1-(4-Fluorophenyl)-2-thiourea
- CAS No.
- 459-05-2
- Chemical Name:
- 1-(4-Fluorophenyl)-2-thiourea
- Synonyms
- AURORA 23199;AKOS BBS-00000721;1-(4-FLUOROPHENYL)-2;LABOTEST-BB LT00454306;4-FLUOROPHENYLTHIOUREA;4fluorobenzenethiourea;4-Fluorophenylthiourea,99%;N-(4-FLUOROPHENYL)THIOUREA;(4-Fluorophenyl)thiourea98%;(4-Fluorophenyl)thiourea>
- CBNumber:
- CB9767669
- Molecular Formula:
- C7H7FN2S
- Molecular Weight:
- 170.21
- MDL Number:
- MFCD00041180
- MOL File:
- 459-05-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 163-167 °C(lit.) |
|---|---|
| Boiling point | 264.2±42.0 °C(Predicted) |
| Density | 1.397±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | soluble in Methanol |
| form | powder to crystal |
| pka | 13.04±0.70(Predicted) |
| color | White to Almost white |
| BRN | 2803645 |
| InChI | 1S/C7H7FN2S/c8-5-1-3-6(4-2-5)10-7(9)11/h1-4H,(H3,9,10,11) |
| InChIKey | BRWKXKNZRVALNZ-UHFFFAOYSA-N |
| SMILES | NC(=S)Nc1ccc(F)cc1 |
| CAS DataBase Reference | 459-05-2(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H319 | |||||||||
| Precautionary statements | P301+P310+P330-P305+P351+P338 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | T,Xi | |||||||||
| Risk Statements | 25-36 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | YU1400000 | |||||||||
| Hazard Note | Toxic | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29309090 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
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| Hazard Classifications | Acute Tox. 3 Oral Eye Irrit. 2 |
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| Limited Quantities | 0.5 Kg (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (1g or 1ml) and Max Outer Pack (500g or 500ml) | |||||||||
| NFPA 704 |
|
1-(4-Fluorophenyl)-2-thiourea price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 632945 | (4-Fluorophenyl)thiourea 97% | 459-05-2 | 5g | $45.3 | 2026-04-30 | Buy |
| TCI Chemical | F0836 | (4-Fluorophenyl)thiourea >97.0%(HPLC)(N) | 459-05-2 | 5g | $43 | 2026-04-30 | Buy |
| TCI Chemical | F0836 | (4-Fluorophenyl)thiourea >97.0%(HPLC)(N) | 459-05-2 | 25g | $146 | 2026-04-30 | Buy |
| Biosynth | FF53891 | N-(4-Fluorophenyl)thiourea | 459-05-2 | 50g | $900 | 2026-06-04 | Buy |
| Biosynth | FF53891 | N-(4-Fluorophenyl)thiourea | 459-05-2 | 25g | $900 | 2026-06-04 | Buy |
1-(4-Fluorophenyl)-2-thiourea Chemical Properties, Uses, Production
Synthesis
1-(4-fluorophenyl)-2-thiourea can be prepared in a one-step reaction using ammonium thiocyanate and 4-fluoroaniline as starting materials. The reaction formula is shown in the figure below:
Figure 1: Reaction formula for the preparation of 1-(4-fluorophenyl)-2-thiourea
In a 50 mL reaction flask equipped with an electromagnetic stirrer, ammonium thiocyanate, 4-fluoroaniline dichloromethane, and PEG-400 were added. The mixture was stirred at room temperature for 1 hour, and then 10 mL of water was added to dissolve the inorganic salts in the reaction mixture. The precipitate was collected by filtration, dried, and recrystallized from it using a mixed solvent of N,N-dimethylformamide, ethanol, and water to give the product 1-(4-fluorophenyl)-2-thiourea.
Chemical Properties
white to off-white crystalline powder
Synthesis Reference(s)
Synthesis, p. 456, 1988 DOI: 10.1055/s-1988-27605
1-(4-Fluorophenyl)-2-thiourea Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
View Latest Price from 1-(4-Fluorophenyl)-2-thiourea manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 1-(4-FLUOROPHENYL)-2-THIOUREA
459-05-2
|
$1.00 | 1KG | 99% | Career Henan Chemical Co |
-
- 1-(4-FLUOROPHENYL)-2-THIOUREA
459-05-2
- $1.00
- 99%
- Career Henan Chemical Co
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