2-Butenamide, N-[3-cyano-7-ethoxy-4-[(3-ethynylphenyl)amino]-6-quinolinyl]-4-(dimethylamino)-, (2E)-

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2-Butenamide, N-[3-cyano-7-ethoxy-4-[(3-ethynylphenyl)amino]-6-quinolinyl]-4-(dimethylamino)-, (2E)- Basic information
Product Name:2-Butenamide, N-[3-cyano-7-ethoxy-4-[(3-ethynylphenyl)amino]-6-quinolinyl]-4-(dimethylamino)-, (2E)-
Synonyms:2-Butenamide, N-[3-cyano-7-ethoxy-4-[(3-ethynylphenyl)amino]-6-quinolinyl]-4-(dimethylamino)-, (2E)-;Sutetinib;(E)-N-(3-cyano-7-ethoxy-4-((3-ethynylphenyl)amino)quinolin-6-yl)-4-(dimethylamino)but-2-enamide
CAS:1259519-20-4
MF:C26H25N5O2
MW:439.51
EINECS:
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Mol File:1259519-20-4.mol
2-Butenamide, N-[3-cyano-7-ethoxy-4-[(3-ethynylphenyl)amino]-6-quinolinyl]-4-(dimethylamino)-, (2E)- Structure
2-Butenamide, N-[3-cyano-7-ethoxy-4-[(3-ethynylphenyl)amino]-6-quinolinyl]-4-(dimethylamino)-, (2E)- Chemical Properties
Boiling point 665.8±55.0 °C(Predicted)
density 1.25±0.1 g/cm3(Predicted)
pka12.37±0.43(Predicted)
Safety Information
MSDS Information
2-Butenamide, N-[3-cyano-7-ethoxy-4-[(3-ethynylphenyl)amino]-6-quinolinyl]-4-(dimethylamino)-, (2E)- Usage And Synthesis
UsesSutetinib is an orally active inhibitor for tyrosine kinase, that is associated with tumor growth and angiogenesis, such as VEGFR (Ki= 0.009 μM for VEGFR-1/2/3), PDGFR (Ki= 0.008 μM for PDGFR-α/β) and proto-oncogene cKIT. Sutetinib inhibits the proliferation, migration, and tubular structure formation of endothelial cells and fibroblasts, and exhibits board-spectrum antitumor efficacy in vitro and in vivo[1].
References[1] Hao Z, et al., Sunitinib: the antiangiogenic effects and beyond. Onco Targets Ther. 2016 Sep 8;9:5495-505. DOI:10.2147/OTT.S112242
2-Butenamide, N-[3-cyano-7-ethoxy-4-[(3-ethynylphenyl)amino]-6-quinolinyl]-4-(dimethylamino)-, (2E)- Preparation Products And Raw materials
Tag:2-Butenamide, N-[3-cyano-7-ethoxy-4-[(3-ethynylphenyl)amino]-6-quinolinyl]-4-(dimethylamino)-, (2E)-(1259519-20-4) Related Product Information
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