ChemicalBook >> CAS DataBase List >>2-AMINO-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBONITRILE

2-AMINO-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBONITRILE

2-AMINO-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBONITRILE structure

CAS No.: 4651-91-6

Chemical Name:: 2-AMINO-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBONITRILE

Synonyms: AKOS 92450;AKOS B000460;AKOS BBB/010;AURORA 23331;AKOS MSC-0410;ASISCHEM N16411;AKOS BBS-00007325;ZERENEX E/4047691;BUTTPARK 58\40-71;BIO-FARMA BF000441

CBNumber:: CB3323681

Molecular Formula:: C9H10N2S

Molecular Weight:: 178.25

MDL Number:: MFCD00128278

MOL File:: 4651-91-6.mol

MSDS File:: SDS

Last updated:2026-05-28 03:32:06

Product description	Number	Pack Size	Price
2-AMINO-4,5,6,7-TETRAHYDROBENZO(B)THIOPHENE-3-CARBONITRILE Aldrich^CPR	S946494	1 unit	$197
2-AMINO-4,5,6,7-TETRAHYDROBENZO(B)THIOPHENE-3-CARBONITRILE Aldrich	S946494	50mg	$179
2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile min. 98.0 %	A3580	5G	$115
2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile min. 98.0 %	A3580	25G	$346
2-Amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carbonitrile	008050	500.00mg	$168
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2-AMINO-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBONITRILE Properties

Melting point	151-153°C
Boiling point	398.1±42.0 °C(Predicted)
Density	1.27±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
pka	0.34±0.20(Predicted)
Appearance	Yellow to brown Solid
InChI	InChI=1S/C9H10N2S/c10-5-7-6-3-1-2-4-8(6)12-9(7)11/h1-4,11H2
InChIKey	ADHVMGAFAKSNOM-UHFFFAOYSA-N
SMILES	C12CCCCC=1C(C#N)=C(N)S2
CAS DataBase Reference	4651-91-6(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Warning

Hazard statements

H301-H315-H319-H335

Precautionary statements

P261-P280a-P301+P310a-P305+P351+P338-P405-P501a

Hazard Codes

Risk Statements

20/21/22-36/37/38

Safety Statements

26-36/37/39

RIDADR

3439

HazardClass

IRRITANT

HS Code

29349990

NFPA 704

	0
2		0

2-AMINO-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBONITRILE price More Price(57)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	S946494	2-AMINO-4,5,6,7-TETRAHYDROBENZO(B)THIOPHENE-3-CARBONITRILE Aldrich^CPR	4651-91-6	1 unit	$197	2026-04-30	Buy
Sigma-Aldrich	S946494	2-AMINO-4,5,6,7-TETRAHYDROBENZO(B)THIOPHENE-3-CARBONITRILE Aldrich	4651-91-6	50mg	$179	2024-03-01	Buy
TCI Chemical	A3580	2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile min. 98.0 %	4651-91-6	5G	$115	2026-04-30	Buy
TCI Chemical	A3580	2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile min. 98.0 %	4651-91-6	25G	$346	2026-04-30	Buy
Matrix Scientific	008050	2-Amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carbonitrile	4651-91-6	500.00mg	$168	2026-05-18	Buy

Product number	Packaging	Price	Buy
S946494	1 unit	$197	Buy
S946494	50mg	$179	Buy
A3580	5G	$115	Buy
A3580	25G	$346	Buy
008050	500.00mg	$168	Buy

2-AMINO-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBONITRILE Chemical Properties,Uses,Production

Chemical Properties

White solid

Synthesis

108-94-1

109-77-3

2-AMINO-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBONITRILE

4651-91-6

GENERAL METHOD: A mixture of cyclohexanone (1 mmol), malononitrile (1 mmol), elemental sulfur (1 mmol) and BSA (20 mg) was dissolved in 1 mL of DMF. The reaction was carried out at 50 °C and 200 rpm. Upon completion of the reaction, BSA was removed by filtration to terminate the reaction. For high yield products, the reaction mixture was poured into water to precipitate the solid product, which was subsequently filtered and dried. For low yield products, the crude product was purified by rapid column chromatography on silica gel with the eluent being a mixed petroleum ether/ethyl acetate solvent. The structure of the product was confirmed by IR, 1H NMR and 13C NMR spectra.1H NMR (400 MHz) and 13C NMR (100 MHz) spectra were recorded on a Bruker Avance 400 spectrometer using CDCl3 as the solvent and TMS as the internal standard.IR spectra were obtained by a Nicolet Nexus 470 FT-IR spectrophotometer. HPLC analyses were performed using an Agilent 1100 series system equipped with an Agilent TC-C18 column (for 3a, 3c, 3e, 3g, 3i, 3k: methanol/water = 60/40 at a flow rate of 1.0 mL/min with a detection wavelength of 220 nm; for 3b, 3d, 3f, 3h, 3j, 3l: methanol/water = 60/40 at a flow rate of 1.0 mL/min). (1.0 mL/min, detection wavelength 229 nm). All solvents used for column chromatography were distilled and purified before use.2.2.1. 2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile (3a) is a yellow solid with a melting point of 140-142 °C (literature values 144-146 °C).IR (KBr): 3447, 3329, 2198 cm-1.1H NMR (400 MHz, CDCl3): δ 4.62 (broad peak, 2H), 2.53-2.46 (multiple peaks, 4H), 1.85-1.73 (multiple peaks, 4H).13C NMR (100 MHz, CDCl3): δ 159.9, 132.4, 120.7, 115.5, 88.8, 24.5, 24.1, 23.4, 22.1.

References

[1] Journal of Molecular Catalysis B: Enzymatic, 2013, vol. 95, p. 29 - 35
[2] Synlett, 2010, # 9, p. 1351 - 1354
[3] Synthetic Communications, 2010, vol. 40, # 14, p. 2067 - 2074
[4] Applied Organometallic Chemistry, 2018, vol. 32, # 5,
[5] Patent: WO2005/44008, 2005, A2. Location in patent: Page/Page column 91

2-AMINO-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBONITRILE Preparation Products And Raw materials

Raw materials

Sulfur Malononitrile Ethanol Diethylamine Cyclohexanone

Bovine albumin Cyclic octaatomic sulfur N,N-Dimethylformamide

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Preparation Products

5,6,7,8-TETRAHYDRO-1H-BENZO[4,5]THIENO[2,3-D]PYRIMIDINE-2,4-DITHIONE 2-([(E)-(4-CHLOROPHENYL)METHYLIDENE]AMINO)-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBONITRILE 2-(CHLOROMETHYL)-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDIN-4-AMINE

2-AMINO-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBONITRILE Suppliers

Global( 134)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29792	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-0519-85551759 +8613506123987	marketing1@neostarunited.com	China	8828	58
Shanxi Xuanran Import and Export Trade Co., Ltd.	+8617735180244	mike_yan@xuanranglobal.com	CHINA	4017	58
AFINE CHEMICALS LIMITED	+86-0571-85134551	sales@afinechem.com	China	15073	58
Hefei Hirisun Pharmatech Co., Ltd	+8615056975894	shawn@hirisunpharm.com	CHINA	9911	58
SUZHOU SENFEIDA CHEMICAL CO.,LTD	+86-0512-83500002 +8618662433356	3899766280@qq.com	China	26362	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Accela ChemBio Inc.	58
Wuhan Chemwish Technology Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Neostar United (Changzhou) Industrial Co., Ltd.	58
Shanxi Xuanran Import and Export Trade Co., Ltd.	58
AFINE CHEMICALS LIMITED	58
Hefei Hirisun Pharmatech Co., Ltd	58
SUZHOU SENFEIDA CHEMICAL CO.,LTD	58

View Lastest Price from 2-AMINO-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBONITRILE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-01-15	2-AMINO-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBONITRILE 4651-91-6	$5.50	1KG	98%min	1kg-100kg	Career Henan Chemical Co
	2020-01-15	2-AMINO-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBONITRILE 4651-91-6	$5.50	1KG	98%min	1kg-100kg	Career Henan Chemical Co

2-AMINO-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBONITRILE
4651-91-6
$5.50
98%min
Career Henan Chemical Co

2-AMINO-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBONITRILE
4651-91-6
$5.50
98%min
Career Henan Chemical Co

2-AMINO-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBONITRILE Spectrum

2-AMINO-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBONITRILE(4651-91-6)¹HNMR

4651-91-6(2-AMINO-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBONITRILE)Related Search:

2-AMINO-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBONITRILE 2-AMINO-6-METHYL-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBONITRILE BENZO[B]THIOPHENE-3-CARBONITRILE 3-Thiophenecarbonitrile 2-CHLORO-N-(3-CYANO-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHEN-2-YL)ACETAMIDE

2-(2-FORMYL-1H-PYRROL-1-YL)-4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBONITRILE 4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBONITRILE 2-[(2-hydroxy-3-methoxybenzylidene)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carbonitrile 2-{[2-(benzyloxy)-3,5-diiodobenzylidene]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carbonitrile TIMTEC-BB SBB009939

AURORA 9534 3-(3-CYANO-4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHEN-2-YLCARBAMOYL)-ACRYLIC ACID AKOS 90761 2-AMINO-6-TERT-BUTYL-4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBONITRILE AURORA 9670

AKOS 89936 5-[(3-CYANO-4,5,6,7-TETRAHYDRO-1-BENZOTHIEN-2-YL)AMINO]-5-OXOPENTANOIC ACID 2-([(E)-(4-CHLOROPHENYL)METHYLIDENE]AMINO)-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBONITRILE

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2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBONITRYLE 2-AMINO-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBONITRILE 2-AMINO-4,5-TETRAMETHYLENE-3-THIOPHENECARBONITRILE 1-BENZOTHIOPHENE-3-CARBONITRILE, 2-AMINO-4,5,6,7-TETRAHYDRO- AKOS MSC-0410 AKOS BBS-00007325 AKOS BBB/010 AKOS B000460 AKOS 92450 TIMTEC-BB SBB000201 OTAVA-BB BB0111860022 ZERENEX E/4047691 4,5,6,7-Tetrahydro-2-amino-1-benzothiophene-3-carbonitrile 2-amino-4,5,6,7-tetrahydrobenzothiophene-3-carbonitrile 2-azanyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carbonitrile 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carbonitrile(SALTDATA: FREE) IFLAB-BB F0016-0385 CHEMBRDG-BB 3000460 BIO-FARMA BF000441 AURORA 23331 BUTTPARK 58\40-71 ART-CHEM-BB B000460 ASISCHEM N16411 2-AMINO-3-CYANO-4,5,6,7-TETRAHYDROBENZO(B)THIOPHENE 2-AMINO-4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBONITRILE 2-Amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carbonitrile, 2-Amino-3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophene 2-AMINO-4,5,6,7-TETRAHYDRO-1-BENZO[B]THIOPHENE-3-CARBONITRILE 2-Amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carbonitrile ,97% Benzo[b]thiophene-3-carbonitrile, 2-amino-4,5,6,7-tetrahydro- 2-AMINO-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CAR 3-cyano-2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene 4651-91-6 Aromatic Nitriles