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5-Chloro-1-methyl-1H-benzo[d][1,3]oxazine-2,4-dione

5-Chloro-1-methyl-1H-benzo[d][1,3]oxazine-2,4-dione structure

CAS No.: 40707-01-5

Chemical Name:: 5-Chloro-1-methyl-1H-benzo[d][1,3]oxazine-2,4-dione

Synonyms: LAQU-006;5-chloro-1-methyl-3,1-benzoxazine-2,4-dione;5-Chloro-1-methylbenzo[d][1,3]oxazine-2,4-dione;5-Chloro-1-methyl-1H-benzo[d][1,3]oxazine-2,4-dione;2H-3,1-Benzoxazine-2,4(1H)-dione, 5-chloro-1-Methyl-;5-chloro-1-Methyl-2H-benzo[d][1,3]oxazine-2,4(1H)-dione

CBNumber:: CB9839779

Molecular Formula:: C9H6ClNO3

Molecular Weight:: 211.6

MDL Number:: MFCD00047630

MOL File:: 40707-01-5.mol

MSDS File:: SDS

Last updated:2026-09-12 18:56:37

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5-Chloro-1-methyl-1H-benzo[d][1,3]oxazine-2,4-dione Properties

Melting point	217.9-218.2 °C
Boiling point	344.8±44.0 °C(Predicted)
Density	1.476±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	-3.48±0.20(Predicted)
Appearance	Light brown to brown Solid
InChI	InChI=1S/C9H6ClNO3/c1-11-6-4-2-3-5(10)7(6)8(12)14-9(11)13/h2-4H,1H3
InChIKey	BTNWNXWHFWYONH-UHFFFAOYSA-N
SMILES	N1(C)C2=CC=CC(Cl)=C2C(=O)OC1=O

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

5-Chloro-1-methyl-1H-benzo[d][1,3]oxazine-2,4-dione price More Price(19)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Synthonix	C50899	5-Chloro-1-methyl-1H-benzo[d][1,3]oxazine-2,4-dione 97%	40707-01-5	250mg	$18	2026-05-06	Buy
Synthonix	C50899	5-Chloro-1-methyl-1H-benzo[d][1,3]oxazine-2,4-dione 97%	40707-01-5	1g	$30	2026-05-06	Buy
Synthonix	C50899	5-Chloro-1-methyl-1H-benzo[d][1,3]oxazine-2,4-dione 97%	40707-01-5	5g	$130	2026-05-06	Buy
aablocks	AA00C6A8	5-Chloro-1-methyl-1H-benzo[d][1,3]oxazine-2,4-dione 97%	40707-01-5	250mg	$7	2026-05-28	Buy
aablocks	AA00C6A8	5-Chloro-1-methyl-1H-benzo[d][1,3]oxazine-2,4-dione 97%	40707-01-5	1g	$17	2026-05-28	Buy

Product number	Packaging	Price	Buy
C50899	250mg	$18	Buy
C50899	1g	$30	Buy
C50899	5g	$130	Buy
AA00C6A8	250mg	$7	Buy
AA00C6A8	1g	$17	Buy

5-Chloro-1-methyl-1H-benzo[d][1,3]oxazine-2,4-dione Chemical Properties,Uses,Production

Synthesis

20829-96-3

74-88-4

40707-01-5

General procedure for the synthesis of 5-chloro-1-methyl-1H-benzo[d][1,3]oxazine-2,4-diones from 5-chloro-1H-benzo[d][1,3]oxazine-2,4-diones and iodomethane: Iodomethane (2 mL, 4.6 mmol, 4 equiv) and N,N-diisopropylethylamine (DIPEA, 1 mL, 0.74 mol) were suspended at room temperature in N,N-dimethylacetamide (DMA, 10 mL) and stirred for 10 min. Subsequently, 5-chloroisatoic anhydride (200 mg, 1.01 mmol, 1 eq.) was added and the reaction mixture was stirred at 40 °C for 5 hours. Upon completion of the reaction, the resulting product 5-chloro-1-methyl-1H-benzo[d][1,3]oxazine-2,4-dione was collected by filtration and washed with distilled water to give the pure product (150 mg, 70% yield). The melting point of the product was 224 °C. Infrared spectra (KBr) showed characteristic absorption peaks υ1774, 1716, 1593 cm^-1. 1H NMR (DMSO-d6, 300 MHz) δ 7.78 (t, J = 8.1 Hz, 1H), 7.42 (m, 2H), 3.45 (s, 3H). Elemental analysis results: calculated values for C9H6ClNO3: C, 51.08; H, 2.86; Cl, 16.75; N, 6.62; O, 22.68. measured values: C, 51.12; H, 2.36; Cl, 16.71; N, 6.58.

References

[1] Organic Process Research and Development, 2007, vol. 11, # 4, p. 674 - 680
[2] Journal of Heterocyclic Chemistry, 2016, vol. 53, # 2, p. 437 - 440
[3] European Journal of Medicinal Chemistry, 2011, vol. 46, # 1, p. 1 - 10
[4] Monatshefte fur Chemie, 2016, vol. 147, # 6, p. 1069 - 1079
[5] Journal of Medicinal Chemistry, 2004, vol. 47, # 8, p. 2075 - 2088

5-Chloro-1-methyl-1H-benzo[d][1,3]oxazine-2,4-dione synthesis

Synthesis of 5-Chloro-1-methyl-1H-benzo[d][1,3]oxazine-2,4-dione from 5-Chloro-3,1-benzoxazin-2,4-dione and Iodomethane

5-Chloro-1-methyl-1H-benzo[d][1,3]oxazine-2,4-dione Preparation Products And Raw materials

Raw materials

5-Chloro-3,1-benzoxazin-2,4-dione Iodomethane N,N-Diisopropylethylamine N,N-Dimethylacetamide

Preparation Products

5-Chloro-1-methyl-1H-benzo[d][1,3]oxazine-2,4-dione Suppliers

Global( 47)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai ChuangYan Chemical Technology Co., Ltd.	021-11111111 11111111111	546919421@qq.com	China	3770	55
Shanghai Cuisen Pharmaceutical Technology Co., Ltd.	13472757003	yongnan.wang@cendrix.cn	China	971	65
Nanjing Norris-Pharm Technology Co., Ltd	13901585132	sales@norris-pharm.com	China	8869	55
Haoyuan Chemexpress Co., Ltd.	021-58950125	info@chemexpress.com	China	7545	61
ShangHai D&B Biological Science and Technology Co.Ltd	400-008-9730,021-54359730 400-008-9730	info@chemxyz.com	China	3642	60
Porse Fine Chemical Co.,LTD	20-66003216 18666003216	info@porsefinechemical.com	China	1964	62
Shanghai Balmxy Pharmaceutical Co., Ltd	021-24206007 13764915196	sales@balmxy.com	China	6959	55
ShangHai Angti Biotechnology Co., Ltd.	13764913901	info@angtibio.com	China	4975	55
Zhengzhou Acme Chemical Co., Ltd.	0371-0371-55629727 13323845623	2885676761@qq.com	China	9948	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131885	58

Supplier	Advantage
Shanghai ChuangYan Chemical Technology Co., Ltd.	55
Shanghai Cuisen Pharmaceutical Technology Co., Ltd.	65
Nanjing Norris-Pharm Technology Co., Ltd	55
Haoyuan Chemexpress Co., Ltd.	61
ShangHai D&B Biological Science and Technology Co.Ltd	60
Porse Fine Chemical Co.,LTD	62
Shanghai Balmxy Pharmaceutical Co., Ltd	55
ShangHai Angti Biotechnology Co., Ltd.	55
Zhengzhou Acme Chemical Co., Ltd.	58
Amadis Chemical Company Limited	58

5-Chloro-1-methyl-1H-benzo[d][1,3]oxazine-2,4-dione Spectrum

5-CHLORO-1-METHYL-1H-BENZO[D][1,3]OXAZINE-2,4-DIONE(40707-01-5)¹HNMR

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5-CHLORO-1-METHYL-1H-BENZO[D][1,3]OXAZINE-2,4-DIONE 5-CHLORO-3,1-BENZOXAZIN-2,4-DIONE 1,4-dihydro-2H-3,1-benzoxazin-2-one

1of4

2H-3,1-Benzoxazine-2,4(1H)-dione, 5-chloro-1-Methyl- 5-chloro-1-Methyl-2H-benzo[d][1,3]oxazine-2,4(1H)-dione 5-chloro-1-methyl-3,1-benzoxazine-2,4-dione LAQU-006 5-Chloro-1-methylbenzo[d][1,3]oxazine-2,4-dione 5-Chloro-1-methyl-1H-benzo[d][1,3]oxazine-2,4-dione 40707-01-5 C9H6ClNO3