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PDK4-IN-1 hydrochloride

PDK4-IN-1 hydrochloride Structure
PDK4-IN-1 hydrochloride structure
CAS No.
2310262-11-2
Chemical Name:
PDK4-IN-1 hydrochloride
Synonyms
PDK4-IN-1 HCl;PDK4-IN-1 hydrochloride;PDK4-IN-1 hydrochloride, 10 mM in DMSO;1-(1-(Piperidin-4-yl)-1H-pyrazol-4-yl)anthracene-9,10-dione hydrochloride;inhibit,anti-allergic,Pyruvate dehydrogenase kinase,PDHE1α,antidiabetic,p53,BCL-xL,PARP1,caspase-3,BAX,Inhibitor,p-Akt,Apoptosis,PDK4,PDK4 IN 1 hydrochloride,PDK4IN1 hydrochloride,PDK-4-IN-1 hydrochloride,PDHK,metabolites,PDH kinase,anticancer
CBNumber:
CB98044775
Molecular Formula:
C22H20ClN3O2
Molecular Weight:
393.87
MDL Number:
MFCD32671322
MOL File:
2310262-11-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-22 15:57:46
Product description Number Pack Size Price
Pdk4-in-1 hydrochloride KSD26211 10mg $806.9
Pdk4-in-1 hydrochloride KSD26211 25mg $1316
Pdk4-in-1 hydrochloride KSD26211 50mg $2105
PDK4-IN-1 hydrochloride 99.72% CS-0116441 5mg $213
PDK4-IN-1 hydrochloride 99.72% CS-0116441 10mg $316
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PDK4-IN-1 hydrochloride Properties

storage temp. Inert atmosphere,Room Temperature
solubility DMSO: 125 mg/mL (317.36 mM)
form Solid
color Light yellow to yellow
Water Solubility H2O: 2mg/mL, clear (Warmed)
InChIKey ZIMLKZKPNALXKK-UHFFFAOYSA-N
SMILES Cl.[n]2(ncc(c2)c3c4c(ccc3)C(=O)c5c(cccc5)C4=O)C1CCNCC1
UNSPSC Code 12352200
NACRES NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
WGK Germany  WGK 3
Storage Class 11 - Combustible Solids

PDK4-IN-1 hydrochloride price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth KSD26211 Pdk4-in-1 hydrochloride 2310262-11-2 10mg $806.9 2026-06-04 Buy
Biosynth KSD26211 Pdk4-in-1 hydrochloride 2310262-11-2 25mg $1316 2026-06-04 Buy
Biosynth KSD26211 Pdk4-in-1 hydrochloride 2310262-11-2 50mg $2105 2026-06-04 Buy
ChemScene CS-0116441 PDK4-IN-1 hydrochloride 99.72% 2310262-11-2 5mg $213 2026-06-04 Buy
ChemScene CS-0116441 PDK4-IN-1 hydrochloride 99.72% 2310262-11-2 10mg $316 2026-06-04 Buy
Product number Packaging Price Buy
KSD26211 10mg $806.9 Buy
KSD26211 25mg $1316 Buy
KSD26211 50mg $2105 Buy
CS-0116441 5mg $213 Buy
CS-0116441 10mg $316 Buy

PDK4-IN-1 hydrochloride Chemical Properties,Uses,Production

Uses

PDK4-IN-1 hydrochloride is an anthraquinone derivative and a potent and orally active pyruvate dehydrogenase kinase 4 (PDK4) inhibitor with an IC50 value of 84 nM. PDK4-IN-1 hydrochloride potently represses cellular transformation and cellular proliferation and induces apoptosis. PDK4-IN-1 hydrochloride has antidiabetic, anticancer and anti-allergic activity[1].

Biological Activity

PDK4-IN-1 hydrochloride is an anthraquinone derivative and a potent, orally active inhibitor of pyruvate dehydrogenase kinase 4 (PDK4) with IC50 of 84 nM. It effectively inhibits cell transformation and cell proliferation and induces apoptosis. It has antidiabetic, anticancer and antiallergic effects.

in vitro

PDK4-IN-1 (Compound 8c; 50 μM; 0-72 hours; HCT116 and RKO cells) treatment significantly impedes the proliferation of human colon cancer cell lines, HCT116 and RKO. The colony formation efficiency in HCT116 and RKO cells Is significantly reduced after treatment of PDK4-IN-1.
PDK4-IN-1 (Compound 8c; 10-50 μM; 24 hours; HCT116 and RKO cells) treatment dose-dependently increased apoptosis.
PDK4-IN-1 (Compound 8c; 10 μM; 24 hours; HEK293T cells) treatment inhibits phosphorylation of Ser 232 , Ser 293 , and Ser 300 of PDHE1α.
10 μM of PDK4-IN-1 (Compound 8c) significantly increased p-Akt in AML12 cells.
PDK4-IN-1 (compound 8c)-induced phosphorylation of p53 on serine 15 is a dose-dependent response in both HCT116 and RKO cells. PDK4-IN-1 decreases the expression of BCL-xL and increases the expression of BAX. Cleavage of PARP1 and caspase 3 are increased by PDK4-IN-1.

Cell Viability Assay

td>
Cell Line: HCT116 and RKO cells
Concentration: 50 μM
Incubation Time: 0 hour, 24 hours, 48 hours, 72hours
Result: Significantly impeded the proliferation of human colon cancer cell lines, HCT116 and RKO.

Apoptosis Analysis

< td class="col2"> 24 hours
Cell Line: HCT116 and RKO cells
Concentration: 10 μM, 25 μM, 50 μM
Incubation Time:
Result: Dose-depend ently increased apoptosis.

Western Blot Analysis < /p>

Cell Line: HEK293T human embryonic kidney cells
Concentration: 10 μM
Incubation Time: < /td> 24 hours
Result: Inhibited phosphorylation of Ser 232 , Ser 293 , and Ser 300 of PDHE1α.

in vivo

PDK4-IN-1 (Compound 8c; 100 mg/kg; oral administration; daily; for 1 week; C57BL/6J mice) treatment significantly improves glucose tolerance.
Pre-incubation with it (compound 8c) dose-dependently inhibits the release of β-hexosaminidase from IgE/antigen-activated BMMCs, showing that the absorbance values are 0.26, 0.20, and 0.126 in IgE/Ag, 10 μM, and 20 μM PDK4- IN-1-treated BMMCs.
The pharmacokinetic (PK) profiles of PDK4-IN-1 (compound 8c) are evaluated in rat. PDK4-IN-1 shows good bioavailability (64%), long half-life ( >7 h), and moderate clearance (CL of 0.69) in rats.

td>
Animal Model: C57BL/6J mice (8 -week old) fed with high-fat diet
Dosage: 100 mg/kg
Administration: Oral adminis tration; daily; for 1 week
Result: Significantly improved glucose tolerance.

target

IC50: 84 nM (Pyruvate dehydrogenase kinase 4 (PDK4))

References

[1] Lee D, et al. Discovery of Novel Pyruvate Dehydrogenase Kinase 4 Inhibitors for Potential Oral Treatment of Metabolic Diseases. J Med Chem. 2019 Jan 24;62(2):575-588. DOI:10.1021/acs.jmedchem.8b01168

PDK4-IN-1 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

PDK4-IN-1 hydrochloride Suppliers

Global( 38)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 38999 58
Shaanxi Dideu New Materials Co. Ltd 		18192503167 1036@dideu.com China 13339 58
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 9920 65
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Shanghai Beckham Medical Technology Co., Ltd 13816613772 huahero21@sina.com China 2997 55
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Shanghai Rechem science Co., Ltd. 021-31433387 15618786686 sales@rechemscience.com China 2972 58
MQ (shanghai) Pharmaceuticals Co., Ltd. 13761635123 sales@linyuepharm.com China 5731 55
Changzhou Chenhong Biotechnology Co., Ltd. +86-0519-85788828 +86-13775037613 sales@chemrenpharm.com China 4058 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 		58
Shaanxi Dideu New Materials Co. Ltd 		58
BOC Sciences 65
Bide Pharmatech Ltd. 60
Shanghai Beckham Medical Technology Co., Ltd 55
Shanghai YuanYe Biotechnology Co., Ltd. 60
Shanghai Rechem science Co., Ltd. 58
MQ (shanghai) Pharmaceuticals Co., Ltd. 55
Changzhou Chenhong Biotechnology Co., Ltd. 58

View Lastest Price from PDK4-IN-1 hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
PDK4-IN-1 hydrochloride pictures 2026-07-22 PDK4-IN-1 hydrochloride
2310262-11-2
 1KG 98% 1000kg Shaanxi Dideu New Materials Co. Ltd
PDK4-IN-1 hydrochloride pictures 2026-07-15 PDK4-IN-1 hydrochloride
2310262-11-2
 $67.00-238.00 99.67% 10g TargetMol Chemicals Inc.
PDK4-IN-1 hydrochloride pictures 2026-07-15 PDK4-IN-1 hydrochloride
2310262-11-2
 $67.00-238.00 99.67% 10g TargetMol Chemicals Inc.

PDK4-IN-1 hydrochloride Spectrum

PDK4-IN-1 hydrochloride(2310262-11-2)1HNMR

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PDK4-IN-1 hydrochloride 1-(1-(Piperidin-4-yl)-1H-pyrazol-4-yl)anthracene-9,10-dione hydrochloride inhibit,anti-allergic,Pyruvate dehydrogenase kinase,PDHE1α,antidiabetic,p53,BCL-xL,PARP1,caspase-3,BAX,Inhibitor,p-Akt,Apoptosis,PDK4,PDK4 IN 1 hydrochloride,PDK4IN1 hydrochloride,PDK-4-IN-1 hydrochloride,PDHK,metabolites,PDH kinase,anticancer PDK4-IN-1 hydrochloride, 10 mM in DMSO PDK4-IN-1 HCl 2310262-11-2