3-beta,5-alpha-Tetrahydrodeosoxycorticosterone
- CAS No.
- 567-01-1
- Chemical Name:
- 3-beta,5-alpha-Tetrahydrodeosoxycorticosterone
- Synonyms
- 3β,5α-THDOC;5α-PREGNAN-3β, 21-DIOL-20-ONE;5-A-pregnane-3-B-21-diol-20-one;3β,5α-Tetrahydrodeoxycorticosterone;32,21-Dihydroxy-5±-pregnan-20-one-d4;3β,5α-Tetrahydrodesoxycorticosterone;"3β,5a-Tetrahydrodeoxycorticosterone";5-ALPHA-PREGNAN-3-BETA, 21-DIOL-20-ONE;3beta,5alpha-Tetrahydrodeoxycorticosterone;3-beta,5-alfa-Tetrahydrodeoxycorticosterone
- CBNumber:
- CB9676121
- Molecular Formula:
- C21H34O3
- Molecular Weight:
- 334.49
- MDL Number:
- MFCD00069492
- MOL File:
- 567-01-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
3-beta,5-alpha-Tetrahydrodeosoxycorticosterone price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 18431 | 3β,5α-THDOC ≥95% | 567-01-1 | 1mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 18431 | 3β,5α-THDOC ≥95% | 567-01-1 | 5mg | $77 | 2026-04-30 | Buy |
| Cayman Chemical | 18431 | 3β,5α-THDOC ≥95% | 567-01-1 | 10mg | $135 | 2026-04-30 | Buy |
| Cayman Chemical | 18431 | 3β,5α-THDOC ≥95% | 567-01-1 | 25mg | $294 | 2026-04-30 | Buy |
| Biosynth | AAA56701 | 3²,21-Dihydroxy-5±-pregnan-20-one-d4 | 567-01-1 | 25mg | $1096 | 2026-06-04 | Buy |
3-beta,5-alpha-Tetrahydrodeosoxycorticosterone Chemical Properties, Uses, Production
Description
3β,5α-THDOC is a neurosteroid. It inhibits seizures induced by pilocarpine, but not pentylenetetrazol (PTZ; ), in mice (ED50s = 45.9 and >100 mg/kg, respectively). 3β,5α-THDOC has been found in the urine of women during the third trimester of pregnancy.
Uses
3β,5α-Tetrahydrodeoxycorticosterone is a novel derivative of the steroid Dehydroepiandrosterone (DHEA), a known uncompetitive inhibitor of Glucose 6-Phosphate Dehydrogenase (G6PD). Studies have shown that 3β,5α-Tetrahydrodeoxycorticosterone may have potential function in the modulation of calcium and GABAA-gated chloride channel currents found in rat and guinea-pig neurons.
in vitro
epiallopregnanolone showed no effects on the gaba-mediated chloride flux through several types of recombinant gaba receptors. epiallopregnanolone inhibited the allopregnanolone-stimulated gaba-mediated chloride flux through gabaa receptors. epiallopregnanolone antagonized the inhibitory effects of allopregnanolone and ethanol on the population spike in the ca1 region of the hippocampal brain slices [1]. epiallopregnanolone selectively blocked the allopregnanolone inhibition of the population spike in the rat hippocampal ca1[3].
in vivo
in rats trained to discriminate either 0.8g/kg or 1.2 g/kg ethanol, 100 mg/kg epiallopregnanolone treatment decreased the maximum effect by 40% and 54% ethanol lever, respectively. epiallopregnanolone significantly decreased response rates when compared with control condition [1].
References
[1] ginsburg b c, lamb r j. alphaxalone and epiallopregnanolone in rats trained to discriminate ethanol[j]. alcoholism: clinical and experimental research, 2005, 29(9): 1621-1629.
[2] macdonald r l, olsen r w. gabaa receptor channels[j]. annual review of neuroscience, 1994, 17(1): 569-602.
[3] wang m, bckstrm t, landgren s. epiallopregnanolone selectively blocks the allopregnanolone inhibition of the population spike in the rat hippocampal ca1[j]. acta physiologica scandinavica, 1999, 167(2): a5-a5.
3-beta,5-alpha-Tetrahydrodeosoxycorticosterone Preparation Products And Raw materials
Raw materials
Preparation Products
3-beta,5-alpha-Tetrahydrodeosoxycorticosterone Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9909 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 57336 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8137 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44871 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 13675144456 | sean.lv@synzest.com | China | 10778 | 58 |
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