[1,1'-Biphenyl]-4-carboxylic acid, 3',5'-difluoro-4'-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-2,3,4,9-tetrahydro-3-methyl-1H-pyrido[3,4-b]indol-1-yl]-

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[1,1'-Biphenyl]-4-carboxylic acid, 3',5'-difluoro-4'-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-2,3,4,9-tetrahydro-3-methyl-1H-pyrido[3,4-b]indol-1-yl]- Suppliers list
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[1,1'-Biphenyl]-4-carboxylic acid, 3',5'-difluoro-4'-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-2,3,4,9-tetrahydro-3-methyl-1H-pyrido[3,4-b]indol-1-yl]- manufacturers

  • ERα degrader-2
  • ERα degrader-2 pictures
  • $199.00
  • 2026-07-27
  • CAS:2235396-63-9
  • Purity: 99.71%
  • Supply Ability: 10g
[1,1'-Biphenyl]-4-carboxylic acid, 3',5'-difluoro-4'-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-2,3,4,9-tetrahydro-3-methyl-1H-pyrido[3,4-b]indol-1-yl]- Basic information
Product Name:[1,1'-Biphenyl]-4-carboxylic acid, 3',5'-difluoro-4'-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-2,3,4,9-tetrahydro-3-methyl-1H-pyrido[3,4-b]indol-1-yl]-
Synonyms:[1,1'-Biphenyl]-4-carboxylic acid, 3',5'-difluoro-4'-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-2,3,4,9-tetrahydro-3-methyl-1H-pyrido[3,4-b]indol-1-yl]-;ERα degrader-2
CAS:2235396-63-9
MF:C29H27F3N2O2
MW:492.53
EINECS:
Product Categories:
Mol File:2235396-63-9.mol
[1,1'-Biphenyl]-4-carboxylic acid, 3',5'-difluoro-4'-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-2,3,4,9-tetrahydro-3-methyl-1H-pyrido[3,4-b]indol-1-yl]- Structure
[1,1'-Biphenyl]-4-carboxylic acid, 3',5'-difluoro-4'-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-2,3,4,9-tetrahydro-3-methyl-1H-pyrido[3,4-b]indol-1-yl]- Chemical Properties
Boiling point 596.0±50.0 °C(Predicted)
density 1.275±0.06 g/cm3(Predicted)
pka3.89±0.10(Predicted)
form Solid
color Brown to reddish brown
Safety Information
MSDS Information
[1,1'-Biphenyl]-4-carboxylic acid, 3',5'-difluoro-4'-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-2,3,4,9-tetrahydro-3-methyl-1H-pyrido[3,4-b]indol-1-yl]- Usage And Synthesis
UsesERα degrader-2 is a selective estrogen receptor degrader (SERD) with potent binding affinity with ERα (IC50=17.1 nM), good degradation efficacy (EC50=0.3 nM). ERα degrader-2 exhibits favorable pharmacokinetic properties and excellent agentgability, can be used for HER+ breast cancer research[1].
in vivo

ERα degrader-2 (oral administration; 2-6 mg/kg; QD; 21 days) leads to the significant tumor growth inhibition and decreases tumor volume in mice[1].ERα degrader-2 (oral gavage; 2 mg/kg; single dose) possesses better pharmacokinetic properties thanAZD9496, the plasma exposure (AUC) is 16073.7 h*ng/mL, and the half-life period is 12.1 h, the oral availability is 80.5%[1].

Animal Model:MCF-7 human breast cancer xenograft model in nude mice[1]
Dosage:2 mg/kg; 6 mg/kg
Administration:Oral administration; 2-6 mg/kg; QD; 21 days
Result:Exhibited in vivo efficacy in breast cancer xenograft model.
IC 50ERα: 4.6 nM (IC50)
References[1] Xiaomeng Zhang, et al. Dynamics-Based Discovery of Novel, Potent Benzoic Acid Derivatives as Orally Bioavailable Selective Estrogen Receptor Degraders for ERα+ Breast Cancer. J Med Chem DOI:10.1021/acs.jmedchem.1c00280
[1,1'-Biphenyl]-4-carboxylic acid, 3',5'-difluoro-4'-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-2,3,4,9-tetrahydro-3-methyl-1H-pyrido[3,4-b]indol-1-yl]- Preparation Products And Raw materials
Tag:[1,1'-Biphenyl]-4-carboxylic acid, 3',5'-difluoro-4'-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-2,3,4,9-tetrahydro-3-methyl-1H-pyrido[3,4-b]indol-1-yl]-(2235396-63-9) Related Product Information
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