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6-chloro-Nmethylpyrimidin-4-amine

6-chloro-Nmethylpyrimidin-4-amine structure

CAS No.: 65766-32-7

Chemical Name:: 6-chloro-Nmethylpyrimidin-4-amine

Synonyms: EOS-60926;4-Chloro-6-methylaminopyrimidine;6-chloro-Nmethylpyrimidin-4-amine;4-Pyrimidinamine, 6-chloro-N-methyl-;4-Pyrimidinamine, 6-chloro-N-methyl- (9CI);6-chloro-Nmethylpyrimidin-4-amine ISO 9001：2015 REACH

CBNumber:: CB9970924

Molecular Formula:: C5H6ClN3

Molecular Weight:: 143.57

MDL Number:: MFCD09702146

MOL File:: 65766-32-7.mol

MSDS File:: SDS

Last updated:2026-05-28 05:27:35

Product description	Number	Pack Size	Price
4-Chloro-6-(methylamino)pyrimidine 97%	732087	1g	$74.5
6-Chloro-n-methylpyrimidin-4-amine >98%	OR322371	5g	$21
6-Chloro-n-methylpyrimidin-4-amine >98%	OR322371	25g	$54
6-Chloro-N-methylpyrimidin-4-amine 97%	AS31338	5g	$25
6-Chloro-n-methylpyrimidin-4-amine >98%	OR322371	100g	$207
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6-chloro-Nmethylpyrimidin-4-amine Properties

Melting point	138-142°C
Boiling point	279.7±20.0 °C(Predicted)
Density	1.338±0.06 g/cm3(Predicted)
storage temp.	2-8°C
pka	2.50±0.10(Predicted)
form	solid
Appearance	White to off-white Solid
InChI	InChI=1S/C5H6ClN3/c1-7-5-2-4(6)8-3-9-5/h2-3H,1H3,(H,7,8,9)
InChIKey	WZVLJUBTIWFTIE-UHFFFAOYSA-N
SMILES	C1=NC(Cl)=CC(NC)=N1
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H317-H319-H335
Precautionary statements	P280-P301+P312+P330-P302+P352-P305+P351+P338
target organs	Respiratory system
Hazard Codes	Xn
Risk Statements	22-36/37/38-43
Safety Statements	26-36/37/39
WGK Germany	3
HazardClass	IRRITANT
HS Code	2933599590
Storage Class	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 Skin Sens. 1 STOT SE 3

6-chloro-Nmethylpyrimidin-4-amine price More Price(52)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	732087	4-Chloro-6-(methylamino)pyrimidine 97%	65766-32-7	1g	$74.5	2023-06-20	Buy
Apolloscientific	OR322371	6-Chloro-n-methylpyrimidin-4-amine >98%	65766-32-7	5g	$21	2026-06-04	Buy
Apolloscientific	OR322371	6-Chloro-n-methylpyrimidin-4-amine >98%	65766-32-7	25g	$54	2026-06-04	Buy
Activate Scientific	AS31338	6-Chloro-N-methylpyrimidin-4-amine 97%	65766-32-7	5g	$25	2026-06-04	Buy
Apolloscientific	OR322371	6-Chloro-n-methylpyrimidin-4-amine >98%	65766-32-7	100g	$207	2026-06-04	Buy

Product number	Packaging	Price	Buy
732087	1g	$74.5	Buy
OR322371	5g	$21	Buy
OR322371	25g	$54	Buy
AS31338	5g	$25	Buy
OR322371	100g	$207	Buy

6-chloro-Nmethylpyrimidin-4-amine Chemical Properties,Uses,Production

Synthesis

1193-21-1

593-51-1

65766-32-7

General procedure for the synthesis of 6-chloro-N-methyl-4-aminopyrimidine from 4,6-dichloropyrimidine and methylamine hydrochloride: in a 100 mL round-bottomed flask N,N-dimethylformamide (10 mL), 4,6-dichloropyrimidine (1 g, 6.71 mmol, 1.0 equiv.), cesium carbonate (4.4 g, 13.50 mmol, 2.01 equiv.) and methylamine hydrochloride (905 mg, 13.40 mmol, 2.00 eq.). The reaction mixture was stirred at 80 °C for 14 hours. After completion of the reaction, the reaction solution was diluted with 10 mL of water and extracted with ethyl acetate (4 x 10 mL). The organic layers were combined and washed once with 10 mL of water. The organic phase was concentrated under reduced pressure and the resulting residue was purified by silica gel column chromatography with ethyl acetate/petroleum ether (1:1) as eluent. 750 mg (78% yield) of the target product 6-chloro-N-methyl-4-aminopyrimidine was finally obtained as a white solid. The product was analyzed by LC-MS to confirm: (ES, m/z): retention time RT = 0.476 min, LCMS 32: m/z = 144 [M + 1].

References

[1] European Journal of Organic Chemistry, 2014, vol. 2014, # 7, p. 1514 - 1524
[2] Patent: WO2017/181177, 2017, A1. Location in patent: Paragraph 0950-0953
[3] Tetrahedron, 2007, vol. 63, # 25, p. 5394 - 5405

6-chloro-Nmethylpyrimidin-4-amine Preparation Products And Raw materials

Raw materials

4,6-Dichloropyrimidine Methylamine Methylamine hydrochloride N,N-Dimethylformamide Cesium carbonate

Preparation Products

6-chloro-Nmethylpyrimidin-4-amine Suppliers

Global( 150)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29792	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
KARMEL TECHNOLOGY (HK) CO.,LIMITED	+8618795957998	karmelhk@126.com	CHINA	2886	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	21169	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Accela ChemBio Inc.	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
KARMEL TECHNOLOGY (HK) CO.,LIMITED	58
Dideu Industries Group Limited	58

View Lastest Price from 6-chloro-Nmethylpyrimidin-4-amine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-11-18	6-chloro-Nmethylpyrimidin-4-amine 65766-32-7	$1.10	1g	99.00%	100 Tons Min	Dideu Industries Group Limited
	2019-12-31	6-chloro-Nmethylpyrimidin-4-amine 65766-32-7	$1.00	1KG	99%	10000KGS	Career Henan Chemical Co

6-chloro-Nmethylpyrimidin-4-amine
65766-32-7
$1.10
99.00%
Dideu Industries Group Limited

6-chloro-Nmethylpyrimidin-4-amine
65766-32-7
$1.00
99%
Career Henan Chemical Co

6-chloro-Nmethylpyrimidin-4-amine Spectrum

6-chloro-Nmethylpyrimidin-4-amine(65766-32-7)MS 6-chloro-Nmethylpyrimidin-4-amine(65766-32-7)¹HNMR 6-chloro-Nmethylpyrimidin-4-amine(65766-32-7)IR1 6-chloro-Nmethylpyrimidin-4-amine(65766-32-7)IR2

65766-32-7(6-chloro-Nmethylpyrimidin-4-amine)Related Search:

WY-14643 4-CHLORO-2,6-DIPYRROLIDIN-1-YLPYRIMIDINE N1-(3-[(2,5,6-TRICHLOROPYRIMIDIN-4-YL)AMINO]PHENYL)-4-METHYLBENZAMIDE N4-benzyl-6-chloropyrimidine-4,5-diamine 4-(m-aminoanilino)-2,5,6-trichloropyrimidine

N4-METHYL-6-CHLORO-5-NITROPYRIMIDIN-4-AMINE N-PHENYL-N'-(3-[(2,5,6-TRICHLOROPYRIMIDIN-4-YL)AMINO]PHENYL)UREA N-(4-CHLOROPHENYL)-N'-(3-[(2,5,6-TRICHLOROPYRIMIDIN-4-YL)AMINO]PHENYL)UREA 7-(4-TERT-BUTYLPHENYL)-4-CHLORO-6,7-DIHYDRO-2-(METHYLTHIO)-(5H)-PYRROLO[2,3-D]PYRIMIDINE 4-CHLORO-7-(3,5-DIMETHYLPHENYL)-6,7-DIHYDRO-2-(METHYLTHIO)-(5H)-PYRROLO[2,3-D]PYRIMIDINE

4-CHLORO-7-CYCLOHEXYL-6,7-DIHYDRO-2-(METHYLTHIO)-(5H)-PYRROLO[2,3-D]PYRIMIDINE N1-(3-[(2,5,6-TRICHLOROPYRIMIDIN-4-YL)AMINO]PHENYL)-4-(TRIFLUOROMETHYL)BENZENE-1-SULFONAMIDE N1-(3-[(2,5,6-TRICHLOROPYRIMIDIN-4-YL)AMINO]PHENYL)-4-CHLOROBENZENE-1-SULFONAMIDE N1-(3-[(2,5,6-TRICHLOROPYRIMIDIN-4-YL)AMINO]PHENYL)-4-FLUOROBENZAMIDE N1-(3-[(2,5,6-TRICHLOROPYRIMIDIN-4-YL)AMINO]PHENYL)-4-METHYLBENZENE-1-SULFONAMIDE

4-CHLORO-2-METHYLSULFANYL-6-PHENYLAMINO-PYRIMIDINE-5-CARBONITRILE 4-CHLORO-6,7-DIHYDRO-7-(4-METHOXYPHENYL)-2-(METHYLTHIO)-(5H)-PYRROLO[2,3-D]PYRIMIDINE N1-(3-[(2,5,6-TRICHLOROPYRIMIDIN-4-YL)AMINO]PHENYL)-3-(TRIFLUOROMETHYL)BENZAMIDE

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6-chloro-Nmethylpyrimidin-4-amine 4-Pyrimidinamine, 6-chloro-N-methyl- (9CI) 4-Chloro-6-methylaminopyrimidine EOS-60926 4-Pyrimidinamine, 6-chloro-N-methyl- 6-chloro-Nmethylpyrimidin-4-amine ISO 9001：2015 REACH 65766-32-7 amine|alkyl chloride Amines PYRIMIDINE blocks APIs & Intermediate