Aliskiren
- CAS No.
- 173334-57-1
- Chemical Name:
- Aliskiren
- Synonyms
- CS-201;SPP 100;Rasilez;Tekturna;CGP60536B;CGP 60536;Aliskiren;Aliskiren Base;Aliskiren (USAN);Aliskiren, >=98%
- CBNumber:
- CB9966226
- Molecular Formula:
- C30H53N3O6
- Molecular Weight:
- 551.76
- MDL Number:
- MFCD09839018
- MOL File:
- 173334-57-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Aliskiren | CDS023114 | 10MG | $230 |
| Aliskiren 99.16% | CS-0443 | 50mg | $240 |
| 5-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide fumarate | FA134549 | 250mg | $60 |
| Aliskiren | A3153 | 1g | $314 |
| 5-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide fumarate | FA134549 | 2g | $350 |
| More product size | |||
| Melting point | 98-99 °C |
|---|---|
| Boiling point | 748.4±60.0 °C(Predicted) |
| Density | 1.067±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | DMSO : 100 mg/mL (181.24 mM; Need ultrasonic) |
| pka | 9.49(at 25℃) |
| form | Powder |
| color | White to light yellow |
| InChIKey | UXOWGYHJODZGMF-PPPRLRNRNA-N |
| SMILES | C(C)(C)(CNC(=O)[C@H](C(C)C)C[C@H](O)[C@@H](N)C[C@@H](C(C)C)CC1C=CC(OC)=C(OCCCOC)C=1)C(N)=O |&1:7,12,14,17,r| |
| CAS DataBase Reference | 173334-57-1(CAS DataBase Reference) |
| FDA UNII | 502FWN4Q32 |
| ATC code | C09XA02 |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| target organs | Respiratory system |
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
| Hazardous Substances Data | 173334-57-1(Hazardous Substances Data) |
Aliskiren price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | CDS023114 | Aliskiren | 173334-57-1 | 10MG | $230 | 2026-04-30 | Buy |
| ChemScene | CS-0443 | Aliskiren 99.16% | 173334-57-1 | 50mg | $240 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA134549 | 5-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide fumarate | 173334-57-1 | 250mg | $60 | 2021-12-16 | Buy |
| ApexBio Technology | A3153 | Aliskiren | 173334-57-1 | 1g | $314 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA134549 | 5-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide fumarate | 173334-57-1 | 2g | $350 | 2021-12-16 | Buy |
Aliskiren Chemical Properties,Uses,Production
Description
Aliskiren is a first-in-class antihypertensive drug that acts by direct inhibition of renin. It is indicated for oral administration either as monotherapy or in combination with other antihypertensive agents. Renin catalyzes the cleavage of angiotensin to form angiotensin I, the first and the rate-limiting step of the RAAS. The inhibition of renin by aliskiren results in reduced levels of angiotensin I, angiotensin II, and aldosterone, all of which contribute to the antihypertensive effect. RAAS modulators are among some of the most commonly prescribed antihypertensive agents to date.The most common side effect of aliskiren is diarrhea, particularly with doses higher than 300mg daily. Unlike ACE inhibition, direct inhibition of renin does not increase bradykinin levels. Elevated bradykinin levels are thought to be responsible for the angioderma and cough that occur commonly during treatment with ACE inhibitors. .
Originator
Novartis (Switzerland)
Uses
An orally active, synthetic nonpeptide renin inhibitor. Antihypertensive
Uses
liquid crystal intermediate
Definition
ChEBI: A monomethoxybenzene compound having a 3-methoxypropoxy group at the 2-position and a multi-substituted branched alkyl substituent at the 4-position.
brand name
Tekturna
General Description
Aliskiren, (2S,4S,5S,7S)-5-amino-N-(2-carbamoyl-2-methyl-propyl)-4-hydroxy-7-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-8-methyl-2-propan-2-yl-nonanamide (Tekturna), is the first renin inhibitorintroduced into the U. S. market. It was approved by theFDA in 2007 for the management of hypertension.The trade name for aliskiren in the United Kingdom isRasilez.
Aliskiren Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 | deasea125996@gmail.com | China | 2472 | 58 |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618092446649 | sarah@tnjone.com | China | 1143 | 58 |
| Apeloa production Co.,Limited | +8619933239880 | admin@apcl.com.cn | China | 861 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21590 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29819 | 58 |
| Casorganics US Corp | +17326109938 | sales@casorganics.com | CHINA | 174 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 | sales@amoychem.com | China | 6369 | 58 |
View Lastest Price from Aliskiren manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-04 | Aliskiren
173334-57-1
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2026-04-29 | Aliskiren
173334-57-1
|
US $67.00-107.00 / mg | 97.58% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-03-20 | Aliskiren
173334-57-1
|
US $10.00 / KG | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd |
