2-HYDROXY-5-METHYLANISOLE 2-METHOXY-P-CRESOL 2-METHOXY-4-METHYLPHENOL 2-METHOXY-4-CRESOL homocatechol monomethyl ether TIMTEC-BB SBB008258 VALSPICE o-creosol 2-METHOXY-4-METHYLPHENOL 98+% Phenol, 2-methoxy-4-methyl- 4-METHYLGUAICOL PARA-METHYLGUAICOL Cresol(Total) METHYL GUAIACOL 2-Methoxy-p-cresol (OH=1) 2-METHOXY-4-METHYLPHENOL (METHYL GUAIACOL) 4-Hydroxy-3-methylanisol Guaiacylmethane 2-Methoxy-4-methylphenol,99% 2-Methoxy-4-Methylph 2-Methoxy-4-Methylphenol, 99% 25GR VALSPICE, NATURAL 2-Hydroxy-5-methylanisole, 2-Methoxy-p-cresol, 4-Hydroxy-3-methoxytoluene, 4-Methylguaiacol, Creosol 2-Hydroxy-5-methylanisole, 2-Methoxy-p-cresol, Creosol 4-Methyl guaiacol,Natural Creosol 2-Methoxy-p-cresol 4-Methylguaiacol 2-METHOXY-4-METHYLPHENOL FOR SYNTHESIS 2-Methoxy-4-methylphenol/2-Hydroxy-5-methylanisole 2-Methoxy-4-methylphenol> 2-Methoxy-4-methylphenol, 99%, for synthesis 4-Methyguaiacol TIANFU CHEM 93-51-6 2-Methoxy-4-methylphenol 2-Methoyl-4- methylphenol Creosol, 10 mM in DMSO