Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate

Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate

Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Structure
Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate structure
CAS No.
161797-99-5
Chemical Name:
Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate
Synonyms
ethyl 2-(4-hydroxyphenyl)-4-Methyl-5-Thiazolecarboxylate;Febuxostat-8;Febuxostat Impurity A-1;3-thiazole-5-carboxylate;ethyl 2-(4-hydroxyphenyl);Intermediates of Febuxostat;Intermediate 2 of non brucite;Febuxostat Desaldehyde Impurity;Ethyl 2-(4-hydroxyphenyl)-4-methyl-1;Febuxostat Descyano Hydroxy Ethyl Ester
CBNumber:
CB02128586
Molecular Formula:
C13H13NO3S
Molecular Weight:
263.31
MDL Number:
MFCD03700424
MOL File:
161797-99-5.mol
MSDS File:
SDS
Last updated:2026-05-27 17:22:57
Request For Quotation

Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Properties

Melting point 180 ºC
Boiling point 426.8±55.0 °C(Predicted)
Density 1.274
storage temp. Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Very Slightly)
form Solid
pka 8.56±0.15(Predicted)
color Off-White
InChI InChI=1S/C13H13NO3S/c1-3-17-13(16)11-8(2)14-12(18-11)9-4-6-10(15)7-5-9/h4-7,15H,3H2,1-2H3
InChIKey LOCYSKNNFCGDTR-UHFFFAOYSA-N
SMILES S1C(C(OCC)=O)=C(C)N=C1C1=CC=C(O)C=C1
CAS DataBase Reference 161797-99-5(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
REACH Registrations Active
NFPA 704
1
2 0

Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate price More Price(58)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 448766 Ethyl 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxylate 161797-99-5 250mg $319 2026-06-03 Buy
Usbiological 448766 Ethyl 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxylate 161797-99-5 500mg $418 2026-06-03 Buy
Biosynth FE15829 Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate 161797-99-5 5g $900 2026-06-04 Buy
Biosynth FE15829 Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate 161797-99-5 50g $900 2026-06-04 Buy
Biosynth FE15829 Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate 161797-99-5 25g $900 2026-06-04 Buy
Product number Packaging Price Buy
448766 250mg $319 Buy
448766 500mg $418 Buy
FE15829 5g $900 Buy
FE15829 50g $900 Buy
FE15829 25g $900 Buy

Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Chemical Properties, Uses, Production

Uses

Ethyl 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxylate is used in the synthesis of the major metabolites of Febuxostat (F229000), a xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.

Synthesis

A mixture of 4-cyanophenol, NaOH, and ethanol was mixed in a pressure bottle while heated to 80° C. Hydrogen sulfide gas was then introduced, and the pressure increased to 30-60 psi until the thioamidation was determined to be complete by HPLC. Without isolating the thioamide product, HCl was added to the bottle until the pH was below 3.5, the H2S gas was removed, and the bottle was placed under a vacuum for 20 minutes at 30-40° C. The reaction was then heated to 70° C, and ethyl 2-chloroacetoacetate(1.1 eq.) was added to the reaction solution. The reaction was mixed under reflux for 2-3 hours, treated with enough H2O to dissolve the NaCl salt in the reaction mixture, cooled to room temperature, treated with enough water to precipitate the product, and the solid was collected by filtration. The precipitate was washed with water and dried at 80° C. with nitrogen bleeding to provide Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate. ethyl 2-(4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate

References

[1] Patent: US2005/75503, 2005, A1. Location in patent: Page/Page column 3

Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Preparation Products And Raw materials

Raw materials

4-Cyanophenol 4-Hydroxythiobenzamide Ethyl 2-chloroacetoacetate 2-(4-Methoxy-phenyl)-4-methyl-thiazole-5-carboxylicacidethylester ethyl 2-broMo-3-oxobutanoate
Hydrogen Sulfide Hydrochloric acid Sodium hydroxide

1of2

Preparation Products

Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate Ethyl 2-(3-Formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate

Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Suppliers

Global Suppliers ( 387)
Supplier Tel Email Country ProdList Advantage
SuZhou Yumed Pharmaceutical Technology Co.,Ltd 199-5111-2435 19951112435 qibuxiang@163.com China 62 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
XiaoGan ShenYuan ChemPharm co,ltd 15527621225; 15527621225 1791901229@qq.com China 6744 52
Beijing Isomersyn Technology CO;LTD 010-82954736 13391601435 sales@isomersyn.com China 3294 57
Supplier Advantage
SuZhou Yumed Pharmaceutical Technology Co.,Ltd 58
J & K SCIENTIFIC LTD. 76
Chembest Research Laboratories Limited 61
Alfa Aesar 84
Jia Xing Isenchem Co.,Ltd 66
Pure Chemistry Scientific Inc. 62
Adamas Reagent, Ltd. 59
Shanghai Hanhong Scientific Co.,Ltd. 64
XiaoGan ShenYuan ChemPharm co,ltd 52
Beijing Isomersyn Technology CO;LTD 57

View Latest Price from Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ethyl 2-(4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate pictures 2026-08-25 ethyl 2-(4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate
161797-99-5
 $70.00-700.00 10kg 0.99 20tons Zibo Hangyu Biotechnology Development Co., Ltd
Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate pictures 2026-05-22 Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate
161797-99-5
 99.99% 1000000T Anhuyan (Hainan) Biotechnology Co., LTD
Febuxostat Impurity 8 pictures 2026-03-12 Febuxostat Impurity 8
161797-99-5
 10mg 98% 500mg ShenZhen H&D Pharmaceutical Technology Co., LTD

Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Spectrum

Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate(161797-99-5)1HNMR

161797-99-5 (Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate) Related Search:

Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate 2-(4-Hydroxy-phenyl)-4-methyl-thiazole-5-carboxylic acid ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate 2-[3-(AMinocarbonyl)-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-thiazolecarboxylic Acid Febuxostat Descyano Impurity
isopropyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate FeBuxostat Impurity 18 2-[3-Carboxy-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-thiazolecarboxylic Acid Febuxostat Impurity 8 Methyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate
Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate Febuxostat Ethyl 2-(3-Cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate 3-Cyano-4-(2-methylpropoxy)benzenecarbothioamide Ethyl 2-(3-bromo-4-isobutoxyphenyl)- 4-methyl-5-thiazolecarboxylate
4-Hydroxythiobenzamide ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate 4-Methylthiazole

1of4

ethyl 2-(4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate Ethyl 2-(4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate 2-(4-hydroxyphenyl)-4-Methyl-5-Thiazolecarboxylicacid ethyl ester 5-Thiazolecarboxylic acid, 2-(4-hydroxyphenyl)-4-Methyl-, ethyl ester Intermediates of Febuxostat Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Ethyl 2-(4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Febuxostat Descyano Hydroxy Ethyl Ester 3-thiazole-5-carboxylate Ethyl 2-(4-hydroxyphenyl)-4-methyl-1 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxytic acid ethyl ester Febuxostat Impurity, Ethyl 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxylate (G) ethyl 2-(4-hydroxyphenyl) Febuxostat-8 Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Ethyl 2- ethyl 2-(4-hydroxyphenyl)-4-methyl thiazole-5-carb Ethyl2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate,97% Febuxostat intermediates，Ethyl 2-(4-hydroxyphenyl)-4- methylthiazole-5-carboxylate CAS 161797-99-5 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxytic acid ethyl Febuxostat Desaldehyde Impurity ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate 2- ethyl 4-methyl-2-(4-oxocyclohexa-2,5-dien-1-ylidene)-3H-1,3-thiazole-5-carboxylate Ethyl 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxylate(G) Ethyl 2-(4-hydroxyphenyl)-4- ethylthiazole-5-carboxylate Intermediate 2 of non brucite Ethyl 2-(4-+B1:C32Hydroxyphenyl)-4-Methyl-5- Thiazolecarboxylate Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate（F2） Febuxostat Impurity A-1 ethyl 2-(4-hydroxyphenyl)-4-Methyl-5-Thiazolecarboxylate 161797-99-5 161798-99-5 Febuxostat Intermediates Febuxostat intermediate