Tariquidar dihydrochloride
- CAS No.
- 1992047-62-7
- Chemical Name:
- Tariquidar dihydrochloride
- Synonyms
- Tariquidar dihydrochloride
- CBNumber:
- CB98202863
- Molecular Formula:
- C38H39ClN4O6
- Molecular Weight:
- 683.2
- MDL Number:
- MFCD30290160
- MOL File:
- 1992047-62-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Tariquidar dihydrochloride price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | SED04762 | Tariquidar dihydrochloride | 1992047-62-7 | 50mg | $1016 | 2026-06-05 | Buy |
| Biosynth | SED04762 | Tariquidar dihydrochloride | 1992047-62-7 | 100mg | $1414 | 2026-06-05 | Buy |
| aablocks | AA01LQHB | N-(2-((4-(2-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)carbamoyl)-4,5-dimethoxyphenyl)quinoline-3-carboxamide hydrochloride ≥98% | 1992047-62-7 | 10mg | $600 | 2026-05-30 | Buy |
| aablocks | AA01LQHB | N-(2-((4-(2-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)carbamoyl)-4,5-dimethoxyphenyl)quinoline-3-carboxamide hydrochloride ≥98% | 1992047-62-7 | 50mg | $2000 | 2026-05-30 | Buy |
| DC Chemicals | DC60759 | Tariquidar dihydrochloride 98% | 1992047-62-7 | 100mg | $400 | 2026-05-24 | Buy |
Tariquidar dihydrochloride Chemical Properties, Uses, Production
Uses
Tariquidar dihydrochloride (XR9576 dihydrochloride) is a potent and specific inhibitor of P-glycoprotein (P-gp) with the high affinity (Kd=5.1 nM)[1].
in vivo
In mice bearing the intrinsically resistant MC26 colon tumors, coadministration of Tariquidar (XR9576) potentiates the antitumor activity of Doxorubicin without a significant increase in toxicity; maximum potentiation is observed at 2.5-4.0 mg/kg dosed either i.v. or p.o. In addition, coadministration of Tariquidar (6-12 mg/kg p.o.) fully restores the antitumor activity of Paclitaxel, Etoposide, and Vincristine against two highly resistant MDR human tumor xenografts (2780AD, H69/LX4) in nude mice. Tariquidar is found to also significantly potentiate the antitumor activity of doxorubicin against s.c. MC26 tumors in vivo[2].
storage
Store at -20°C
References
[1] Martin C, et al. The molecular interaction of the high affinity reversal agent XR9576 with P-glycoprotein. Br J Pharmacol, 1999, 128(2), 403-411. DOI:10.1038/sj.bjp.0702807
[2] Mistry P, et al. In vitro and in vivo reversal of P-glycoprotein-mediated multidrug resistance by a novel potent modulator, XR9576. Cancer Res, 2001, 61(2), 749-758. PMID:11212278
Tariquidar dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Tariquidar dihydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai Rechem science Co., Ltd. | 021-31433387 15618786686 | sales@rechemscience.com | China | 2968 | 58 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9711 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| Shanghai Dongyang Biotechnology Co., Ltd. | 0512-13601744364 13601744364 | chemsharker@126.com | China | 1161 | 58 |
| Hubei wei shi reagent group ltd., company | 027-59102966 18717199209 | 2853877583@qq.com | China | 2896 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Suzhou Zhixin Biotechnology Co., Ltd. | 0512-65118909 18100677375 | sales@szzxbio.com | China | 1129 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5985 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 50068 | 58 |
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