N-BOC-1,3-DIAMINO-2-PROPANOL
- CAS No.
- 144912-84-5
- Chemical Name:
- N-BOC-1,3-DIAMINO-2-PROPANOL
- Synonyms
- N-BOC-1,3-DIAMINO-2-PROPANOL;3-(Boc-amino)-1-amino-2-propanol;tert-butyl 3-amino-2-hydroxypropylcarbamate;ert-butylN-(3-amino-2-hydroxypropyl)carbamate;Tert-butyl n-(3-amino-2-hydroxypropyl)carbamate;Carbamic acid,N-(3-amino-2-hydroxypropyl)-, 1,1-dimethylethyl ester;Carbamic acid, (3-amino-2-hydroxypropyl)-, 1,1-dimethylethyl ester (9CI)
- CBNumber:
- CB9697654
- Molecular Formula:
- C8H18N2O3
- Molecular Weight:
- 190.24
- MDL Number:
- MFCD04118107
- MOL File:
- 144912-84-5.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| tert-butyl N-(3-amino-2-hydroxypropyl)carbamate | UFA91284 | 5g | $413 |
| tert-butyl N-(3-amino-2-hydroxypropyl)carbamate | UFA91284 | 50g | $1770 |
| tert-Butyl (3-amino-2-hydroxypropyl)carbamate 95+% | B47203 | 250mg | $31 |
| tert-Butyl (3-amino-2-hydroxypropyl)carbamate 95+% | B47203 | 1g | $80 |
| tert-Butyl (3-amino-2-hydroxypropyl)carbamate 95+% | B47203 | 5g | $230 |
| Melting point | 77-79 °C |
|---|---|
| Boiling point | 350.2±32.0 °C(Predicted) |
| Density | 1.090±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| pka | 12.22±0.46(Predicted) |
| Appearance | Off-white to light yellow Solid |
| optical activity | Consistent with structure |
| InChI | InChI=1S/C8H18N2O3/c1-8(2,3)13-7(12)10-5-6(11)4-9/h6,11H,4-5,9H2,1-3H3,(H,10,12) |
| InChIKey | LZNOKWJGNPKUSE-UHFFFAOYSA-N |
| SMILES | C(OC(C)(C)C)(=O)NCC(O)CN |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
N-BOC-1,3-DIAMINO-2-PROPANOL price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | UFA91284 | tert-butyl N-(3-amino-2-hydroxypropyl)carbamate | 144912-84-5 | 5g | $413 | 2026-06-05 | Buy |
| Biosynth | UFA91284 | tert-butyl N-(3-amino-2-hydroxypropyl)carbamate | 144912-84-5 | 50g | $1770 | 2026-06-05 | Buy |
| Synthonix | B47203 | tert-Butyl (3-amino-2-hydroxypropyl)carbamate 95+% | 144912-84-5 | 250mg | $31 | 2026-05-06 | Buy |
| Synthonix | B47203 | tert-Butyl (3-amino-2-hydroxypropyl)carbamate 95+% | 144912-84-5 | 1g | $80 | 2026-05-06 | Buy |
| Synthonix | B47203 | tert-Butyl (3-amino-2-hydroxypropyl)carbamate 95+% | 144912-84-5 | 5g | $230 | 2026-05-06 | Buy |
N-BOC-1,3-DIAMINO-2-PROPANOL Chemical Properties,Uses,Production
Synthesis
24424-99-5
616-29-5
144912-84-5
The general procedure for the synthesis of tert-butyl (3-amino-2-hydroxypropyl)carbamate from di-tert-butyl dicarbonate and 1,3-diamino-2-propanol was as follows: 0.9 g of 1,3-diamino-2-propanol was added to a reactor equipped with magnetic stirring, and dissolved with 5 mL of 1 M sodium hydroxide solution. Subsequently, 1.0 g of di-tert-butyl dicarbonate was dissolved in 5 mL of 1,4-dioxane and this solution was slowly added dropwise to the reactor. The reaction mixture was stirred at room temperature for 5 hours and then warmed up to 50-65 °C for decompression distillation to remove most of the solvent, and the remaining solvent was dried by a vacuum pump to give a white viscous solid. The crude product was purified by silica gel column chromatography with gradient elution using dichloromethane-methanol-triethylamine (300:30:1, v/v/v) as eluent to give 600 mg of tert-butyl (3-amino-2-hydroxypropyl)carbamate in 69% yield.
References
[1] Patent: CN106893342, 2017, A. Location in patent: Paragraph 0016; 0017
[2] Patent: CN105503920, 2016, A. Location in patent: Paragraph 0011; 0057; 0058
[3] Journal of Medicinal Chemistry, 1998, vol. 41, # 2, p. 236 - 246
[4] Organic and Biomolecular Chemistry, 2014, vol. 12, # 46, p. 9389 - 9404
[5] Patent: WO2005/66172, 2005, A1. Location in patent: Page/Page column 62
N-BOC-1,3-DIAMINO-2-PROPANOL Preparation Products And Raw materials
Raw materials
Preparation Products
N-BOC-1,3-DIAMINO-2-PROPANOL Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alfa Chemistry | +1-5166625404; | Info@alfa-chemistry.com | United States | 20000 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 +86-15355479329 | market18@leapchem.com | China | 43303 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 54746 | 58 | |
| Shanghai Kaimo Pharmaceutical Co., Ltd. | 021-50521023 18019779209 | sales@kaimopharm.com | China | 227 | 58 |
| Baimei Jihua (Henan) Pharmaceutical Technology Co., Ltd | 0371-88900765 18037465274 | 3430974218@qq.com | China | 14168 | 58 |
| Shanghai Targsense Scientific Co., Ltd. | 18916626092 | sales@targsense.com | China | 22 | 58 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Chengdu Forest Science and Technology Development Co., Ltd. | 18030648795 18030648795 | sales@cdforestchem.com | China | 1993 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 13636370518 | shyysw007@163.com | China | 89667 | 60 |
| Qingdao IniKem BioPharmaTech Co.,Ltd | 0532-58268781 18561687109 | sales@inikem.com | China | 298 | 55 |
144912-84-5(N-BOC-1,3-DIAMINO-2-PROPANOL)Related Search:
1of4
