1-(4-Amino-piperidin-1-yl)-ethanone HCl
- CAS No.
- 214147-48-5
- Chemical Name:
- 1-(4-Amino-piperidin-1-yl)-ethanone HCl
- Synonyms
- 1-Acetyl-4-aminopiperidine hyd;1-Acetyl-4-aminopiperidine HCl;1-(4-AMino-1-piperidinyl)-ethanone HCl;1-Acetylpiperidin-4-amine hydrochloride;1-(4-Amino-piperidin-1-yl)-ethanone HCl;1-Acetyl-4-aminopiperidine hydrochloride;4-Amino-1-acetylpiperidine hydrochloride;1-Acetylpiperidin-4-amine dihydrochloride;1-(4-Aminopiperidin-1-yl)ethanone hydrochloride;1-Acetyl-4-aminopiperidine?hydrochloride 97%min
- CBNumber:
- CB9846337
- Molecular Formula:
- C7H15ClN2O
- Molecular Weight:
- 178.6598
- MDL Number:
- MFCD08690151
- MOL File:
- 214147-48-5.mol
- MSDS File:
- SDS
| Melting point | 231-234℃ |
|---|---|
| storage temp. | Inert atmosphere,Room Temperature |
| form | solid |
| Appearance | White to off-white Solid |
| Sensitive | Air Sensitive |
| InChI | 1S/C7H14N2O.ClH/c1-6(10)9-4-2-7(8)3-5-9;/h7H,2-5,8H2,1H3;1H |
| InChIKey | AWKOGAFRLOPNOP-UHFFFAOYSA-N |
| SMILES | Cl.CC(=O)N1CCC(N)CC1 |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 24/25-26-36/37 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29339900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
1-(4-Amino-piperidin-1-yl)-ethanone HCl price More Price(46)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 728764 | 1-Acetyl-4-aminopiperidine hydrochloride 96% | 214147-48-5 | 500mg | $66 | 2023-06-20 | Buy |
| Matrix Scientific | 198908 | 1-Acetylpiperidin-4-amine dihydrochloride | 214147-48-5 | 5.00g | $570 | 2026-05-18 | Buy |
| Matrix Scientific | 198908 | 1-Acetylpiperidin-4-amine dihydrochloride | 214147-48-5 | 10.00g | $1070 | 2026-05-18 | Buy |
| Matrix Scientific | 034755 | 1-Acetylpiperidin-4-amine hydrochloride | 214147-48-5 | 5.00g | $89 | 2026-05-18 | Buy |
| Matrix Scientific | 034755 | 1-Acetylpiperidin-4-amine hydrochloride | 214147-48-5 | 10.00g | $107 | 2026-05-18 | Buy |
1-(4-Amino-piperidin-1-yl)-ethanone HCl Chemical Properties, Uses, Production
Synthesis
283167-28-2
214147-48-5
The general procedure for the synthesis of 1-acetyl-4-aminopiperidine hydrochloride from tert-butyl (1-methylpiperidin-4-yl)carbamate was as follows: tert-butyl 1-(1-acetylpiperidin-4-yl)carbamate (7.72 g, 44.24 mmol) was dissolved in 1,4-dioxane (100 mL) and cooled to 0 °C, followed by the dropwise addition of 1.4 M HCl of 1,4- dioxane solution (12.2 mL, 48.7 mmol). Upon completion of the dropwise addition, a white precipitate was observed to be generated and the precipitate was separated by filtration. The resulting precipitate was dissolved in methanol (100 mL), 1,4- dioxane solution (12.2 mL, 48.7 mmol) of 4.0 M HCl was added and the reaction mixture was stirred for 16 hours at room temperature. After that, a 1,4-dioxane solution (6.10 mL, 24.4 mmol) of 4.0 M HCl was added and the reaction mixture was heated to 40 °C with continuous stirring for 1.5 hours. After completion of the reaction, the volatile solvent was removed by distillation under reduced pressure and the resulting white solid was dried at high temperature. 1-Acetyl-4-aminopiperidine hydrochloride (8.60 g, purity about 90%, yield >95%) was finally obtained. The structure of the product was confirmed by 1H NMR (400 MHz, d6-DMSO): δ 8.52-8.23 (m, 3H), 4.39-4.26 (m, 1H), 3.89-3.77 (m, 1H), 3.28-3.14 (m, 1H), 3.11-3.00 (m, 1H), 2.65-2.54 (m, 1H), 1.99 (s, 3H), 1.97-1.86 (m, 2H), 1.54-1.41 (m, 1H), 1.41-1.27 (m, 1H).
References
[1] Patent: WO2016/34675, 2016, A1. Location in patent: Page/Page column 68-69
[2] Patent: WO2016/34673, 2016, A1. Location in patent: Page/Page column 91
1-(4-Amino-piperidin-1-yl)-ethanone HCl Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Thermo Fisher Scientific | 800-810-5118 | cnchemical@thermofisher.com | China | 17752 | 75 |
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 150-2103-5486 18017383231 | 983544897@qq.com | China | 9336 | 55 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 22497 | 55 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29985 | 65 |
| Shanghai Run-Biotech Co., Ltd. | 021-57171705 13817537615 | sales@run-biotech.com | China | 2283 | 58 |
| Amatek Scientific Co. Ltd. | 0512-56316828 4008675858 | sales@amateksci.com | China | 9849 | 55 |
View Latest Price from 1-(4-Amino-piperidin-1-yl)-ethanone HCl manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-03 | 1-(4-AMINO-PIPERIDIN-1-YL)-ETHANONE HCL
214147-48-5
|
$9.80 | 1g | ≥99% | 100kg | Career Henan Chemical Co |
-
- 1-(4-AMINO-PIPERIDIN-1-YL)-ETHANONE HCL
214147-48-5
- $9.80
- ≥99%
- Career Henan Chemical Co
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