3-Quinuclidinol
- CAS No.
- 1619-34-7
- Chemical Name:
- 3-Quinuclidinol
- Synonyms
- QUINUCLIDIN-3-OL;Quinuclidinol;3-HYDROXYQUINUCLIDINE;Quinuclidine-3-ol;3-Hydroxy-1-azabicyclo[2.2.2]octane;(3R)-1-azabicyclo[2.2.2]octan-3-ol (3-quinuclidinol);BENC-002;NSC 93905;Quinuclidinol-3;3-QUINUCLIDINOL
- CBNumber:
- CB9694138
- Molecular Formula:
- C7H13NO
- Molecular Weight:
- 127.18
- MDL Number:
- MFCD00151326
- MOL File:
- 1619-34-7.mol
- MSDS File:
- SDS
| Melting point | 220-223 °C(lit.) |
|---|---|
| Boiling point | 235.98°C (rough estimate) |
| Density | 1.0083 (rough estimate) |
| refractive index | 1.4790 (estimate) |
| storage temp. | 2-8°C |
| solubility | Aqueous Acidic (Slightly), Chloroform (Sparingly), Methanol (Slightly) |
| form | Crystalline Powder |
| pka | 14.75±0.20(Predicted) |
| color | White to beige |
| Water Solubility | soluble |
| Sensitive | Air Sensitive |
| Merck | 14,8082 |
| BRN | 104327 |
| Henry's Law Constant | 1.7×103 mol/(m3Pa) at 25℃, Du et al. (2017) |
| LogP | 0.17 |
| CAS DataBase Reference | 1619-34-7(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 974MVZ0WOK |
| NIST Chemistry Reference | 3-Quinuclidinol(1619-34-7) |
| EPA Substance Registry System | 1-Azabicyclo[2.2.2]octan-3-ol (1619-34-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314 | |||||||||
| Precautionary statements | P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363 | |||||||||
| Hazard Codes | C,F | |||||||||
| Risk Statements | 34-11 | |||||||||
| Safety Statements | 26-36/37/39-45-16 | |||||||||
| RIDADR | UN 3263 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | VD6191700 | |||||||||
| F | 34 | |||||||||
| Hazard Note | Corrosive | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29333920 | |||||||||
| Hazardous Substances Data | 1619-34-7(Hazardous Substances Data) | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
3-Quinuclidinol price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 253340 | 3-Quinuclidinol 99% | 1619-34-7 | 5g | $66.1 | 2026-04-30 | Buy |
| Sigma-Aldrich | 253340 | 3-Quinuclidinol 99% | 1619-34-7 | 25g | $162 | 2026-04-30 | Buy |
| Usbiological | 426646 | 3-Quinuclidinol-d7 | 1619-34-7 | 5mg | $403 | 2026-06-03 | Buy |
| Usbiological | 426646 | 3-Quinuclidinol-d7 | 1619-34-7 | 25mg | $941 | 2026-06-03 | Buy |
| Usbiological | 288482 | 3-Quinuclidinol ≥98.5% | 1619-34-7 | 5g | $297 | 2026-06-03 | Buy |
3-Quinuclidinol Chemical Properties, Uses, Production
Chemical Properties
Crystalline Solid
Uses
Hypotensive. Synthon for preparation of cholinergic receptor ligands and anesthetics
Uses
3-Quinuclidinol acts as a chiral building block for various antimuscarinic agents and other active pharmaceutical ingredients. It serves as a catalyst for condensation of methyl vinyl ketone with aldehydes. It is also used as a reagent for cleavage of beta-keto and vinylogous beta-keto esters. Further, it plays an important role as a synthon in the preparation of cholinergic receptor ligands and anesthetics. In addition to this, it is used in chemoselective alfa-iodination of acrylic esters through Morita-Baylis-Hillman reaction.
Definition
ChEBI: Quinuclidine in which a hydrogen atom at position 3 is substituted by a hydroxy group.
Hazard
Mutation.
3-Quinuclidinol Preparation Products And Raw materials
Raw materials
Preparation Products
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