5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine
- CAS No.
- 493028-20-9
- Chemical Name:
- 5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine
- Synonyms
- CBFβInhibitor;CBFβ Inhibitor;TIMTEC-BB SBB011699;Runx1-CBFβ interaction inhibitor 1;2-Thiazolamine, 5-ethyl-4-(4-methoxyphenyl)-;CBFβ Inhibitor - CAS 493028-20-9 - Calbiochem;5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine;5-ethyl-4-(4-methoxyphenyl)-1,3-thiazol-2-amine
- CBNumber:
- CB0412427
- Molecular Formula:
- C12H14N2OS
- Molecular Weight:
- 234.32
- MDL Number:
- MFCD02232182
- MOL File:
- Mol file
- MSDS File:
- SDS
- TDS File:
- TDS
SAFETY
Risk and Safety Statements
| Hazard Codes | Xi |
|---|---|
| HazardClass | IRRITANT |
5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 16771 | CBFβ Inhibitor ≥98% | 493028-20-9 | 5mg | $80 | 2026-04-30 | Buy |
| Cayman Chemical | 16771 | CBFβ Inhibitor ≥98% | 493028-20-9 | 10mg | $149 | 2026-04-30 | Buy |
| Cayman Chemical | 16771 | CBFβ Inhibitor ≥98% | 493028-20-9 | 25mg | $332 | 2026-04-30 | Buy |
| Biosynth | TUA02820 | 5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine | 493028-20-9 | 250mg | $392.5 | 2026-06-05 | Buy |
| Biosynth | TUA02820 | 5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine | 493028-20-9 | 2.5g | $1386.5 | 2026-06-05 | Buy |
5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine Chemical Properties,Uses,Production
Description
Core binding factors (CBFs) are heterodimeric transcription factors consisting of a DNA-binding CBFα component (a RUNX protein) and an enhancer of binding, CBFβ. CBF dimers have central roles in hematopoiesis and, when dysfunctional, in leukemias. CBFβ inhibitor is a small molecule that binds to CBFβ and inhibits its association with Runx1 (IC50 = 3.2 μM). It blocks CBFβ-Runx1 interactions in ME-1 cells, acute myeloid leukemia cells harboring dysfunctional CBF, reducing proliferation without toxicity.
Uses
Core binding factors (CBFs) are heterodimeric transcription factors consisting of a DNA-binding CBFα component (a RUNX protein) and an enhancer of binding, CBFβ. CBF dimers have central roles in hematopoiesis and, when dysfunctional, in leukemias. CBFβ inhibitor is a small molecule that binds to CBFβ and inhibits its association with Runx1 (IC50 = 3.2 μM). It blocks CBFβ-Runx1 interactions in ME-1 cells, acute myeloid leukemia cells harboring dysfunctional CBF, reducing proliferation without toxicity.
References
[1] KEVIN A. LINK James C M Fu Sheng Chou. Core binding factor at the crossroads: Determining the fate of the HSC[J]. Journal of Cellular Physiology, 2009, 222 1: 50-56. DOI: 10.1002/jcp.21950
[2] GEMMA SWIERS Nancy A S Marella de Bruijn. Hematopoietic stem cell emergence in the conceptus and the role of Runx1.[J]. International Journal of Developmental Biology, 2010, 54 6-7: 1151-1163. DOI: 10.1387/ijdb.103106gs
[3] MICHAEL J GORCZYNSKI. Allosteric inhibition of the protein-protein interaction between the leukemia-associated proteins Runx1 and CBFbeta.[J]. Chemistry & biology, 2007, 14 10: 1186-1197. DOI: 10.1016/j.chembiol.2007.09.006
5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine Preparation Products And Raw materials
Raw materials
Preparation Products
5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9909 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Changzhou Hopschain Chemical Co.,Ltd. | 85528066 13775048983 | sales@hopschem.com | China | 31548 | 55 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8137 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Baoji Didu Pharmaceutical and Chemical Co., Ltd | 029-81145305 17791533577 | 1021@dideu.com | China | 9997 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 11975 | 58 |
View Lastest Price from 5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-04 | CBFβ Inhibitor
493028-20-9
|
$29.00-59.00 | 97.02% | 10g | TargetMol Chemicals Inc. |
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- CBFβ Inhibitor
493028-20-9
- $29.00-59.00
- 97.02%
- TargetMol Chemicals Inc.
