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ChemicalBook >> CAS DataBase List >>[1,1'-Biphenyl]-4-carboxylic acid, 3',5'-difluoro-4'-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-2,3,4,9-tetrahydro-3-methyl-1H-pyrido[3,4-b]indol-1-yl]-

[1,1'-Biphenyl]-4-carboxylic acid, 3',5'-difluoro-4'-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-2,3,4,9-tetrahydro-3-methyl-1H-pyrido[3,4-b]indol-1-yl]-

[1,1'-Biphenyl]-4-carboxylic acid, 3',5'-difluoro-4'-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-2,3,4,9-tetrahydro-3-methyl-1H-pyrido[3,4-b]indol-1-yl]- Structure
[1,1'-Biphenyl]-4-carboxylic acid, 3',5'-difluoro-4'-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-2,3,4,9-tetrahydro-3-methyl-1H-pyrido[3,4-b]indol-1-yl]- structure
CAS No.
2235396-63-9
Chemical Name:
[1,1'-Biphenyl]-4-carboxylic acid, 3',5'-difluoro-4'-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-2,3,4,9-tetrahydro-3-methyl-1H-pyrido[3,4-b]indol-1-yl]-
Synonyms
ERα degrader-2;[1,1'-Biphenyl]-4-carboxylic acid, 3',5'-difluoro-4'-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-2,3,4,9-tetrahydro-3-methyl-1H-pyrido[3,4-b]indol-1-yl]-
CBNumber:
CB99280404
Molecular Formula:
C29H27F3N2O2
Molecular Weight:
492.53
MDL Number:
MOL File:
2235396-63-9.mol
MSDS File:
SDS
Last updated:2026-07-27 17:00:41
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[1,1'-Biphenyl]-4-carboxylic acid, 3',5'-difluoro-4'-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-2,3,4,9-tetrahydro-3-methyl-1H-pyrido[3,4-b]indol-1-yl]- Properties

Boiling point 596.0±50.0 °C(Predicted)
Density 1.275±0.06 g/cm3(Predicted)
pka 3.89±0.10(Predicted)
form Solid
color Brown to reddish brown

[1,1'-Biphenyl]-4-carboxylic acid, 3',5'-difluoro-4'-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-2,3,4,9-tetrahydro-3-methyl-1H-pyrido[3,4-b]indol-1-yl]- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0173203 ERα degrader-2 98.30% 2235396-63-9 5mg $487 2026-06-04 Buy
ChemScene CS-0173203 ERα degrader-2 98.30% 2235396-63-9 10mg $758 2026-06-04 Buy
ChemScene CS-0173203 ERα degrader-2 98.30% 2235396-63-9 25mg $1603 2026-06-04 Buy
ChemScene CS-0173203 ERα degrader-2 98.30% 2235396-63-9 50mg $2762 2026-06-04 Buy
ChemScene CS-0173203 ERα degrader-2 98.30% 2235396-63-9 100mg $4875 2026-06-04 Buy
Product number Packaging Price Buy
CS-0173203 5mg $487 Buy
CS-0173203 10mg $758 Buy
CS-0173203 25mg $1603 Buy
CS-0173203 50mg $2762 Buy
CS-0173203 100mg $4875 Buy

[1,1'-Biphenyl]-4-carboxylic acid, 3',5'-difluoro-4'-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-2,3,4,9-tetrahydro-3-methyl-1H-pyrido[3,4-b]indol-1-yl]- Chemical Properties, Uses, Production

Uses

ERα degrader-2 is a selective estrogen receptor degrader (SERD) with potent binding affinity with ERα (IC50=17.1 nM), good degradation efficacy (EC50=0.3 nM). ERα degrader-2 exhibits favorable pharmacokinetic properties and excellent agentgability, can be used for HER+ breast cancer research[1].

in vivo

ERα degrader-2 (oral administration; 2-6 mg/kg; QD; 21 days) leads to the significant tumor growth inhibition and decreases tumor volume in mice[1].ERα degrader-2 (oral gavage; 2 mg/kg; single dose) possesses better pharmacokinetic properties thanAZD9496, the plasma exposure (AUC) is 16073.7 h*ng/mL, and the half-life period is 12.1 h, the oral availability is 80.5%[1].

Animal Model:MCF-7 human breast cancer xenograft model in nude mice[1]
Dosage:2 mg/kg; 6 mg/kg
Administration:Oral administration; 2-6 mg/kg; QD; 21 days
Result:Exhibited in vivo efficacy in breast cancer xenograft model.

IC 50

ERα: 4.6 nM (IC50)

References

[1] Xiaomeng Zhang, et al. Dynamics-Based Discovery of Novel, Potent Benzoic Acid Derivatives as Orally Bioavailable Selective Estrogen Receptor Degraders for ERα+ Breast Cancer. J Med Chem DOI:10.1021/acs.jmedchem.1c00280

[1,1'-Biphenyl]-4-carboxylic acid, 3',5'-difluoro-4'-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-2,3,4,9-tetrahydro-3-methyl-1H-pyrido[3,4-b]indol-1-yl]- Preparation Products And Raw materials

Raw materials

Preparation Products

[1,1'-Biphenyl]-4-carboxylic acid, 3',5'-difluoro-4'-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-2,3,4,9-tetrahydro-3-methyl-1H-pyrido[3,4-b]indol-1-yl]- Suppliers

Global Suppliers ( 7)
Supplier Tel Email Country ProdList Advantage
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185 sales-cpd@caerulumpharma.com China 3493 58
BOC Sciences 16314854226; +8616314854226 inquiry@bocsci.com United States 19852 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11963 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
Shanghai Amole Biotechnology Co., Ltd. 13370042665 18916960931 2596183085@qq.com China 17234 58
Aladdin Scientific tp@aladdinsci.com United States 50068 58
Supplier Advantage
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
BOC Sciences 58
TargetMol Chemicals Inc. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
TargetMol Chemicals Inc. 58
Shanghai Amole Biotechnology Co., Ltd. 58
Aladdin Scientific 58

View Latest Price from [1,1'-Biphenyl]-4-carboxylic acid, 3',5'-difluoro-4'-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-2,3,4,9-tetrahydro-3-methyl-1H-pyrido[3,4-b]indol-1-yl]- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ERα degrader-2 pictures 2026-07-27 ERα degrader-2
2235396-63-9
 $199.00 99.71% 10g TargetMol Chemicals Inc.

2235396-63-9 ([1,1'-Biphenyl]-4-carboxylic acid, 3',5'-difluoro-4'-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-2,3,4,9-tetrahydro-3-methyl-1H-pyrido[3,4-b]indol-1-yl]-) Related Search:

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[1,1'-Biphenyl]-4-carboxylic acid, 3',5'-difluoro-4'-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-2,3,4,9-tetrahydro-3-methyl-1H-pyrido[3,4-b]indol-1-yl]- ERα degrader-2 2235396-63-9 C29H27F3N2O2