COX-2 (human) Monoclonal Antibody (Clone CX229) 化学特性,用途語,生産方法
説明
Cyclooxygenase 2 (COX-2) is a bifunctional enzyme that exhibits both COX and peroxidase activities and catalyzes the first step in the biosynthesis of prostaglandins, thromboxanes, and prostacyclins. The COX component converts arachidonic acid (Item Nos.
90010 |
90010.1 |
10006607) to the hydroperoxy endoperoxide prostaglandin G
2 (PGG
2; ), and the peroxidase component reduces the endoperoxide to the corresponding alcohol PGH
2 .
COX2 expression is induced by a variety of stimuli, including phorbol esters, LPS, and cytokines and is responsible for the biosynthesis of PGs under acute inflammatory conditions. Thus, COX-2 has been the focus of attention for nonsteroidal anti-inflammatory drug (NSAID) development. Cayman''s COX-2 (human) Monoclonal Antibody (Clone CX229) can be used for immunohistochemistry (IHC) and Western blot (WB) applications. The antibody recognizes a unique C-terminal region of COX-2 that is not present in COX-1, specifically detecting COX-2 ~70 kDa from human and ovine samples.
COX-2 (human) Monoclonal Antibody (Clone CX229) 上流と下流の製品情報
原材料
準備製品