リルメニジン 化学特性,用途語,生産方法
効能
血圧降下薬, α2アドレナリン受容体作動薬
説明
Rilmenidine is a new antihypertensive agent with a selective alphaz-agonist/antagonist
profile, reportedly useful in the management of mild to moderate hypertension. Its
fmt-line indication is possible because of the clear dissociation of its antihypertensive
activity from other neurophannacological effects.
化学的特性
water soluble
使用
I1-imidazoline binding site ligand and a2-adrenoceptor agonist, exhibits higher I1 vs. a2 selectivity than clonidine
生物活性
I 1 -imidazoline binding site selective ligand and α 2 -adrenoceptor agonist. Possesses greater I 1 vs α 2 selectivity than the prototypical compound, clonidine.
代謝経路
In short-term rat hepatocyte cultures, oxaminozoline is
metabolized and its four metabolites resulting from
oxidation or hydrolysis are identified, three of which
are identical to those reported in vivo. The presence of
an additional minor metabolite in culture may be due
to the higher metabolic rate of oxaminozoline in this
model system.
リルメニジン 上流と下流の製品情報
原材料
準備製品