ヒドロキシアセトン 化学特性,用途語,生産方法
外観
無色～うすい黄色, 澄明の液体
溶解性
水に極めて溶けやすく、エタノール及びアセトンに溶ける。
解説
アセトール，ヒドロキシアセトンともいう．ヒドロキシケトンの一種で，ブロモアセトンとギ酸塩から得られるエステルを加水分解して合成される．無色の液体．沸点145～146 ℃．1.0824．1.4295．水，エタノール，エーテルに可溶．アンモニア性硝酸銀，フェーリング液を還元する．
用途
有機合成原料。
化学的特性
colourless to yellow liquid
使用
Hydroxyacetone is a chemical reagent used in various organic chemical reactions. It is a component of the Mannich reaction, amino acid caalyzes direct asymmetric aldol reactions. In the pharmaceutical setting, this compound is used in the synthesis of imidazoles acting as potent and orally active antihypertensive agents. It is also used in the syntheses of 2-oxo-propionaldehyde, imidazoles, polyols, acrolein, dyes and skin tanning agents. It yields (R)-1,2-propanediol upon reduction of hydroxyacetone in the presence of a microbial cell catalyst.
定義
ChEBI: A propanone that is acetone in which one of the methyl hydrogens is replaced by a hydroxy group.
一般的な説明
Hydroxyacetone (Acetol) is important for the manufacture of polyols, acrolein, dyes and skin tanning agents. It undergoes asymmetric reduction to yield (
R)-1,2-propanediol in the presence of microbial cell catalyst.
安全性プロファイル
Moderately toxic by ingestion. Mutation data reported. An allergen. Implicated in aplastic anemia. A 10 gram dose may be fatal to an adult. skin contact, inhalation, or ingestion can cause asthma, sneezing, irritation of eyes and nose, hives, and eczema. Combustible when exposed to heat or flame. When heated to decomposition it emits acrid smoke and fumes.
合成
Hydroxyacetone is produced from Bromoacetone plus sodium formate, followed by Methanol hydrolysis of the formed ester. Or by biochemical synthesis from Propylene glycol with sorbose bacterium.
ヒドロキシアセトン 上流と下流の製品情報
原材料
準備製品