(E)-3-[[[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-[[(3-dimethylamino)-3-oxopropyl]thio]methyl]thio]-propanoic acid, sodium salt
![(E)-3-[[[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-[[(3-dimethylamino)-3-oxopropyl]thio]methyl]thio]-propanoic acid, sodium salt Structure](CAS/GIF/115104-28-4.gif)
- CAS No.
- 115104-28-4
- Chemical Name:
- (E)-3-[[[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-[[(3-dimethylamino)-3-oxopropyl]thio]methyl]thio]-propanoic acid, sodium salt
- Synonyms
- MK-571;CS-2183;Mk 0571;Mk 0679;L-660711;MK-571 NA;MK-571, NA SALT;UNII:76LB1G2X6V;MK-571 (L660711);MK-571 SODIUM SALT
- CBNumber:
- CB1491027
- Molecular Formula:
- C26H27ClN2O3S2
- Molecular Weight:
- 515.09
- MDL Number:
- MFCD00797675
- MOL File:
- 115104-28-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
(E)-3-[[[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-[[(3-dimethylamino)-3-oxopropyl]thio]methyl]thio]-propanoic acid, sodium salt Properties
| Melting point | 65-70°C |
|---|---|
| Boiling point | 712.3±60.0 °C(Predicted) |
| Density | 1.327±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO (up to 50 mg/ml). |
| pka | 4.27±0.10(Predicted) |
| form | Off-white solid. |
| color | Yellow |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. |
| InChIKey | AXUZQJFHDNNPFG-UXBLZVDNSA-N |
| SMILES | S(C(SCCC(=O)O)c1cc(ccc1)\C=C\c2nc3c(cc2)ccc(c3)Cl)CCC(=O)N(C)C |
| FDA UNII | 76LB1G2X6V |
| UNSPSC Code | 12352211 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501 | |||||||||
| WGK Germany | WGK 1 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
(E)-3-[[[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-[[(3-dimethylamino)-3-oxopropyl]thio]methyl]thio]-propanoic acid, sodium salt price More Price(55)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 475874-M | MK571, Sodium Salt A selective, competitive antagonist of leukotriene D4 (LTD4) (Ki = 2.1 nM for inhibition of [³H]LTD4 binding to human lung membranes). | 115104-28-4 | 5 mg | $163 | 2026-04-30 | Buy |
| Sigma-Aldrich | 475874-M | MK571, Sodium Salt A selective, competitive antagonist of leukotriene D4 (LTD4) (Ki = 2.1 nM for inhibition of [³H]LTD4 binding to human lung membranes). | 115104-28-4 | 1 unit | $152 | 2025-07-31 | Buy |
| Cayman Chemical | 10029 | MK-571 ≥95% | 115104-28-4 | 1mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 10029 | MK-571 ≥95% | 115104-28-4 | 5mg | $77 | 2026-04-30 | Buy |
| Cayman Chemical | 10029 | MK-571 ≥95% | 115104-28-4 | 10mg | $132 | 2026-04-30 | Buy |
(E)-3-[[[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-[[(3-dimethylamino)-3-oxopropyl]thio]methyl]thio]-propanoic acid, sodium salt Chemical Properties, Uses, Production
Description
MK-571 is a selective, orally active CysLT1 receptor antagonist. It blocks the binding of LTD4, but not LTC4, to human and guinea pig lung membranes with Ki values of 0.22 nM and 2.1 nM, respectively, which is indicative of CysLT1 receptor-
Chemical Properties
Yellow Solid
Uses
A receptor antagonist for the treatment of respiratory diseases. Cysteinyl leukotriene receptor antagonist MK-571 alters bronchoalveolar lavage fluid proteome in asthma.
Definition
ChEBI: MK 571 is a member of quinolines.
Biological Activity
Potent CysLT 1 (LTD 4 ) leukotriene receptor inverse agonist (EC 50 = 1.3 nM). Antagonizes LTD 4 -induced contractions of guinea pig trachea and ileum (pA 2 values are 9.4 and 10.5 respectively). Also inhibitor of multidrug resistance protein-1 (MRP1) mediated transport; in vitro augments the effects of cytotoxic agents on malignant cells.
storage
Store at -20°C
References
[1] T R JONES. Pharmacology of L-660,711 (MK-571): a novel potent and selective leukotriene D4 receptor antagonist.[J]. Canadian journal of physiology and pharmacology, 1989, 67 1: 17-28. DOI:10.1139/y89-004
[2] DENIS J DUPRÉ. Inverse agonist activity of selected ligands of the cysteinyl-leukotriene receptor 1.[J]. Journal of Pharmacology and Experimental Therapeutics, 2004, 309 1: 102-108. DOI:10.1124/jpet.103.059824
[3] E VELLENGA. Interleukin-6 production by activated human monocytic cells is enhanced by MK-571, a specific inhibitor of the multi-drug resistance protein-1.[J]. British Journal of Pharmacology, 1999, 127 2: 441-448. DOI:10.1038/sj.bjp.0702577
(E)-3-[[[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-[[(3-dimethylamino)-3-oxopropyl]thio]methyl]thio]-propanoic acid, sodium salt Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| UHN Shanghai Research & Development Co., Ltd. | 021-58958002 18930822973 | sales@uhnshanghai.com | China | 997 | 58 |
| Shanghai Tauto Biotech Co., Ltd. | 021-51320588 | tauto@tautobiotech.com | China | 3984 | 66 |
| TargetMol Chemicals Inc. | 021-021-33632979 15002134094 | marketing@targetmol.com | China | 7993 | 58 |
| AdooQ Bioscience CHINA | 025-58849295 | info@adooq.cn | China | 2981 | 60 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
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(E)-3-[[[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-[[(3-dimethylamino)-3-oxopropyl]thio]methyl]thio]-propanoic acid, sodium salt Spectrum
115104-28-4 ((E)-3-[[[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-[[(3-dimethylamino)-3-oxopropyl]thio]methyl]thio]-propanoic acid, sodium salt) Related Search:
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