amicarbalide
- CAS No.
- 3459-96-9
- Chemical Name:
- amicarbalide
- Synonyms
- M&B 5062 A;amicarbalide;3,3'-Diamidinocarbanilide;3,3'-Ureylenebisbenzamidine;1,3-bis(3-amidinophenyl)urea;1,3-bis(3-carbamimidoylphenyl)urea;3,3'-carbonylbis(azanediyl)dibenzimidamide;3,3'-Carbonyldiiminobis(benzenecarboxamidine);3,3'-(Carbonyldiimino)bis(benzenecarbimidamide);Benzenecarboximidamide, 3,3'-(carbonyldiimino)bis-
- CBNumber:
- CB9934450
- Molecular Formula:
- C15H16N6O
- Molecular Weight:
- 296.332
- MDL Number:
- MFCD00866999
- MOL File:
- 3459-96-9.mol
- MSDS File:
- SDS
| Density | 1.40 |
|---|---|
| pka | 13.69±0.70(Predicted) |
| FDA UNII | D7CJB20DJO |
amicarbalide Chemical Properties, Uses, Production
Originator
Diampron,May and Baker
Uses
Amicarbalide is an active compound.
Manufacturing Process
m-Aminobenzonitrile (50 g) in anhydrous pyridine (200 ml) was treated with a
solution of phosgene (15 ml) in anhydrous toluene (100 ml) over 10 min with
mechanical stirring. The red solution was heated for 0.5 hour on the steam
bath, cooled, and added to water (2 litres). The pale grey precipitate was
filtered off, washed with ether, and crystallised from methanol (250 ml). N,N1-
Di(m-cyanophenyl)urea separated as grey prisms, melting point 205-206°C.
A suspension of N,N1-di(m-cyanophenyl)urea (42 g) in anhydrous chloroform
(420 ml), containing anhydrous ethanol (70 ml), was saturated with
anhydrous hydrogen chloride at 0-5°C. After setting aside for 2 hours, a clear
solution was obtained, which began to crystallise. After a week, the crystals
were filtered off, washed well with anhydrous ether, and dried over calcium
chloride. The iminoether hydrochloride so obtained (72 g) was added to
saturated anhydrous ethanolic ammonia (720 ml), and the suspension heated
at 55-60°C for 6 hours. After cooling to 20°C the crystals were filtered off,
and recrystallized from 2 N hydrochloric add (300 ml). 3,31-
Diamidinodiphenylurea dihydrochloride monohydrate separated as white
prisms, melting point 286°C (decomp.).
In practice it is usually used as isethonate salt.
Therapeutic Function
Antiprotozoal
References
[1] Prevention by polyamines of the curative effect of amicarbalide and imidocarb for Trypanosoma brucei infections in mice.
amicarbalide Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu HuaXia Chemical Reagent Co. Ltd | 400-1166-196 13458535857 | cdhxsj@163.com | China | 13323 | 58 |
| Alfa Chemistry | 1-516-6625404 | support@alfa-chemistry.com | United States | 9170 | 60 |
| Shandong Xiya Chemical Co., Ltd. | 4009903999 13395398332 | sales@xiyashiji.com | China | 20788 | 60 |
| Shandong Ono Chemical Co., Ltd. | 0539-6362799 20） | China | 10007 | 58 | |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +86-189 4982 3763 | sales@tnjchem.com | China | 34526 | 58 |
| Chemwill Asia Co.,Ltd. | 86-21-51086038 | chemwill_asia@126.com | CHINA | 23861 | 58 |
| Hangzhou Cyanochem Co., Ltd. | +86 17788583750 | sales@cyanochem.com | CHINA | 280 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 | |
| Shanghai Bohu Biotechnology Co., LTD | 021-57763112 13585886131 | 3004987436@qq.com | China | 9688 | 58 |
View Latest Price from amicarbalide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-21 | Amicarbalide
3459-96-9
|
$1520.00-2500.00 | 10g | TargetMol Chemicals Inc. |
-
- Amicarbalide
3459-96-9
- $1520.00-2500.00
- TargetMol Chemicals Inc.
