pyridoxal
- CAS No.
- 66-72-8
- Chemical Name:
- pyridoxal
- Synonyms
- 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde;pyridoxal;PYRIDOXALE;PYRIDOXALDEHYDE;Pyridoxal Labeled d3;Metazachlor Impurity 8(Triflumizole);3-hydroxy-2-methyl-5-methylol-isonicotinaldehyde;3-Hydroxy-5-hydroxymethyl-2-methylpyridine-4-carbaldehyde;3-Hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarbaldehyde;3-(Hydroxymethyl)-5-hydroxy-6-methylpyridine-4-carbaldehyde
- CBNumber:
- CB9917990
- Molecular Formula:
- C8H9NO3
- Molecular Weight:
- 167.16
- MDL Number:
- MFCD00464806
- MOL File:
- 66-72-8.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 3-Hydroxy-5-(hydroxymethyl)-2-methyl-pyridine-4-carbaldehyde | 202692 | 1.00g | $896 |
| 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 98% | AA00FGGF | 100mg | $77 |
| 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 98% | AA00FGGF | 250mg | $149 |
| 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 98% | AA00FGGF | 1g | $370 |
| 3-hydroxy-5-(hydroxymethyl)-2-methylpyridine-4-carbaldehyde 97% | S74596 | 250MG | $245 |
| More product size | |||
| Melting point | 165 °C |
|---|---|
| Boiling point | 412.8±40.0 °C(Predicted) |
| Density | 1.360±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | Solid |
| pka | pKa 4.20 (H2O t = 25 I = 0.1)(Approximate) |
| color | White to off-white |
| EWG's Food Scores | 1 |
| FDA UNII | 3THM379K8A |
| EPA Substance Registry System | 4-Pyridinecarboxaldehyde, 3-hydroxy-5-(hydroxymethyl)-2-methyl- (66-72-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P330-P501 |
pyridoxal price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 202692 | 3-Hydroxy-5-(hydroxymethyl)-2-methyl-pyridine-4-carbaldehyde | 66-72-8 | 1.00g | $896 | 2026-05-18 | Buy |
| aablocks | AA00FGGF | 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 98% | 66-72-8 | 100mg | $77 | 2026-05-28 | Buy |
| aablocks | AA00FGGF | 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 98% | 66-72-8 | 250mg | $149 | 2026-05-28 | Buy |
| aablocks | AA00FGGF | 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 98% | 66-72-8 | 1g | $370 | 2026-05-28 | Buy |
| ACHEMBLOCK | S74596 | 3-hydroxy-5-(hydroxymethyl)-2-methylpyridine-4-carbaldehyde 97% | 66-72-8 | 250MG | $245 | 2026-05-27 | Buy |
pyridoxal Chemical Properties,Uses,Production
Uses
Pyridoxal is a neuroprotectant. Pyridoxal is one of the main forms of vitamin B6. Pyridoxal is phosphorylated by pyridoxal kinase to pyridoxal phosphate (HY-B1744). Pyridoxal is oxidized by the liver to 4-pyridoxic acid (HY-113493) and excreted in the urine. Pyridoxal has shown promise in the study of carpal tunnel syndrome (CTS)[1][2][3].
Definition
ChEBI: A pyridinecarbaldehyde that is pyridine-5-carbaldehyde bearing methyl, hydroxy and hydroxymethyl substituents at positions 2, 3 and 4 respectively.
Enzyme inhibitor
This photosensitive aldehyde form of vitamin B6 (FW = 167.16 g/mol), systematically referred to as 3-hydroxy-5-(hydroxymethyl)-2-methyl-4- pyridinecarboxaldehyde, is the immediate precursor to the coenzyme pyridoxal 5’-phosphate (PLP) and is often a weaker competitive inhibitor of PLP binding to PLP-dependent enzymes). Pyridoxal is soluble in water (1 g/2 mL) and sensitive to heat, particularly at alkaline pH. The pKa values are 4.23 (phenol OH), 8.70 (pyridinium NH+), and 13.0. Pyridoxal has a lmax value of 252 nm at pH 7.0 (e = 8200 M–1cm–1). It is typically supplied as the hydrochloride. Target(s): O-acetylhomoserine aminocarboxypropyltransferase, or O-acetylhomoserine (thiol)-lyase; alanine racemase; aldehyde dehydrogenase; arginine decarboxylase; cystathionine b-lyase, or cystine lyase; cysteine synthase; dextransucrase; b-fructofuranosidase, or invertase; glutamate dehydrogenase; hemoglobin S polymerization; hydroxyacyl-glutathione hydrolase, or glyoxalase II; kynurenine 3- monooxygenase; lactoylglutathione lyase, or glyoxalase I; NMN nucleosidase; phosphopantothenoylcysteine decarboxylase; porphobilinogen synthase, or d-aminolevulinate dehydratase; pyridoxal kinase; pyridoxal phosphatase, weakly inhibited; starch phosphorylase; thiamin phosphatase; tyrosinase; and xanthine dehydrogenase.
IC 50
Human Endogenous Metabolite
References
[1] Vrolijk MF, et al. The vitamin B6 paradox: Supplementation with high concentrations of pyridoxine leads to decreased vitamin B6 function. Toxicol In Vitro. 2017 Oct;44:206-212. DOI:10.1016/j.tiv.2017.07.009
[2] Aufiero E, et al. Pyridoxine hydrochloride treatment of carpal tunnel syndrome: a review. Nutr Rev. 2004 Mar;62(3):96-104. DOI:10.1111/j.1753-4887.2004.tb00030.x
[3] Nagata, Yoshiko, Reiko Yoda, and Yoshikazu Matsushima. "Solvolysis of pyridoxal hydrochloride in alcohols." Chemical and pharmaceutical bulletin 41.6 (1993): 1019-1022.
[4] Vrolijk, Misha F., et al. "The vitamin B6 paradox: Supplementation with high concentrations of pyridoxine leads to decreased vitamin B6 function." Toxicology In Vitro 44 (2017): 206-212. DOI:10.1016/j.tiv.2017.07.009
pyridoxal Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569262 +86-15003564040 | 1056@dideu.com | China | 3971 | 58 |
| Alfa Chemistry | +1-5166625404; | Info@alfa-chemistry.com | United States | 20405 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39039 | 58 |
| Chemwill Asia Co.,Ltd. | 86-21-51086038 | chemwill_asia@126.com | CHINA | 23912 | 58 |
| China Langchem Inc. | 0086-21-58956006 | China | 7811 | 57 | |
| Shanghai Macklin Biochemical Co.,Ltd. | 15221275939; 15221275939 | shenlinxing@macklin.cn | China | 15781 | 55 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66028182 17714375163 | yftan@aikonchem.com | China | 16676 | 50 |
| Alta Scientific Co., Ltd. | 022-6537-8550 15522853686 | sales@altasci.com.cn | China | 4511 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 89686 | 60 |
| Shanghai Rechem science Co., Ltd. | 021-31433387 15618786686 | sales@rechemscience.com | China | 2992 | 58 |
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