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ChemicalBook >> CAS DataBase List >>2-Pyrimidinamine, N-[5-[4-(dimethylamino)-1-piperidinyl]-2-pyridinyl]-5-fluoro-4-[4-methyl-2-(methylamino)-5-thiazolyl]-

2-Pyrimidinamine, N-[5-[4-(dimethylamino)-1-piperidinyl]-2-pyridinyl]-5-fluoro-4-[4-methyl-2-(methylamino)-5-thiazolyl]-

2-Pyrimidinamine, N-[5-[4-(dimethylamino)-1-piperidinyl]-2-pyridinyl]-5-fluoro-4-[4-methyl-2-(methylamino)-5-thiazolyl]- Structure
2-Pyrimidinamine, N-[5-[4-(dimethylamino)-1-piperidinyl]-2-pyridinyl]-5-fluoro-4-[4-methyl-2-(methylamino)-5-thiazolyl]- structure
CAS No.
2078047-99-9
Chemical Name:
2-Pyrimidinamine, N-[5-[4-(dimethylamino)-1-piperidinyl]-2-pyridinyl]-5-fluoro-4-[4-methyl-2-(methylamino)-5-thiazolyl]-
Synonyms
CDDD2-94;CDK4/6-IN-15;Butylated hydroxytoluene-d 21;5-(2-((5-(4(dimethylamino)piperidin-1-yl)pyridin-2-yl)amino)-5-fluoropyrimidin-4-yl)-N,4- dimethylthiazol-2-amine;2-Pyrimidinamine, N-[5-[4-(dimethylamino)-1-piperidinyl]-2-pyridinyl]-5-fluoro-4-[4-methyl-2-(methylamino)-5-thiazolyl]-
CBNumber:
CB98246207
Molecular Formula:
C21H27FN8S
Molecular Weight:
442.56
MDL Number:
MOL File:
2078047-99-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
Request For Quotation

2-Pyrimidinamine, N-[5-[4-(dimethylamino)-1-piperidinyl]-2-pyridinyl]-5-fluoro-4-[4-methyl-2-(methylamino)-5-thiazolyl]- Properties

Boiling point 641.3±65.0 °C(Predicted)
Density 1.33±0.1 g/cm3(Predicted)
pka 9.16±0.20(Predicted)
form Solid
color Light yellow to yellow

2-Pyrimidinamine, N-[5-[4-(dimethylamino)-1-piperidinyl]-2-pyridinyl]-5-fluoro-4-[4-methyl-2-(methylamino)-5-thiazolyl]- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0373974 CDK4/6-IN-15 99.32% 2078047-99-9 5mg $325 2026-06-04 Buy
ChemScene CS-0373974 CDK4/6-IN-15 99.32% 2078047-99-9 10mg $520 2026-06-04 Buy
ChemScene CS-0373974 CDK4/6-IN-15 99.32% 2078047-99-9 25mg $1029 2026-06-04 Buy
ChemScene CS-0373974 CDK4/6-IN-15 99.32% 2078047-99-9 50mg $1625 2026-06-04 Buy
ChemScene CS-0373974 CDK4/6-IN-15 99.32% 2078047-99-9 100mg $2600 2026-06-04 Buy
Product number Packaging Price Buy
CS-0373974 5mg $325 Buy
CS-0373974 10mg $520 Buy
CS-0373974 25mg $1029 Buy
CS-0373974 50mg $1625 Buy
CS-0373974 100mg $2600 Buy

2-Pyrimidinamine, N-[5-[4-(dimethylamino)-1-piperidinyl]-2-pyridinyl]-5-fluoro-4-[4-methyl-2-(methylamino)-5-thiazolyl]- Chemical Properties, Uses, Production

Uses

CDK4/6-IN-15 is an orally active and selective CDK4/6 inhibitor. CDK4/6-IN-15 potently inhibits cancer cells growth. CDK4/6-IN-15 arrests cell cycle at G1 phase and suppresses retinoblastoma tumour suppressor protein (Rb) phosphorylation at S780 and E2 factor (E2F)-regulated gene expression[1].

in vivo

CDK4/6-IN-15 (compound 91) (2 mg/kg for i.v. or 10 mg/kg for p.o.; single dose) shows comparable oral absorption in healthy male adult BALB/c mice (20-25 g) as well as (5 mg/kg for i.v. or 200 mg/kg for p.o.; single dose) in male albino Wistar rats (250-350 g)[1].


Pharmacokinetic Analysis[1]

RouteDose (mg/kg)CL (mL/min/kg)Vss (L/kg)AUC (μM·h)Cmax (μM)Tmax (h)t1/2 (h)F (%)
ratIV515527.51.21.4/2.1/
PO20//4.40.34.320.395
mouseIV29015.70.71.3/2.9/
PO10//4.30.62.52.7129

IC 50

CDK4: 3 nM (IC50); CDK6: 0.279 μM (IC50); CDK2: 3.335 μM (IC50)

References

[1] Tadesse S, et al. Discovery and pharmacological characterization of a novel series of highly selective inhibitors of cyclin-dependent kinases 4 and 6 as anticancer agents. Br J Pharmacol. 2018 Jun;175(12):2399-2413. DOI:10.1111/bph.13974

2-Pyrimidinamine, N-[5-[4-(dimethylamino)-1-piperidinyl]-2-pyridinyl]-5-fluoro-4-[4-methyl-2-(methylamino)-5-thiazolyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

2-Pyrimidinamine, N-[5-[4-(dimethylamino)-1-piperidinyl]-2-pyridinyl]-5-fluoro-4-[4-methyl-2-(methylamino)-5-thiazolyl]- Suppliers

Global Suppliers ( 5)
Supplier Tel Email Country ProdList Advantage
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 sales@chemhifuture.com China 5985 58
Suzhou Haiben Pharmaceutical Co., Ltd 19353112242 1816280386@qq.com China 8041 58
Shandong Dayou Pharmaceutical Research and Development Co., Ltd. hanfangpharma@126.com 15165037910 hanfangpharma@126.com China 25800 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
TargetMol Chemicals Inc. 13564774135 marketing@targetmol.com United States 19950 58
Supplier Advantage
Nantong QuanYi Biotechnology Co., Ltd 58
Suzhou Haiben Pharmaceutical Co., Ltd 58
Shandong Dayou Pharmaceutical Research and Development Co., Ltd. 58
TargetMol Chemicals Inc. 58
TargetMol Chemicals Inc. 58

View Latest Price from 2-Pyrimidinamine, N-[5-[4-(dimethylamino)-1-piperidinyl]-2-pyridinyl]-5-fluoro-4-[4-methyl-2-(methylamino)-5-thiazolyl]- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
CDK4/6-IN-15 pictures 2026-07-27 CDK4/6-IN-15
2078047-99-9
 $2420.00-4300.00 10g TargetMol Chemicals Inc.
  • CDK4/6-IN-15 pictures
  • CDK4/6-IN-15
    2078047-99-9
  • $2420.00-4300.00
  • TargetMol Chemicals Inc.

2078047-99-9 (2-Pyrimidinamine, N-[5-[4-(dimethylamino)-1-piperidinyl]-2-pyridinyl]-5-fluoro-4-[4-methyl-2-(methylamino)-5-thiazolyl]-) Related Search:

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2-Pyrimidinamine, N-[5-[4-(dimethylamino)-1-piperidinyl]-2-pyridinyl]-5-fluoro-4-[4-methyl-2-(methylamino)-5-thiazolyl]- 5-(2-((5-(4(dimethylamino)piperidin-1-yl)pyridin-2-yl)amino)-5-fluoropyrimidin-4-yl)-N,4- dimethylthiazol-2-amine CDDD2-94 CDK4/6-IN-15 Butylated hydroxytoluene-d 21 2078047-99-9 C21H27FN8S