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2-Chlorotrityl chloride

2-Chlorotrityl chloride Structure
2-Chlorotrityl chloride structure
CAS No.
42074-68-0
Chemical Name:
2-Chlorotrityl chloride
Synonyms
2-CHLOROTRITYL CHLORIDE RESIN;CTC resin;2-CHLOROTRITYL RESIN;2CTC Resin;2-CHLOROTRITYLCHLORIDE POLYMER RESIN;(chloro(2-chlorophenyl)Methylene)dibenzene;2-CHLOROPHENYLDIPHENYLMETHYL CHLORIDE;CL-TRT(2-CL)-RESIN;2-Chlorotriphenylmethyl chloride resin;1-chloro-2-(chlorodiphenylmethyl)benzene
CBNumber:
CB9853612
Molecular Formula:
C19H14Cl2
Molecular Weight:
313.22
MDL Number:
MFCD00040399
MOL File:
42074-68-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-06-23 18:03:16
Request For Quotation

2-Chlorotrityl chloride Properties

Melting point 130-135 °C
Boiling point 421.3±40.0 °C(Predicted)
Density 1.222±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility Soluble in Chloroform, methanol and dichloromethane, insoluble in water
form Powder
color Pale yellow crystalline powder
BRN 1983914
InChI InChI=1S/C19H14Cl2/c20-18-14-8-7-13-17(18)19(21,15-9-3-1-4-10-15)16-11-5-2-6-12-16/h1-14H
InChIKey JFLSOKIMYBSASW-UHFFFAOYSA-N
SMILES C1(Cl)=CC=CC=C1C(Cl)(C1=CC=CC=C1)C1=CC=CC=C1
CAS DataBase Reference 42074-68-0(CAS DataBase Reference)
FDA UNII GG3RF829XL
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Exclamation Mark (GHS07)
GHS05,GHS07
Signal word  Warning
Hazard statements  H290-H315-H319-H335
Precautionary statements  P234-P261-P264-P271-P302+P352-P305+P351+P338
target organs Respiratory system
PPE Eyeshields, Gloves, type N95 (US)
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-24/25-22
RIDADR  3261
WGK Germany  3
F  10-21
HS Code  2903 99 80
HazardClass  8
PackingGroup  III
Storage Class 8A - Combustible corrosive hazardous materials
Hazard Classifications Eye Irrit. 2
Met. Corr. 1
Skin Irrit. 2
STOT SE 3
REACH Registrations Active
NFPA 704
1
0 0

2-Chlorotrityl chloride price More Price(108)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.51061 2-Chlorotrityl chloride Novabiochem? 42074-68-0 25g $206 2026-04-30 Buy
Sigma-Aldrich 26569 2-Chlorotrityl chloride ≥97.0% (AT) 42074-68-0 10g $293 2026-04-30 Buy
TCI Chemical D2504 2-Chlorotrityl Chloride >98.0%(HPLC) 42074-68-0 25g $133 2026-04-30 Buy
Usbiological 268958 2-Chlorotrityl chloride resin Asreported 42074-68-0 10g $349 2026-06-03 Buy
Usbiological 268958 2-Chlorotrityl chloride resin Asreported 42074-68-0 25g $482 2026-06-03 Buy
Product number Packaging Price Buy
8.51061 25g $206 Buy
26569 10g $293 Buy
D2504 25g $133 Buy
268958 10g $349 Buy
268958 25g $482 Buy

2-Chlorotrityl chloride Chemical Properties,Uses,Production

Chemical Properties

off-white to yellow or brown beads

Uses

2-Chlorotrityl chloride is used as an intermediate of clotrimazole. It is also used in the preparation of modified trityl nucleosides as inhibitors of P. falciparum dUTPase. In addition, it serves as a protecting group reagent for carboxylic acids forming esters.

Application

2-Chlorotrityl Chloride is used in convergent peptide synthesis. Extremely acid labile resin for preparing peptide acids and partially protected peptide fragments by the Fmoc strategy. Cleavage can be effected by using AcOH/TFE/DCM or 0.5% TFA.

Preparation

2-Chlorotrityl chloride synthesis: It is esterified with 2-Chlorobenzoic acid and ethanol in the presence of sulfuric acid or p-toluenesulfonic acid to generate Ethyl 2-Chlorobenzoate, which is then condensed with phenylmagnesium bromide (Grignard reaction) to obtain (2-Chlorophenyl)diphenylmethanol magnesium salt is hydrolyzed with sulfuric acid to obtain (2-Chlorophenyl)diphenylmethanol, which is then chlorinated with thionyl chloride to obtain the product.

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Biotechnological Applications

The 2-chlorotrityl chloride (2-CTC) resin is one of the most frequently used and most versatile resins for the large-scale manufacture of peptides. It is slightly less acid-labile than Trityl Resin and thus more widely used in solid phase peptide synthesis. Peptides UBI-8 and UBI-9 were synthesized by Fmoc-solid phase chemistry using a 2-chlorotrityl chloride linker-resin. Trityl linkers have certain advantages in comparison to the alkoxybenzyl alcohol (eg. Wang resin), especially in the area of peptide chemistry. First, the problem of racemization during the loading of the first amino acid (using DIPEA) is avoided with trityl linkers. Second, due to steric factors, no diketopiperazine formation is observed.

2-Chlorotrityl chloride synthesis

610-96-8
42074-68-0
Synthesis of 2-Chlorotrityl chloride from Methyl 2-chlorobenzoate

2-Chlorotrityl chloride Preparation Products And Raw materials

Raw materials

Ethyl 2-Chlorobenzoate Bromobenzene 2-Chlorobenzoic acid Para toluene Magnesium methoxide
Benzhydrol Thionyl chloride Clotrimazole imp. A (pharmeuropa): (2-chlorophenyl)diphenylmethanol Methyl 2-chlorobenzoate 2-Chlorobenzotrichloride

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Preparation Products

Clotrimazole

2-Chlorotrityl chloride Suppliers

Global( 395)Suppliers
Supplier Tel Email Country ProdList Advantage
Sichuan Hainuowei Technology Co. Ltd. 13708085536 13708085536 hanovichem@163.com China 3268 56
Tianjin Nuohan Chemical Co., Ltd. 16622132757 18722690935 zhuxuchen2016@yeah.net China 108 58
Shanghai QianJin Chemical Technology Co., Ltd 021-20900665 17321230821 2986274987@qq.com China 754 55
Shandong fen Boyu Biotechnology Co.,LTD 13356310019 13356310019; boyu2024@163.com China 3948 58
Jiaoda Rising Weinan Chemical Technology Co.,Ltd. 13992360862 718510010@qq.com China 30 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Supplier Advantage
Sichuan Hainuowei Technology Co. Ltd. 56
Tianjin Nuohan Chemical Co., Ltd. 58
Shanghai QianJin Chemical Technology Co., Ltd 55
Shandong fen Boyu Biotechnology Co.,LTD 58
Jiaoda Rising Weinan Chemical Technology Co.,Ltd. 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61

Related articles

View Lastest Price from 2-Chlorotrityl chloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Chlorotrityl chloride pictures 2026-09-11 2-Chlorotrityl chloride
42074-68-0
 $800.00-990.00 1ton 99% 5000 HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
2-Chlorotrityl chloride pictures 2026-09-02 2-Chlorotrityl chloride
42074-68-0
 $1.00-100.00 1KG 99% Henan Fengda Chemical Co., Ltd
2-CHLOROTRITYL CHLORIDE pictures 2026-08-21 2-CHLOROTRITYL CHLORIDE
42074-68-0
 $1200.00-1300.00 1kg 99% 300tons Hebei Dangtong Import and export Co LTD

2-Chlorotrityl chloride Spectrum

2-Chlorotrityl chloride(42074-68-0)1HNMR

42074-68-0(2-Chlorotrityl chloride)Related Search:

Tris(2,4-pentanedionato)chroMiuM(III) SALCOMINE Benzyl isocyanide Cupric acetylacetonate Aluminum acetylacetonate
COBALT(II) ACETYLACETONATE Tosylmethyl isocyanide Ethyl isocyanoacetate N-Butylisocyanide Methyl isocyanoacetate
1,1,3,3-Tetramethylbutyl isocyanide tert-Butyl isocyanide Phenylselenol Ferric acetylacetonate 2,4-Pentanedione, silver derivative
Dichloro(ethylenediamine)platinum(II) Tris(2,2,6,6-tetramethyl-3,5-heptanedionato)dysprosium(III) Tris(2,2,6,6-tetramethyl-3,5-heptanedionato)europium(III)

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Diphenyl-2-chlorophenylMethyl Chloride o-ChlorotriphenylchloroMethane Chloro(2-chlorophenyl)diphenylmethane (2-Chlorophenyl)diphenylmethyl Chloride ClotriMazole IMpurity C 2-Chlorotrityl chloride on polystyrene, 1% cross-linked, 1.0 to 1.4 mmol/g KNORR-TRT(2-CL)-RESIN KNORR-2-CHLOROTRITYL RESIN KNORR 2-CT RESIN CHLORO-2-CHLOROPHENYLDIPHENYLMETHANE CHLORO(2-CHLOROPHENYL)PHENYLMETHYL POLYSTYRENE RESIN CL-TRT(2-CL) CL-TRT(2-CL)-RESIN DIPHENYL-O-CHLOROPHENYLCHLOROMETHANE H-KNORR-2-CHLOROTRITYL RESIN BARLOS (2-CHLOROTRITYL CHLORIDE) RESIN BARLOS RESIN AMINO-2,4-DIMETHOXY-4'-(CARBOXYMETHYLOXY)BENZHYDRYLAMINE HANDLE LINKED TO 2-CHLOROTRITYL RESIN RINK AMIDE 2-CHLOROTRITYL RESIN RINK-BERNATOWITZ-AMIDE BARLOS RESIN RINK AMIDE BARLOS RESIN PL CL-TRT-CL RESIN NH2-SAL-TRT(2-CL)-RESIN O-CHLOROTRITYL CHLORIDE O-CHLORPHENYL-DIPHENYL-CHLOROMETHANE TRT(2-CL)-CL Chloro-(o-chlorophenyl)diphenylmethane 1-chloro-2-(chlorodiphenylmethyl)benzene Diphenyl(2-Chlorophenyl)Chloromethane O-CHLORPHENYL-DIPHENYL-CHLOROMETHANE(CLOTRIMAZOLE INTERMEDIATE ) 100-200mesh,1%DVB,1.0-1.6mmol/g] 2-Chlorotritylchlorideresine BARLOS-resine BR-1060 2-CHLOROPHENYL DIPHENYL CHLOROMETHANE Benzene,1-chloro-2-(chlorodiphenylMethyl)- 2-Chlorotrityl Chloride, 95.0%(T) 2-Chlorotrityl chloride, polymer-bound 200-400 mesh, extent of labeling: 1.0-1.5 mmol/g Cl loading, 1 % cross-linked 2-Chlorotrityl chloride resin(1.0-1.2 meq/g, 200-400 mesh) 2-Chlorotrityl chloride resin(1.0-2.0 meq/g, 100-200 mesh) 2-Chlorotrityl chloride resin(1.0-1.8 meq/g, 100-200 mesh) 2-Chlorotrityl chloride resin(0.3-0.8 meq/g, 200-400 mesh) 2,4-DIMETHOXY-4'-(CARBOXYMETHYLOXY)-BENZHYDRYLAMINE HANDLE LINKED TO 2-CHLOROTRITYL RESIN 2,A-DICHLORO TRIPHENYL METHANE 2,ALPHA-DICHLOROBENZHYDRYL-POLYSTYRENE CROSSLINKED WITH DIVINYLBENZENE 2,ALPHA-DICHLOROBENZHYDRYLPOLYSTYRENE DIVINYLBENZENE COPOLYMER 2-CL-(TRT)-CL RESIN 2-CLTRT RESIN 2CT-CL RESIN 2CT-CL RESIN 100 2CT-CL RESIN 200 2-CHLOROTRIPHENYL CHLOROMETHANE 2-CHLOROTRIPHENYL CHLOROMETHANE RESIN 2-CHLOROTRITYL KNORR RESIN 2-CHLOROTRITYL CHLORIDE 2-CHLOROTRITYL CHLORIDE ON POLYSTYRENE RESIN 2-CHLOROTRITYL CHLORIDE, POLYMER-BOUND 2-CHLOROTRITYLCHLORIDE POLYMER RESIN 2-CHLOROTRITYLCHLORIDE PS RESIN