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5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine

化学構造式
493028-20-9
CAS番号.
493028-20-9
化学名:
别名:
英語名:
5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine
英語别名:
CBFβInhibitor;CBFβ Inhibitor;TIMTEC-BB SBB011699;Runx1-CBFβ interaction inhibitor 1;2-Thiazolamine, 5-ethyl-4-(4-methoxyphenyl)-;CBFβ Inhibitor - CAS 493028-20-9 - Calbiochem;5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine;5-ethyl-4-(4-methoxyphenyl)-1,3-thiazol-2-amine
CBNumber:
CB0412427
化学式:
C12H14N2OS
分子量:
234.32
MOL File:
Mol file

5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine 物理性質

沸点 :
421.6±40.0 °C(Predicted)
比重(密度) :
1.192±0.06 g/cm3(Predicted)
貯蔵温度 :
+2C to +8C
溶解性:
DMF: 50 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 30 mg/ml; Ethanol: 25 mg/ml
外見 :
黄褐色の固体
酸解離定数(Pka):
5.00±0.10(Predicted)

安全性情報

主な危険性  Xi
国連危険物分類  IRRITANT

5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine 価格 もっと(1)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01MAS010287
5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine 		493028-20-9 1g ￥130200 2024-03-01 購入

5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine 化学特性,用途語,生産方法

説明

Core binding factors (CBFs) are heterodimeric transcription factors consisting of a DNA-binding CBFα component (a RUNX protein) and an enhancer of binding, CBFβ. CBF dimers have central roles in hematopoiesis and, when dysfunctional, in leukemias. CBFβ inhibitor is a small molecule that binds to CBFβ and inhibits its association with Runx1 (IC50 = 3.2 μM). It blocks CBFβ-Runx1 interactions in ME-1 cells, acute myeloid leukemia cells harboring dysfunctional CBF, reducing proliferation without toxicity.

使用

Core binding factors (CBFs) are heterodimeric transcription factors consisting of a DNA-binding CBFα component (a RUNX protein) and an enhancer of binding, CBFβ. CBF dimers have central roles in hematopoiesis and, when dysfunctional, in leukemias. CBFβ inhibitor is a small molecule that binds to CBFβ and inhibits its association with Runx1 (IC50 = 3.2 μM). It blocks CBFβ-Runx1 interactions in ME-1 cells, acute myeloid leukemia cells harboring dysfunctional CBF, reducing proliferation without toxicity.

5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine 上流と下流の製品情報

原材料

準備製品

5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine 生産企業

Global( 37)Suppliers
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BOC Sciences 16314854226
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Baoji Didu Pharmaceutical and Chemical Co., Ltd 029-81145305 17791533577
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Nanjing Shizhou Biology Technology Co.,Ltd 025-85560043 15850508050
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  スペクトルデータ(1HNMR)

5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE(493028-20-9)1HNMR

493028-20-9()キーワード:

4-(4-メトキシフェニル)-5-プロピル-1,3-チアゾール-2-アミン 4-(4-エトキシフェニル)-5-プロピル-1,3-チアゾール-2-アミン 4-(4-エトキシフェニル)-5-メチルチアゾール-2-アミン 2-アミノ-5-エチル-4-フェニルチアゾール
  • 493028-20-9
  • TIMTEC-BB SBB011699
  • CBFβ Inhibitor
  • 5-ethyl-4-(4-methoxyphenyl)-1,3-thiazol-2-amine
  • CBFβ Inhibitor - CAS 493028-20-9 - Calbiochem
  • 2-Thiazolamine, 5-ethyl-4-(4-methoxyphenyl)-
  • Runx1-CBFβ interaction inhibitor 1
  • CBFβInhibitor
  • 5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine
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