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2-Butenamide, N-[3-cyano-7-ethoxy-4-[(3-ethynylphenyl)amino]-6-quinolinyl]-4-(dimethylamino)-, (2E)-

2-Butenamide, N-[3-cyano-7-ethoxy-4-[(3-ethynylphenyl)amino]-6-quinolinyl]-4-(dimethylamino)-, (2E)- Structure
2-Butenamide, N-[3-cyano-7-ethoxy-4-[(3-ethynylphenyl)amino]-6-quinolinyl]-4-(dimethylamino)-, (2E)- structure
CAS No.
1259519-20-4
Chemical Name:
2-Butenamide, N-[3-cyano-7-ethoxy-4-[(3-ethynylphenyl)amino]-6-quinolinyl]-4-(dimethylamino)-, (2E)-
Synonyms
Sutetinib;(E)-N-(3-cyano-7-ethoxy-4-((3-ethynylphenyl)amino)quinolin-6-yl)-4-(dimethylamino)but-2-enamide;2-Butenamide, N-[3-cyano-7-ethoxy-4-[(3-ethynylphenyl)amino]-6-quinolinyl]-4-(dimethylamino)-, (2E)-
CBNumber:
CB98387669
Molecular Formula:
C26H25N5O2
Molecular Weight:
439.51
MDL Number:
MOL File:
1259519-20-4.mol
MSDS File:
SDS
Last updated:2025-04-18 09:53:10
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2-Butenamide, N-[3-cyano-7-ethoxy-4-[(3-ethynylphenyl)amino]-6-quinolinyl]-4-(dimethylamino)-, (2E)- Properties

Boiling point 665.8±55.0 °C(Predicted)
Density 1.25±0.1 g/cm3(Predicted)
pka 12.37±0.43(Predicted)
FDA UNII 538A7S75AB

2-Butenamide, N-[3-cyano-7-ethoxy-4-[(3-ethynylphenyl)amino]-6-quinolinyl]-4-(dimethylamino)-, (2E)- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-1180784 Sutetinib 99.27% 1259519-20-4 5mg $271 2026-06-04 Buy
ChemScene CS-1180784 Sutetinib 99.27% 1259519-20-4 10mg $433 2026-06-04 Buy
ChemScene CS-1180784 Sutetinib 99.27% 1259519-20-4 25mg $877 2026-06-04 Buy
ChemScene CS-1180784 Sutetinib 99.27% 1259519-20-4 50mg $1408 2026-06-04 Buy
aablocks AA02F8NW SUTETINIB >98% 1259519-20-4 5mg $313 2026-06-03 Buy
Product number Packaging Price Buy
CS-1180784 5mg $271 Buy
CS-1180784 10mg $433 Buy
CS-1180784 25mg $877 Buy
CS-1180784 50mg $1408 Buy
AA02F8NW 5mg $313 Buy

2-Butenamide, N-[3-cyano-7-ethoxy-4-[(3-ethynylphenyl)amino]-6-quinolinyl]-4-(dimethylamino)-, (2E)- Chemical Properties, Uses, Production

Uses

Sutetinib is an orally active inhibitor for tyrosine kinase, that is associated with tumor growth and angiogenesis, such as VEGFR (Ki= 0.009 μM for VEGFR-1/2/3), PDGFR (Ki= 0.008 μM for PDGFR-α/β) and proto-oncogene cKIT. Sutetinib inhibits the proliferation, migration, and tubular structure formation of endothelial cells and fibroblasts, and exhibits board-spectrum antitumor efficacy in vitro and in vivo[1].

References

[1] Hao Z, et al., Sunitinib: the antiangiogenic effects and beyond. Onco Targets Ther. 2016 Sep 8;9:5495-505. DOI:10.2147/OTT.S112242

2-Butenamide, N-[3-cyano-7-ethoxy-4-[(3-ethynylphenyl)amino]-6-quinolinyl]-4-(dimethylamino)-, (2E)- Preparation Products And Raw materials

Raw materials

Preparation Products

2-Butenamide, N-[3-cyano-7-ethoxy-4-[(3-ethynylphenyl)amino]-6-quinolinyl]-4-(dimethylamino)-, (2E)- Suppliers

Global Suppliers ( 4)
Supplier Tel Email Country ProdList Advantage
Shanghai Beckham Medical Technology Co., Ltd 13816613772 huahero21@sina.com China 2994 55
ChengDu TongChuangYuan Pharmaceutical Co.Ltd 028-83379370 13880556291 tcy@tcypharm.com China 8696 58
Suzhou Sino Rare Chemical Co., Ltd. 512-62857507 sales@sinorarechem.com China 1864 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
Supplier Advantage
Shanghai Beckham Medical Technology Co., Ltd 55
ChengDu TongChuangYuan Pharmaceutical Co.Ltd 58
Suzhou Sino Rare Chemical Co., Ltd. 58
TargetMol Chemicals Inc. 58

1259519-20-4 (2-Butenamide, N-[3-cyano-7-ethoxy-4-[(3-ethynylphenyl)amino]-6-quinolinyl]-4-(dimethylamino)-, (2E)-) Related Search:

EGFR Protein, HUMAN (621A.A, HEK293, FC) EGFR protein, HUMAN (BIOTINYLATED, HEK293, HIS-AVI) HER2/CD340 protein, HUMAN (BIOTINYLATED, HEK293, HIS) AZD-9291 Protein Tyrosine Kinase Compound Library
VEGFR-1 protein, HUMAN (BIOTINYLATED, HEK293, HIS-AVI)

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2-Butenamide, N-[3-cyano-7-ethoxy-4-[(3-ethynylphenyl)amino]-6-quinolinyl]-4-(dimethylamino)-, (2E)- Sutetinib (E)-N-(3-cyano-7-ethoxy-4-((3-ethynylphenyl)amino)quinolin-6-yl)-4-(dimethylamino)but-2-enamide 1259519-20-4