Methanone, [2-amino-4-[3-(trifluoromethyl)phenyl]-3-thienyl]phenyl-
![Methanone, [2-amino-4-[3-(trifluoromethyl)phenyl]-3-thienyl]phenyl- Structure](CAS/20210305/GIF/1018830-99-3.gif)
- CAS No.
- 1018830-99-3
- Chemical Name:
- Methanone, [2-amino-4-[3-(trifluoromethyl)phenyl]-3-thienyl]phenyl-
- Synonyms
- VPC171;VCP171;VPC171, 10 mM in DMSO;Methanone, [2-amino-4-[3-(trifluoromethyl)phenyl]-3-thienyl]phenyl-;(2-Amino-4-(3-(trifluoromethyl)phenyl)thiophen-3-yl)(phenyl)methanone;(2-Amino-4-(3-(trifluoromethyl)phenyl)thiophen-3-yl)(phenyl)methanone , VCP171;VCP171,Lamina II,AMPAR,Sprague-Dawley rats,Adenosine Receptor,P1 receptor,neuropathic pain,VCP-171,VPC171,inhibit,Inhibitor,A1R,VCP 171,neurons
- CBNumber:
- CB98379004
- Molecular Formula:
- C18H12F3NOS
- Molecular Weight:
- 347.35
- MDL Number:
- MFCD34601853
- MOL File:
- 1018830-99-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 507.0±50.0 °C(Predicted) |
|---|---|
| Density | 1.345±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:6): 0.14 mg/ml,Ethanol: 10 mg/ml |
| form | A crystalline solid |
| pka | -1.73±0.14(Predicted) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
Methanone, [2-amino-4-[3-(trifluoromethyl)phenyl]-3-thienyl]phenyl- price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 30309 | VCP171 ≥98% | 1018830-99-3 | 1mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 30309 | VCP171 ≥98% | 1018830-99-3 | 5mg | $153 | 2026-04-30 | Buy |
| Cayman Chemical | 30309 | VCP171 ≥98% | 1018830-99-3 | 10mg | $219 | 2026-04-30 | Buy |
| Cayman Chemical | 30309 | VCP171 ≥98% | 1018830-99-3 | 25mg | $502 | 2026-04-30 | Buy |
| ChemScene | CS-0062698 | VCP171 99.18% | 1018830-99-3 | 1mg | $73 | 2026-06-04 | Buy |
Methanone, [2-amino-4-[3-(trifluoromethyl)phenyl]-3-thienyl]phenyl- Chemical Properties, Uses, Production
Uses
VCP171 is a potent adenosine A1 receptor (A1R) positive allosteric modulator (PAM). VCP171 is effective at decreasing excitatory synaptic currents in Lamina II of neuropathic pain model. VCP171 can be used for researching neuropathic pain[1].
Biological Activity
VCP171 is a positive allosteric modulator of adenosine A1 receptors (EC50 = 15.8 μM in a kinetic assay measuring agonist dissociation).1. It reduces AMPA receptor-mediated evoked excitatory postsynaptic currents (eEPSCs) in lamina I and lamina II neurons in a rat model of neuropathic pain (EC50s = 1.995 and 0.251 μM, respectively) to a greater extent than in sham control animals (EC50s = 2.512 and 0.631 μM, respectively).2
in vivo
VCP171 (10 μM) reduces AMPAR-mediated evoked excitatory postsynaptic current (eEPSCs) in lamina I cells in sham and nerve-injured animals; increases paired pulse ration in cells from sham control animals; is significantly more effective in Lamina II neurons from nerve-injured animals than sham controls[1].
| Animal Model: | Neurons from male Sprague-Dawley rats (5-6 weeks; performed a partial nerve ligation (PNL) of the left sciatic nerve to create neuropathic pain model)[1] |
| Dosage: | 10 μM |
| Administration: | 0-30 min |
| Result: | Reduced AMPAR-mediated evoked excitatory postsynaptic current (eEPSCs) in Lamina I cells in sham (13±2%, n=7 cells) and nerve-injured animals (24±4%, n=8 cells) compared with predrug controls; increased paired pulse ration in cells from sham control animals; was significantly more effective in Lamina II neurons from nerve-injured animals than sham controls. |
IC 50
A1R
storage
Store at -20°C
References
1.Aurelio, L., Figler, H., Flynn, B.L., et al.5-Substituted 2-aminothiophenes as A1 adenosine receptor allosteric enhancersBioorg. Med. Chem.16(3)1319-1327(2008) 2.Imlach, W.L., Bhola, R.F., May, L.T., et al.A positive allosteric modulator of the adenosine A1 receptor selectively inhibits primary afferent synaptic transmission in a neuropathic pain modelMol. Pharm.88(3)460-468(2015)
Methanone, [2-amino-4-[3-(trifluoromethyl)phenyl]-3-thienyl]phenyl- Preparation Products And Raw materials
Raw materials
Preparation Products
Methanone, [2-amino-4-[3-(trifluoromethyl)phenyl]-3-thienyl]phenyl- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| MQ (shanghai) Pharmaceuticals Co., Ltd. | 13761635123 | sales@linyuepharm.com | China | 5731 | 55 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 59929 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Henan Alpha Chemical Co., Ltd. | 0371-55013243 15324716602 | 2232176231@qq.com | China | 9996 | 58 |
| Shanghai Tengjun Biotechnology Co. LTD | 19821570922 | angela@labgogo.com | China | 9889 | 58 |
| Beijing Boorsen Biotechnology Co., Ltd | 400-901-9800 18611424007 | cis@bioss.com.cn | China | 9185 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 11975 | 58 |
