3-Quinuclidinol

3-Quinuclidinol Basic information

Product Name:	3-Quinuclidinol
Synonyms:	3-Hydroxyxinyclidine;dl-3-Quinuclidinol;NSC 93905;1-Azabicyclo[2.2.2]octan-3-ol, 3-Hydroxyquinuclidine;QUINICLIDINE-3-OL;3-Quinuclidinol,99%;2-Amino-N-ethylbenze;Quinuclidin-3-ol, 1-Azabicyclo[2.2.2]octan-3-ol
CAS:	1619-34-7
MF:	C7H13NO
MW:	127.18
EINECS:	216-578-4
Product Categories:	Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceutical material and intermeidates;Quinuclidine derivatives
Mol File:	1619-34-7.mol

3-Quinuclidinol Chemical Properties

Melting point	220-223 °C(lit.)
Boiling point	235.98°C (rough estimate)
density	1.0083 (rough estimate)
refractive index	1.4790 (estimate)
storage temp.	2-8°C
solubility	Aqueous Acidic (Slightly), Chloroform (Sparingly), Methanol (Slightly)
pka	14.75±0.20(Predicted)
form	Crystalline Powder
color	White to beige
Water Solubility	soluble
Sensitive	Air Sensitive
Merck	14,8082
BRN	104327
LogP	0.17
CAS DataBase Reference	1619-34-7(CAS DataBase Reference)
NIST Chemistry Reference	3-Quinuclidinol(1619-34-7)
EPA Substance Registry System	1-Azabicyclo[2.2.2]octan-3-ol (1619-34-7)

Safety Information

MSDS Information

3-Quinuclidinol Usage And Synthesis

Chemical Properties	Crystalline Solid
Uses	Hypotensive. Synthon for preparation of cholinergic receptor ligands and anesthetics
Uses	3-Quinuclidinol acts as a chiral building block for various antimuscarinic agents and other active pharmaceutical ingredients. It serves as a catalyst for condensation of methyl vinyl ketone with aldehydes. It is also used as a reagent for cleavage of beta-keto and vinylogous beta-keto esters. Further, it plays an important role as a synthon in the preparation of cholinergic receptor ligands and anesthetics. In addition to this, it is used in chemoselective alfa-iodination of acrylic esters through Morita-Baylis-Hillman reaction.
Definition	ChEBI: Quinuclidine in which a hydrogen atom at position 3 is substituted by a hydroxy group.
Hazard	Mutation.

3-Quinuclidinol Preparation Products And Raw materials

Tag:3-Quinuclidinol(1619-34-7) Related Product Information

Cyproconazol QUINUCLIDINE Quinine sulfate dihydrate (R )-(-)-3-hydroxyquinuclidine (R)-()-3-Quinuclidinol,(R)-3-QUINUCLIDINOL,(R)-(-)-3-Quinuclidinol, 99+%,(R)-(-)-3-QUINUCLIDINOL (S)-3-Quinuclidinol. Hydrochloride,(S)-(+)-3-QUINUCLIDINOL Quinine dihydrochloride 2,2,4-Trimethylpentane 3-Quinuclidinone hydrochloride Solifenacin Related Compound 18 1-Phenyl-3,4-dihydroisoquinoline Solifenacin N-Oxide Solifenacin Impurity 1 HCl Solifenacin Related CoMpound 4 Succinate Solifenacin Related Compound 3 Succinate Solifenacin Related Compound 19 Solifenacin Impurity 2 Solifenacin Related Compound 25 Solifenacin Related Compound 29 Quinuclidinol

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