4,6-Dichloropyrimidine
- CAS No.
- 1193-21-1
- Chemical Name:
- 4,6-Dichloropyrimidine
- Synonyms
- DichloropyriMidine;4,6-Dichoropyrimidine;NSC 37530;4,6-DichL;IFLAB-BB F2124-0077;4,6-Dichloropyrimidi;4,6-Dichloropyridine;4,6-Dichlorpyrimidin;4,6-Dichloropyrimidin;4,6-DICHLOROPYRIMIDINE
- CBNumber:
- CB6473590
- Molecular Formula:
- C4H2Cl2N2
- Molecular Weight:
- 148.98
- MDL Number:
- MFCD00006109
- MOL File:
- 1193-21-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 4,6-Dichloropyrimidine 97% | 145378 | 10g | $100 |
| 4,6-Dichloropyrimidine 97% | 145378 | 50g | $348 |
| 4,6-Dichloropyrimidine >98.0%(GC) | D2488 | 5g | $20 |
| 4,6-Dichloropyrimidine >98.0%(GC) | D2488 | 25g | $40 |
| 4,6-Dichloropyrimidine | D3521 | 5g | $312 |
| More product size | |||
| Melting point | 65-67 °C (lit.) |
|---|---|
| Boiling point | 176 °C (lit.) |
| Density | 1.6445 (rough estimate) |
| vapor pressure | 30-390Pa at 20-50℃ |
| refractive index | 1.6300 (estimate) |
| Flash point | 176°C |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | 95% ethanol: soluble50mg/mL, clear to very slightly hazy, colorless to yellow |
| form | Crystals |
| pka | -4.20±0.17(Predicted) |
| color | Yellow-green |
| BRN | 111195 |
| InChI | 1S/C4H2Cl2N2/c5-3-1-4(6)8-2-7-3/h1-2H |
| InChIKey | XJPZKYIHCLDXST-UHFFFAOYSA-N |
| SMILES | Clc1cc(Cl)ncn1 |
| LogP | 1.45 at 25℃ and pH7.2 |
| Surface tension | 65.72mN/m at 1g/L and 20℃ |
| CAS DataBase Reference | 1193-21-1(CAS DataBase Reference) |
| FDA UNII | TTE9SA8H44 |
| NIST Chemistry Reference | Pyrimidine, 4,6-dichloro-(1193-21-1) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314 | |||||||||
| Precautionary statements | P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 34-20/21/22-36/37 | |||||||||
| Safety Statements | 26-36/37/39-45-27 | |||||||||
| RIDADR | UN 3263 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 19 | |||||||||
| Hazard Note | Corrosive | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29335990 | |||||||||
| Storage Class | 8A - Combustible corrosive hazardous materials | |||||||||
| Hazard Classifications | Skin Corr. 1B | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
4,6-Dichloropyrimidine price More Price(92)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 145378 | 4,6-Dichloropyrimidine 97% | 1193-21-1 | 10g | $100 | 2026-04-30 | Buy |
| Sigma-Aldrich | 145378 | 4,6-Dichloropyrimidine 97% | 1193-21-1 | 50g | $348 | 2026-04-30 | Buy |
| TCI Chemical | D2488 | 4,6-Dichloropyrimidine >98.0%(GC) | 1193-21-1 | 5g | $20 | 2026-04-30 | Buy |
| TCI Chemical | D2488 | 4,6-Dichloropyrimidine >98.0%(GC) | 1193-21-1 | 25g | $40 | 2026-04-30 | Buy |
| Usbiological | D3521 | 4,6-Dichloropyrimidine | 1193-21-1 | 5g | $312 | 2026-06-03 | Buy |
4,6-Dichloropyrimidine Chemical Properties,Uses,Production
Uses
4,6-Dichloropyrimidine (cas# 1193-21-1) is a compound useful in organic synthesis.
Chemical Properties
Yellow Solid
Uses
4,6-Dichloropyrimidine was used in the synthesis of N-substituted azacalix[4]pyrimidines. It was used as starting reagent for the synthesis of disubstituted pyrimidines by tandem amination and Suzuki-Miyaura cross-coupling. It was also used in a biarylpyrimidine synthesis involving biaryl cross-coupling.
General Description
Cyclic voltammograms of 4,6-dichloropyrimidine shows three cathodic waves, arising from sequential cleavage of carbon-chlorine bonds as well as the reduction of pyrimidine.
Synthesis
The synthesis of 4,6-Dichloropyrimidine is as follows:Dissolve 105.5g of 4,6-diaminopyrimidine in 660.0g of 31% hydrochloric acid and pour into a 2000ml bottle to cool to -5 ° C and dropwise add 500.3g of 33% sodium nitrite. After 2 hours of reaction, HPLC detects 4,6-diamino Pyrimidine is less than 0.5%. 42.8 g of cuprous chloride and 214.0 g of 31% hydrochloric acid are prepared in a 2000 ml bottle. The diazonium salt mother liquor is added dropwise to the bottle. After the dropwise reaction, the reaction is performed at 45 ° C for 2 hours. .Extract with 400g of recovered trichloroethane (200x2 times less than new ones), combine the organic layers for distillation, control the water flush pump 5KPa, temperature 40-140 , collect 404.2g of solvent in the early 40-90 , 90-140 in the later The product was collected at a temperature of 14 ° C to obtain 146.9 g of 4,6-dichloropyrimidine. The yield was 86.4% (based on formazan hydrochloride) and the purity was 99.4%.
References
[1] Patent: CN108395409, 2018, A. Location in patent: Paragraph 0039-0041; 0044
[2] Patent: CN105439963, 2016, A. Location in patent: Paragraph 0011
[3] Patent: CN108341784, 2018, A. Location in patent: Paragraph 0027; 0028; 0029; 0031-0033; 0039; 0040
[4] Patent: CN105732514, 2016, A. Location in patent: Paragraph 0027; 0028
[5] Patent: CN108178749, 2018, A. Location in patent: Paragraph 0027; 0028; 0030; 0032; 0034; 0036; 0038; 0040
4,6-Dichloropyrimidine Preparation Products And Raw materials
Raw materials
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Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| EAST STAR BIOTECH (SUZHOU) CO., LTD. | +8617706846989 | marketing@eaststarbio.com | China | 48 | 58 |
| Wuhan Aoliqisi New Material Technology Co., Ltd. | +86-13545906766; +8613545906766 | sales@whaop.com | China | 263 | 58 |
| Golden Pharma Co., Limited | +undefined18958062155 | sales@zjgoldpharm.com | China | 5899 | 58 |
| Shandong Jihui Chemical Co., Ltd. | +8615053042019 | sales@jihuichem.com | China | 34 | 58 |
| Shanghai Cube Chemical Co., Ltd. | +86-02156500520 +86-18116101847 | kevin.li@cubechem.com | China | 43 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 | sales1@chuanghaibio.com | China | 5220 | 58 |
| Chongqing Soarwin Technology Co., Ltd | +86-15790943001 | crystal@sorawin.cn | China | 421 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 14026 | 58 |
View Lastest Price from 4,6-Dichloropyrimidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-28 | 4,6-Dichloropyrimidine
1193-21-1
|
1KG | 99%min | 1000KGS | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-07-16 | 4,6-Dichloropyrimidine
1193-21-1
|
1kg | 98 | 1000kgs | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-05-28 | 4,6-Dichloropyrimidine
1193-21-1
|
$9.00 | 1KG | 99.9 | 1 ton | Hebei Chuanghai Biotechnology Co,.LTD |
-
- 4,6-Dichloropyrimidine
1193-21-1
- $0.00
- 99%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 4,6-Dichloropyrimidine
1193-21-1
- $0.00
- 98
- Shaanxi Dideu New Materials Co. Ltd
-
- 4,6-Dichloropyrimidine
1193-21-1
- $9.00
- 99.9
- Hebei Chuanghai Biotechnology Co,.LTD
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