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GW1929 水和物

GW1929 水和物 化学構造式
196808-24-9
CAS番号.
196808-24-9
化学名:
GW1929 水和物
别名:
GW1929 水和物;(2S)-2-[(2-ベンゾイルフェニル)アミノ]-3-(4-{2-[メチル(ピリジン-2-イル)アミノ]エトキシ}フェニル)プロパン酸;N-(2-ベンゾイルフェニル)-O-[2-[メチル(2-ピリジル)アミノ]エチル]-L-チロシン;GW-1929;(S)-3-[4-[2-[メチル(2-ピリジル)アミノ]エトキシ]フェニル]-2-[(2-ベンゾイルフェニル)アミノ]プロピオン酸
英語名:
GW1929
英語别名:
L-Tyrosine, N-(2-benzoylphenyl)-O-[2-(methyl-2-pyridinylamino)ethyl]-;GW1929;GW1929 HYDRATE;GW 1929 hydrochlorid;GW 1929 hydrochloride;GW1929, 10 mM in DMSO;GW1929, PPARgamma agonist;GW1929 - CAS 196808-24-9 - Calbiochem;N-(2-BENZOYLPHENYL)-O-[2-(METHYL-2-PYRIDINYLAMINO)ETHYL]-L-TYROSINE;N-(2-Benzoylphenyl)-O-[2-(methyl-2-pyridinylamino)ethyl]-L-tyrosine hydrate
CBNumber:
CB0259985
化学式:
C30H29N3O4
分子量:
495.57
MOL File:
196808-24-9.mol
MSDS File:
SDS

GW1929 水和物 物理性質

沸点 :
749.2±60.0 °C(Predicted)
比重(密度) :
1.264±0.06 g/cm3(Predicted)
貯蔵温度 :
Desiccate at +4°C
溶解性:
DMSO: 20 mg/mL
酸解離定数(Pka):
3.91±0.10(Predicted)
外見 :
個体
色:
黄色
InChIKey:
QTQMRBZOBKYXCG-MHZLTWQESA-N
SMILES:
C(O)(=O)[C@H](CC1=CC=C(OCCN(C)C2=NC=CC=C2)C=C1)NC1=CC=CC=C1C(=O)C1=CC=CC=C1

安全性情報

WGK Germany  3
ストレージクラス 11 - Combustible Solids

GW1929 水和物 価格 もっと(2)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
Sigma-Aldrich Japan G5668 GW1929 水和物 >98% (HPLC), solid
GW1929 hydrate >98% (HPLC), solid		 196808-24-9 5mg ￥46200 2024-03-01 購入
Sigma-Aldrich Japan G5668 GW1929 水和物 >98% (HPLC), solid
GW1929 hydrate >98% (HPLC), solid		 196808-24-9 25mg ￥137000 2024-03-01 購入

GW1929 水和物 化学特性,用途語,生産方法

説明

Peroxisome proliferator-activated receptor (PPAR) γ is a nuclear receptor that, when activated, regulates fatty acid storage and glucose metabolism. The best known class of PPARγ ligands are the thiazolidinediones, including troglitazone and rosiglitazone. GW 1929 is a non-thiazolidinedione activator of PPARγ that binds with a Ki value of 1.4 nM, with greater than 1,000-fold selectivity over other PPAR subtypes. It has anti-hyperglycemic and anti-hyperlipidemic activity when given orally in mouse and rat models of type 2 diabetes. Both in vitro and in vivo effects of GW 1929 on PPARγ greatly exceed those produced by troglitazone. In addition, GW 1929 has neuroprotective effects in global cerebral ischemic-reperfusion injury that are related to reduced inflammation and apoptotic DNA fragmentation.

使用

GW1929 has been used as a peroxisome proliferator-activated receptor γ (PPARγ) ligand:
Investigating its impact on the expression of plant homeodomain finger protein 16 (Phf16) and patatin-like phospholipase domain containing 3 (Pnpla3) in relation to adipogenesis.
Examining its influence on complement component 3 (C3) gene expression in human hepatoma cells.
Activating PPARγ in human breast cancer cells.

生物活性

Highly selective orally active peroxisome proliferator-activated receptor (PPAR) γ agonist (pEC 50 values are 8.05, < 4 and < 4 for human PPAR γ , PPAR α and PPAR δ receptors respectively). Decreases glucose, fatty acid and triglyceride levels following oral administration in vivo .

参考文献

[1] heppner tj,bonev ad,eckman dm,gomez mf,petkov gv,nelson mt. novel ppargamma agonists gi 262570, gw 7845, gw 1929, and pioglitazone decrease calcium channel function and myogenic tone in rat mesenteric arteries. pharmacology.2005 jan;73(1):15-22.
[2] kaundal rk,sharma ss. ameliorative effects of gw1929, a nonthiazolidinedione pparγ agonist, on inflammation and apoptosis in focal cerebral ischemic-reperfusion injury. curr neurovasc res.2011 aug 1;8(3):236-45.
[3] GW1929: a nonthiazolidinedione PPARγ agonist, ameliorates neurological damage in global cerebral ischemic-reperfusion injury through reduction in inflammation and DNA fragmentation DOI: 10.1016/j.bbr.2010.09.001

GW1929 水和物 上流と下流の製品情報

原材料

準備製品

GW1929 水和物 生産企業

Global( 144)Suppliers
名前 電話番号 電子メール 国籍 製品カタログ 優位度
Nanjing Yiming Pharmaceutical Technology Co., Ltd. 19850700912; 19850700912
 13851286085@163.com China 979 58
Shanghai Shengxiu Biotechnology Co., Ltd. 13761144602
 3896578657@qq.com China 4644 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840
psaitong@jm-bio.com China 27626 58
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037
 3bsc@sina.com China 15813 69
NCE Biomedical Co.,Ltd. 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
China 1490 55
Haoyuan Chemexpress Co., Ltd. 021-58950125
info@chemexpress.com China 7545 61
MedChemexpress LLC 021-58955995
sales@medchemexpress.cn United States 4853 58
Shanghai Tauto Biotech Co., Ltd. 021-51320588
tauto@tautobiotech.com China 3984 66
AdooQ BioScience, LLC +1 (866) 930-6790
info@adooq.com United States 2774 58
AdooQ Bioscience CHINA 025-58849295
info@adooq.cn China 2981 60

GW1929 水和物  スペクトルデータ(1HNMR)

GW1929(196808-24-9)1HNMR

196808-24-9(GW1929 水和物)キーワード:

ヘキサフェニルエタン N-メチルホルムアミド アニソール ホルムアニリド GW1929 水和物 GW-9578
  • 196808-24-9
  • GW1929
  • GW1929 HYDRATE
  • N-(2-Benzoylphenyl)-O-[2-(methyl-2-pyridinylamino)ethyl]-L-tyrosine hydrate
  • (2S)-2-(2-benzoylanilino)-3-[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]propanoic acid
  • (S)-2-(2-Benzoylphenylamino)-3-(4-(2-(methyl(pyridin-2-yl)amino)ethoxy)phenyl)propanoic acid
  • GW 1929 hydrochloride
  • N-(2-Benzoylphenyl)-O-[2-(methyl-2-pyridinylamino)ethyl]-L-tyrosinehydrochloride
  • N-(2-BENZOYLPHENYL)-O-[2-(METHYL-2-PYRIDINYLAMINO)ETHYL]-L-TYROSINE
  • GW1929 - CAS 196808-24-9 - Calbiochem
  • GW 1929 hydrochlorid
  • (2S)-2-[(2-benzoylphenyl)amino]-3-(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}phenyl)propanoic acid
  • GW1929, PPARgamma agonist
  • GW1929, 10 mM in DMSO
  • L-Tyrosine, N-(2-benzoylphenyl)-O-[2-(methyl-2-pyridinylamino)ethyl]-
  • GW1929 水和物
  • (2S)-2-[(2-ベンゾイルフェニル)アミノ]-3-(4-{2-[メチル(ピリジン-2-イル)アミノ]エトキシ}フェニル)プロパン酸
  • N-(2-ベンゾイルフェニル)-O-[2-[メチル(2-ピリジル)アミノ]エチル]-L-チロシン
  • GW-1929
  • (S)-3-[4-[2-[メチル(2-ピリジル)アミノ]エトキシ]フェニル]-2-[(2-ベンゾイルフェニル)アミノ]プロピオン酸
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