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2-Amino-3-cyanothiophene

2-Amino-3-cyanothiophene Structure
2-Amino-3-cyanothiophene structure
CAS No.
4651-82-5
Chemical Name:
2-Amino-3-cyanothiophene
Synonyms
2-AMINOTHIOPHENE-3-CARBONITRILE;AKOS 92285;AKOS B014697;Compound Fr16663;AKOS BBS-00006621;BUTTPARK 36\18-34;ART-CHEM-BB B014697;TIMTEC-BB SBB005484;2-Amino-3-cyanothiophene;2-AMINIO-3-CYANOTHIOPHENE
CBNumber:
CB9733617
Molecular Formula:
C5H4N2S
Molecular Weight:
124.16
MDL Number:
MFCD00706298
MOL File:
4651-82-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:56:34
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2-Amino-3-cyanothiophene Properties

Melting point 104-108 °C
Boiling point 318℃
Density 1.33
Flash point 146℃
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
form powder to crystalline
pka -0.28±0.10(Predicted)
color White to Light yellow to Light orange
InChI InChI=1S/C5H4N2S/c6-3-4-1-2-8-5(4)7/h1-2H,7H2
InChIKey XVGHZFWFGXDIOU-UHFFFAOYSA-N
SMILES C1(N)SC=CC=1C#N
CAS DataBase Reference 4651-82-5(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Exclamation Mark (GHS07)
GHS05,GHS07
Signal word  Danger
Hazard statements  H302-H315-H318-H335
Precautionary statements  P280-P301+P312+P330-P302+P352-P305+P351+P338+P310
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes  Xi,Xn
Risk Statements  20/21/22-36/37/38-41-37/38-22
Safety Statements  36/37-39-26
RIDADR  3439
WGK Germany  3
HazardClass  IRRITANT
HS Code  2934999090
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

2-Amino-3-cyanothiophene price More Price(98)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 681067 2-Aminothiophene-3-carbonitrile 97% 4651-82-5 1g $62.9 2026-04-30 Buy
Sigma-Aldrich 681067 2-Aminothiophene-3-carbonitrile 97% 4651-82-5 5g $126 2026-04-30 Buy
TCI Chemical A2488 2-Amino-3-cyanothiophene >98.0%(GC) 4651-82-5 5g $61 2026-04-30 Buy
Usbiological 261131 2-Amino-3-cyanothiophene Asreported 4651-82-5 25g $363 2026-06-03 Buy
Usbiological 261131 2-Amino-3-cyanothiophene Asreported 4651-82-5 50g $581 2026-06-03 Buy
Product number Packaging Price Buy
681067 1g $62.9 Buy
681067 5g $126 Buy
A2488 5g $61 Buy
261131 25g $363 Buy
261131 50g $581 Buy

2-Amino-3-cyanothiophene Chemical Properties, Uses, Production

Synthesis

2-AMINO-3-CYANOTHIOPHENE is a pharmaceutical intermediate that can be prepared in one step from 1,4-dithiane-2,5-diol and malononitrile. It has been reported in the literature as a potential candidate for preparing HPK1 inhibitors.

Synthesis of 4651-82-5

The starting material 1,4-dithiaran-2,5-diol (100 g, 0.66 mol, 1.0 eq) was dissolved in methanol (500 mL), followed by the addition of malononitrile (86.86 g, 1.32 mol, 2.0 eq) and triethylamine (20 mL). The reaction was carried out at 70 °C for 30 minutes. The reaction was confirmed to be complete by TLC. The reaction solution was concentrated, and the crude product was purified by silica gel column chromatography (PE:EA = 4:1) to obtain a yellow solid product (80 g, yield: 98%).

Uses

2-Aminothiophene-3-carboxynitrile is a pharmaceutical intermediate. Due to its important role in immunity, HPK1 inhibitors play an important role in malignant solid tumors or hematological malignancies (such as acute myeloid leukemia, bladder epithelial carcinoma, breast cancer, colon cancer, lung cancer, pancreatic cancer, melanoma), autoimmune diseases (such as systemic lupus erythematosus, psoriatic arthritis), and inflammatory responses.

Chemical Properties

white to light yellow crystal powder

2-Amino-3-cyanothiophene synthesis

75-07-0
109-77-3
4651-82-5
Synthesis of 2-Amino-3-cyanothiophene from Acetaldehyde and Malononitrile

2-Amino-3-cyanothiophene Preparation Products And Raw materials

Raw materials

2,5-Dihydroxy-1,4-dithiane Acetaldehyde Malononitrile

Preparation Products

5-bromo-4-chlorothieno[2,3-d]pyrimidine 2,4-Dihydroxythieno[2,3-d]pyrimidine 4-chloro-2-(chloromethyl)thieno[2,3-d]pyrimidine 4-Bromo-3-(4H-1,2,4-triazol-3-yl)thiophen-2-amine 4-Chloro-2-(trifluoroMethyl)thieno[2,3-d]pyriMidine
5-BroMo-4-hydrazinylthieno[2,3-d]pyriMidine

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2-Amino-3-cyanothiophene Suppliers

Global Suppliers ( 197)
Supplier Tel Email Country ProdList Advantage
Nantong Flying Pharmtech Co., Ltd. 13270692087 2488110388@qq.com China 32 58
Shanghai TBBMed Co.,Ltd 021-50498136 13564881053 products@tbbmed.com China 180 55
Shandong Xpharm. Co.,LTD 0531-18865936929 18865936929 sales@xpharm.com.cn China 200 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
TAIYUAN RHF CO.,LTD. +86 351 7031519 sales@RHFChem.com China 2334 56
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. +86-21-54098501 sales@sinch.com.cn China 11592 64
Supplier Advantage
Nantong Flying Pharmtech Co., Ltd. 58
Shanghai TBBMed Co.,Ltd 55
Shandong Xpharm. Co.,LTD 58
J & K SCIENTIFIC LTD. 76
TAIYUAN RHF CO.,LTD. 56
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
Capot Chemical Co., Ltd 66
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. 64

View Latest Price from 2-Amino-3-cyanothiophene manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-AMINO-3-CYANOTHIOPHENE pictures 2026-08-20 2-AMINO-3-CYANOTHIOPHENE
4651-82-5
 $1.10 1g 99.00% 100 Tons Dideu Industries Group Limited
2-Amino-3-cyanothiophene pictures 2024-02-19 2-Amino-3-cyanothiophene
4651-82-5
 $350.00 1g 98 500 Kg R&D Scientific Inc.
2-AMINO-3-CYANOTHIOPHENE pictures 2019-07-06 2-AMINO-3-CYANOTHIOPHENE
4651-82-5
 $1.00 1KG 99% 20kg Career Henan Chemical Co

2-Amino-3-cyanothiophene Spectrum

2-AMINO-3-CYANOTHIOPHENE(4651-82-5)1HNMR

4651-82-5 (2-Amino-3-cyanothiophene) Related Search:

2-Amino-3-cyano-4-methyl-5-carbmethoxy thiophene 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile 2-Amino-6-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carbonitrile 2-Amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carbonitrile 3-Thiophenecarbonitrile
Methyl 3-amino-4-cyanothiophene-2-carboxylate N1-(3-Cyano-4-methyl-2-thienyl)-2-chloroacetamide 2-Amino-6-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carbonitrile Methyl 3-amino-4-cyano-5-(dimethylamino)thiophene-2-carboxylate 2-Amino-4,7-dihydro-5H-thieno[2,3-c]pyran-3-carbonitrile
Methyl 3-amino-4-cyano-5-piperidinothiophene-2-carboxylate 2-Amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carbonitrile AKOS 93048 2-amino-4,5-dihydronaphtho[2,1-b]thiophene-1-carbonitrile TIMTEC-BB SBB009939
2-Chloro-N-(3-cyano-2-thienyl)acetamide 6-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-2-(([4-(dimethylamino)phenyl]methylene)amino)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carbonitrile N'-(6-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-3-cyano-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)-N,N-dimethyliminoformamide

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ART-CHEM-BB B014697 BUTTPARK 36\18-34 2-AMINO-3-THIOPHENECARBONITRILE AKOS B014697 AKOS 92285 AKOS BBS-00006621 TIMTEC-BB SBB005484 2-AMINIO-3-CYANOTHIOPHENE 2-Aminothiophene-3-carbonitrile 97% 2-aminothiophene-3-carbonitrile(SALTDATA: FREE) JR-8818, 2-Amino-3-cyanothiophene, 97% 3-Thiophenecarbonitrile, 2-amino- 2-Aminothiophene-3ART-CHEM-BB B014697 2-Amino-3-cyanothiophene> 2-AMINO-3-CYANOTHIOPHENE ISO 9001：2015 REACH Compound Fr16663 2-AMINOTHIOPHENE-3-CARBONITRILE 2-Amino-3-cyanothiophene 4651-82-5 C5H4N2S Heterocyclic Building Blocks Thiophenes Building Blocks Amines Thiophenes & Benzothiophenes Heterocyclic Compounds Thiophenes & Benzothiophenes Building Blocks Heterocyclic Building Blocks Thiophenes