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1,3,5[10]-ESTRATRIENE-3,16ALPHA-DIOL-17-ONE

1,3,5[10]-ESTRATRIENE-3,16ALPHA-DIOL-17-ONE structure

CAS No.: 566-76-7

Chemical Name:: 1,3,5[10]-ESTRATRIENE-3,16ALPHA-DIOL-17-ONE

Synonyms: C05300;16α-OHE1;16A-hydroxyestrone;Estriol Impurity H;16α-hydroxy Estrone;Hydroxyestrone, 16α-;Estriol EP Impurity H;16ALPHA-HYDROXYESTRONE;16ALPHA-HYDROXYESTERONE;16α-Hydroxyestrone (solution)

CBNumber:: CB9688380

Molecular Formula:: C18H22O3

Molecular Weight:: 286.37

MDL Number:: MFCD00870436

MOL File:: 566-76-7.mol

MSDS File:: SDS

Last updated:2025-08-20 16:56:28

Product description	Number	Pack Size	Price
16α-Hydroxyestrone 100?μg/mL in methanol, certified reference material, ampule of 1?mL, Cerilliant?	H-126	1ML	$462
16α-hydroxy Estrone ≥98%	15208	1mg	$121
16α-hydroxy Estrone ≥98%	15208	5mg	$423
16α-hydroxy Estrone ≥98%	15208	10mg	$662
16α-HydroxyEstrone	H941900	10mg	$550
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1,3,5[10]-ESTRATRIENE-3,16ALPHA-DIOL-17-ONE Properties

Melting point	209-211°C
Boiling point	493.2±45.0 °C(Predicted)
Density	1.249±0.06 g/cm3(Predicted)
storage temp.	-20°C Freezer
solubility	DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
form	Solid
pka	10.23±0.60(Predicted)
color	White to Light Beige
FDA UNII	JY611949JU

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS02,GHS06,GHS08
Signal word	Danger
Hazard statements	H225-H301+H311+H331-H370
Precautionary statements	P210-P280-P302+P352+P312-P304+P340+P311-P370+P378-P403+P235
Hazard Codes	Xn
Risk Statements	40
Safety Statements	22-36
WGK Germany	3

1,3,5[10]-ESTRATRIENE-3,16ALPHA-DIOL-17-ONE price More Price(11)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	H-126	16α-Hydroxyestrone 100?μg/mL in methanol, certified reference material, ampule of 1?mL, Cerilliant?	566-76-7	1ML	$462	2022-05-15	Buy
Cayman Chemical	15208	16α-hydroxy Estrone ≥98%	566-76-7	1mg	$121	2024-03-01	Buy
Cayman Chemical	15208	16α-hydroxy Estrone ≥98%	566-76-7	5mg	$423	2024-03-01	Buy
Cayman Chemical	15208	16α-hydroxy Estrone ≥98%	566-76-7	10mg	$662	2024-03-01	Buy
TRC	H941900	16α-HydroxyEstrone	566-76-7	10mg	$550	2021-12-16	Buy

Product number	Packaging	Price	Buy
H-126	1ML	$462	Buy
15208	1mg	$121	Buy
15208	5mg	$423	Buy
15208	10mg	$662	Buy
H941900	10mg	$550	Buy

1,3,5[10]-ESTRATRIENE-3,16ALPHA-DIOL-17-ONE Chemical Properties,Uses,Production

Description

The naturally-occurring estrogens are estrone (E₁, ), estradiol (E₂, ), and estriol (E₃, ). 16α-hydroxy Estrone (16α-OHE₁) is a hydroxylated metabolite of E₁ as well as an interconversion product with E₂. E₁ is 16α-hydroxylated by cytochrome P450 (CYP) isoforms, including CYP1A1, CYP3A5, CYP3A4, and CYP3A7, with CYP3A5 being breast-specific. 16α-OHE₁ is sulphatized or glucuronidated before excretion. It is increased in rheumatoid arthritis and decreased by physical activity. Unlike the parent estrogens and other hydroxylated metabolites of E₁, 16α-OHE₁ binds covalently and persistently activates estrogen receptors. In addition, this metabolite increases cell proliferation and does not suppress TNF-α secretion, whereas other estrogen metabolites are not pro-proliferative and have marked effects on TNF-α secretion. The levels of 16α-OHE₁ are increased in some forms of hormone therapy. Because hormone therapy increases breast cancer risk, 16α-OHE₁ has been implicated as a risk factor for breast cancer, although supportive data remains elusive.

Chemical Properties

Pale Pink Solid

Uses

16α-Hydroxy Estrone (Estriol EP Impurity H) is a major metabolite of Estradiol.

Definition

ChEBI: The 16alpha-hydroxy derivative of estrone; a minor estrogen metabolite.

IC 50

Human Endogenous Metabolite

References

[1] MAURIZIO CUTOLO Rainer H S Alberto Sulli. Estrogen metabolism and autoimmunity[J]. Autoimmunity reviews, 2012, 11 6: Pages A460-A464. DOI: 10.1016/j.autrev.2011.11.014
[2] CHARLES E MATTHEWS. Association between physical activity and urinary estrogens and estrogen metabolites in premenopausal women.[J]. Journal of Clinical Endocrinology & Metabolism, 2012, 97 10: 3724-3733. DOI: 10.1210/jc.2012-1732
[3] NADIA OBI. Estrogen metabolite ratio: Is the 2-hydroxyestrone to 16α-hydroxyestrone ratio predictive for breast cancer[J]. International Journal of Women’s Health, 2011, 3: 37-51. DOI: 10.2147/ijwh.s7595
[4] G E SWANECK J F. Covalent binding of the endogenous estrogen 16 alpha-hydroxyestrone to estradiol receptor in human breast cancer cells: characterization and intranuclear localization.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1988, 85 21: 7831-7835. DOI: 10.1073/pnas.85.21.7831
[5] RACHEL H MACKEY. Hormone therapy, estrogen metabolism, and risk of breast cancer in the Women’s Health Initiative Hormone Therapy Trial.[J]. Cancer epidemiology, biomarkers & prevention: a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2012: 2022-2032. DOI: 10.1158/1055-9965.epi-12-0759
[6] M N OKOBIA C H B. Estrogen metabolism and breast cancer risk–a review.[J]. African journal of reproductive health, 2006, 10 1: 13-25.

1,3,5[10]-ESTRATRIENE-3,16ALPHA-DIOL-17-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

1,3,5[10]-ESTRATRIENE-3,16ALPHA-DIOL-17-ONE Suppliers

Global( 67)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569266 +86-17392581500	1015@dideu.com	China	3986	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52722	58
GIHI CHEMICALS CO.,LIMITED	+86-571-86217390; +8618058761490	info@gihichemicals.com	China	49966	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+86-18621343501; +undefined18621343501	product@acmec-e.com	China	33324	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58
SHANGHAI KEAN TECHNOLOGY CO., LTD.	+8613817748580	cooperation@kean-chem.com	China	40066	58
Moxin Chemicals	+86-17320513646 +8617320513646	anna@molcoo.com	China	10000	58
J & K SCIENTIFIC LTD.	18210857532; 18210857532	jkinfo@jkchemical.com	China	96815	76
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32321	50
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	12952	65

Supplier	Advantage
Shaanxi Dideu Medichem Co. Ltd	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
GIHI CHEMICALS CO.,LIMITED	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
Aladdin Scientific	58
SHANGHAI KEAN TECHNOLOGY CO., LTD.	58
Moxin Chemicals	58
J & K SCIENTIFIC LTD.	76
Chemsky（shanghai）International Co.,Ltd.	50
BOC Sciences	65

566-76-7(1,3,5[10]-ESTRATRIENE-3,16ALPHA-DIOL-17-ONE)Related Search:

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