2-(4-ヒドロキシフェニル)-4-メチルチアゾール-5-カルボン酸エチル
2-(4-ヒドロキシフェニル)-4-メチルチアゾール-5-カルボン酸エチル 物理性質
- 融点 :
- 180 ºC
- 沸点 :
- 426.8±55.0 °C(Predicted)
- 比重(密度) :
- 1.274
- 貯蔵温度 :
- Sealed in dry,Room Temperature
- 溶解性:
- DMSO（微量）、メタノール（微量）
- 外見 :
- 個体
- 酸解離定数(Pka):
- 8.56±0.15(Predicted)
- 色:
- オフホワイト
- InChI:
- InChI=1S/C13H13NO3S/c1-3-17-13(16)11-8(2)14-12(18-11)9-4-6-10(15)7-5-9/h4-7,15H,3H2,1-2H3
- InChIKey:
- LOCYSKNNFCGDTR-UHFFFAOYSA-N
- SMILES:
- S1C(C(OCC)=O)=C(C)N=C1C1=CC=C(O)C=C1
- CAS データベース:
- 161797-99-5(CAS DataBase Reference)
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
2-(4-ヒドロキシフェニル)-4-メチルチアゾール-5-カルボン酸エチル 価格
もっと(8)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBST-7934 |
2-(4-ヒドロキシフェニル)-4-メチルチアゾール-5-カルボン酸エチル
Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate |
161797-99-5 |
5g |
￥10000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBST-7934 |
2-(4-ヒドロキシフェニル)-4-メチルチアゾール-5-カルボン酸エチル
Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate |
161797-99-5 |
1g |
￥10000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBST-7934 |
Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate |
161797-99-5 |
100g |
￥129600 |
2021-03-23 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBST-7934 |
2-(4-ヒドロキシフェニル)-4-メチルチアゾール-5-カルボン酸エチル
Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate |
161797-99-5 |
25g |
￥40000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01FLC025271 |
2-(4-Hydroxyphenyl)-4-methyl-thiazole-5-carboxylic acid ethyl ester |
161797-99-5 |
1g |
￥6300 |
2021-03-23 |
購入 |
2-(4-ヒドロキシフェニル)-4-メチルチアゾール-5-カルボン酸エチル 化学特性,用途語,生産方法
使用
Ethyl 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxylate is used in the synthesis of the major metabolites of Febuxostat (F229000), a xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.
合成
A mixture of 4-cyanophenol, NaOH, and ethanol was mixed in a pressure bottle while heated to 80° C. Hydrogen sulfide gas was then introduced, and the pressure increased to 30-60 psi until the thioamidation was determined to be complete by HPLC. Without isolating the thioamide product, HCl was added to the bottle until the pH was below 3.5, the H2S gas was removed, and the bottle was placed under a vacuum for 20 minutes at 30-40° C. The reaction was then heated to 70° C, and ethyl 2-chloroacetoacetate(1.1 eq.) was added to the reaction solution. The reaction was mixed under reflux for 2-3 hours, treated with enough H2O to dissolve the NaCl salt in the reaction mixture, cooled to room temperature, treated with enough water to precipitate the product, and the solid was collected by filtration. The precipitate was washed with water and dried at 80° C. with nitrogen bleeding to provide Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate.
2-(4-ヒドロキシフェニル)-4-メチルチアゾール-5-カルボン酸エチル 上流と下流の製品情報
原材料
準備製品
2-(4-ヒドロキシフェニル)-4-メチルチアゾール-5-カルボン酸エチル 生産企業
Global( 387)Suppliers
2-(4-ヒドロキシフェニル)-4-メチルチアゾール-5-カルボン酸エチル スペクトルデータ(1HNMR)
161797-99-5(2-(4-ヒドロキシフェニル)-4-メチルチアゾール-5-カルボン酸エチル)キーワード:
- 161797-99-5
- ethyl 2-(4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate
- Ethyl 2-(4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate
- 2-(4-hydroxyphenyl)-4-Methyl-5-Thiazolecarboxylicacid ethyl ester
- 5-Thiazolecarboxylic acid, 2-(4-hydroxyphenyl)-4-Methyl-, ethyl ester
- Intermediates of Febuxostat
- Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate
Ethyl 2-(4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate
- 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate
- Febuxostat Descyano Hydroxy Ethyl Ester
- 3-thiazole-5-carboxylate
- Ethyl 2-(4-hydroxyphenyl)-4-methyl-1
- 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxytic acid ethyl ester
- Febuxostat Impurity, Ethyl 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxylate (G)
- ethyl 2-(4-hydroxyphenyl)
- Febuxostat-8
- Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Ethyl 2-
- ethyl 2-(4-hydroxyphenyl)-4-methyl thiazole-5-carb
- Ethyl2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate,97%
- Febuxostat intermediates，Ethyl 2-(4-hydroxyphenyl)-4- methylthiazole-5-carboxylate
- CAS 161797-99-5 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxytic acid ethyl
- Febuxostat Desaldehyde Impurity
- ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate 2-
- ethyl 4-methyl-2-(4-oxocyclohexa-2,5-dien-1-ylidene)-3H-1,3-thiazole-5-carboxylate
- Ethyl 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxylate(G)
- Ethyl 2-(4-hydroxyphenyl)-4- ethylthiazole-5-carboxylate
- Intermediate 2 of non brucite
- Ethyl 2-(4-+B1:C32Hydroxyphenyl)-4-Methyl-5- Thiazolecarboxylate
- Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate（F2）
- Febuxostat Impurity A-1
- ethyl 2-(4-hydroxyphenyl)-4-Methyl-5-Thiazolecarboxylate
- 2-(4-ヒドロキシフェニル)-4-メチルチアゾール-5-カルボン酸エチル