|
|
| | 3-Quinuclidinol Basic information |
| | 3-Quinuclidinol Chemical Properties |
| Melting point | 220-223 °C(lit.) | | Boiling point | 235.98°C (rough estimate) | | density | 1.0083 (rough estimate) | | refractive index | 1.4790 (estimate) | | storage temp. | 2-8°C | | solubility | Aqueous Acidic (Slightly), Chloroform (Sparingly), Methanol (Slightly) | | form | Crystalline Powder | | pka | 14.75±0.20(Predicted) | | color | White to beige | | Water Solubility | soluble | | Sensitive | Air Sensitive | | Merck | 14,8082 | | BRN | 104327 | | Henry's Law Constant | 1.7×103 mol/(m3Pa) at 25℃, Du et al. (2017) | | LogP | 0.17 | | CAS DataBase Reference | 1619-34-7(CAS DataBase Reference) | | NIST Chemistry Reference | 3-Quinuclidinol(1619-34-7) | | EPA Substance Registry System | 1-Azabicyclo[2.2.2]octan-3-ol (1619-34-7) |
| | 3-Quinuclidinol Usage And Synthesis |
| Chemical Properties | Crystalline Solid | | Uses | Hypotensive. Synthon for preparation of cholinergic receptor ligands and anesthetics | | Uses | 3-Quinuclidinol acts as a chiral building block for various antimuscarinic agents and other active pharmaceutical ingredients. It serves as a catalyst for condensation of methyl vinyl ketone with aldehydes. It is also used as a reagent for cleavage of beta-keto and vinylogous beta-keto esters. Further, it plays an important role as a synthon in the preparation of cholinergic receptor ligands and anesthetics. In addition to this, it is used in chemoselective alfa-iodination of acrylic esters through Morita-Baylis-Hillman reaction. | | Definition | ChEBI: Quinuclidine in which a hydrogen atom at position 3 is substituted by a hydroxy group. | | Hazard | Mutation. |
| | 3-Quinuclidinol Preparation Products And Raw materials |
|