タイランスタチンA

タイランスタチンA 価格

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入

タイランスタチンA 化学特性,用途語,生産方法

説明

Thailanstatin A, a promising lead compound for drug discovery and development efforts, is derived from Thailandensis burkholderia MSMB43. It reveals low nanomolar to subnanomolar cytotoxicity against a variety of human cancer cell lines.

作用機序

The mechanism of action (MOA) of thailanstatin A is the inhibition of spliceosome assembly. Thailanstatin A binds firmly to the SF3b subunit of the U2 snRNA sub-complex, a crucial component of the spliceosome. Since the spliceosomes of cancer cells are more active and exhibits higher mutation rates than those of normal cells, this sub-cellular component is by far the most well-established anti-tumor target in novel drug discoveries.

合成

Thailanstatin A (1): To a stirred solution of epoxide 6 (4.0 mg, 0.012 mmol, 1.0 equiv) and boronate 5 (5.8 mg, 13 |ìmol, 1.1 equiv) in rigorously degassed (freeze-pump-thaw technique3) 3:1:1 1,4-dioxane/MeCN/H2O (0.64 mL,) at 25??C. was added tripotassium phosphate monohydrate (2.8 mg, 0.012 mmol, 1.0 equiv) followed by Pd(dppf)Cl2.CH2Cl2 (0.1 mg, 0.125 |ìmol, 0.025 equiv). After 10 min, the reaction mixture was neutralized with phosphate buffer (NaH2PO4, 1.0 M, 2.5 mL), filtered through a layer of Celite, and rinsed thoroughly with ethyl acetate (20 mL). Then the organic layer was dried with anhydrous sodium sulfate and concentrated in vacuo. The obtained residue was purified by reversed-phase HPLC (C18, |?19150 mm, Atlantis, 40?ú50% aqueous MeCN containing 0.03% TFA) to afford thailanstatin A (1) (ca. 3.0 mg, 6.0 |ìmol, 52%) as a white foam.

タイランスタチンA 上流と下流の製品情報

原材料

準備製品

タイランスタチンA 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5738	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32268	58
Hubei Ipure Biology Co., Ltd	+8613367258412	ada@ipurechemical.com	China	10244	58
Zhejiang Huida Biotech Co., LTD	008613515763466 8615669048680	wendy@huidabiotech.com	CHINA	87	58
Shanghai Minbiotech Co., Ltd.	+8617315815539	sales@minbiotech.com	CHINA	129	58
AFINE CHEMICALS LIMITED	+86-0571-85134551	sales@afinechem.com	China	15417	58
ChemExpress	+86-021-58950125 +86-021-58950125;	info@chemexpress.com	China	784	58
Henan Alfa Chemical Co., Ltd	+8615838112936	alfa10@alfachem.cn	China	13285	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58

1426953-21-0(タイランスタチンA)キーワード:

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• 1426953-21-0
• 1,6-Dioxaspiro[2.5]octane-5-acetic acid, 7-[(1E,3E)-5-[(2S,3S,5R,6R)-5-[[(2Z,4S)-4-(acetyloxy)-1-oxo-2-penten-1-yl]amino]tetrahydro-3,6-dimethyl-2H-pyran-2-yl]-3-methyl-1,3-pentadien-1-yl]-8-hydroxy-, (3R,5S,7R,8R)-
• Thailandstatin A
• Thailanstatin A
• ADC Payload,natural,Inhibitor,inhibit,SF3b,subunit,antiproliferative,Thailanstatin A,spliceosome,ADC,ADC Cytotoxin,RNA,linker
• 6-dioxaspiro[2.5]oct-5-yl]acetic acid
• 2-[(3R,5S,7R,8R)-7-[(1E,3E)-5-[(2S,3S,5R,6R)-5-[(2Z,4S)-4-(acetyloxy)pent-2-enamido]-3,6-dimethyloxan-2-yl]-3-methylpenta-1,3-dien-1-yl]-8-hydroxy-1,6-dioxaspiro[2.5]octan-5-yl]acetic acid
• タイランスタチンA
• (4S)-5α-ヒドロキシ-6β-(5-(3β,6β-ジメチルテトラヒドロ-5β-(1-オキソ-4-メチル-4-(1-オキソエチルオキシ)-2-ブテニルアミノ)-2H-ピラン-2β-イル)-3-メチル-1,3-ペンタジエニル)-4,4-(エポキシメタノ)テトラヒドロ-2H-ピラン2α-酢酸
• 2-[(3S,5S,7R,8R)-7-{5-[(2S,3S,5R,6R)-5-[4-(アセチルオキシ)ペンタ-2-エンアミド]-3,6-ジメチルオキサン-2-イル]-3-メチルペンタ-1,3-ジエン-1-イル}-8-ヒドロキシ-1,6-ジオキサスピロ[2.5]オクタン-5-イル]酢酸