Elgemtumab
- CAS No.
- 1512559-37-3
- Chemical Name:
- Elgemtumab
- Synonyms
- Elgemtumab;Elgemtumab (anti-ERBB3);Research Grade Elgemtumab;Research Grade Elgemtumab (DHD48401)
- CBNumber:
- CB98080926
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
- MSDS File:
- SDS
- TDS File:
- TDS
| form | Liquid |
|---|---|
| color | Colorless to light yellow |
| FDA UNII | 5F1CN52GFM |
Elgemtumab price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0635625 | Elgemtumab 99.00% | 1512559-37-3 | 1mg | $379 | 2026-06-04 | Buy |
| ChemScene | CS-0635625 | Elgemtumab 99.00% | 1512559-37-3 | 5mg | $986 | 2026-06-04 | Buy |
| ChemScene | CS-0635625 | Elgemtumab 99.00% | 1512559-37-3 | 10mg | $1571 | 2026-06-04 | Buy |
| aablocks | AA02AOJJ | Elgemtumab ≥95%(SDS-PAGE&SEC-HPLC) | 1512559-37-3 | 1mg | $572 | 2026-06-02 | Buy |
| aablocks | AA02AOJJ | Elgemtumab ≥95%(SDS-PAGE&SEC-HPLC) | 1512559-37-3 | 5mg | $1500 | 2026-06-02 | Buy |
Elgemtumab Chemical Properties, Uses, Production
Uses
Elgemtumab(LJM716) is a fully human IgG monoclonal antibody. Elgemtumab can specifically bind to HER3, block ligand-dependent and independent HER3 signal transduction and cell proliferation, and has good anti-tumor potential[1].
in vivo
Elgemtumab(LJM716)(i.v., 20 mg/kg,once) can reduce pHER3 by 52% and pAKT by 84% in SCID mice with BT474 breast cancer xenografts; while in BxPC-3 pancreatic xenografts In SCID mice, it resulted in a maximum inhibition of pHER3 of 86% and a maximum inhibition of pAKT of 74%[1].
Elgemtumab (LJM716) (20 mg/kg, every other day, 35 days) slows tumor growth in NSG mice with BT474 breast cancer xenografts[1].
References
[1] Andrew P Garner, et al. An antibody that locks HER3 in the inactive conformation inhibits tumor growth driven by HER2 or neuregulin. Cancer Res. 2013 Oct 1;73(19):6024-35. DOI:10.1158/0008-5472.CAN-13-1198
Elgemtumab Preparation Products And Raw materials
Raw materials
Preparation Products
Elgemtumab Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Guangzhou Hongyuan Chemical Co.,Ltd | 15817493340 | 981810490@qq.com | China | 1577 | 58 |
| Wuhan Chemstan Biotechnology Co., Ltd. | 027-65317797 15926423062 | 422450190@qq.com | China | 10305 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 |
| Biolab Reagents | 027-65279366 18108604356 | products@biolabreagent.com | China | 9864 | 58 |
| Wuhan Jingkangen Biomedical Technology Co., Ltd | 13720134139 086-15871494362 13720134139 | orders@jknbiochem.com | China | 7283 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Wuhan Acumen Bio-Technology Co.,ltd | 027-027-16602739303 16602739303 | 673003916@qq.com | China | 4593 | 58 |
| Changsha Fuzhen Biotechnology Co.，LTD | 15111215862 18229892877 | 3062105966@qq.com | China | 5568 | 58 |
