Thailanstatin A
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Thailanstatin A 속성
- 끓는 점
- 757.3±60.0 °C(Predicted)
- 밀도
- 1.23±0.1 g/cm3(Predicted)
- 용해도
- DMSO : 250 mg/mL (466.74 mM; Need ultrasonic)
- 산도 계수 (pKa)
- 4.37±0.10(Predicted)
- 물리적 상태
- Solid
- 색상
- White to off-white
- InChIKey
- GJKQDOMCDFJANR-FUDLAKRJSA-N
- SMILES
- O1[C@@]2([C@H](O)[C@@H](/C=C/C(/C)=C/C[C@@H]3O[C@H](C)[C@H](NC(=O)/C=C\[C@@H](OC(C)=O)C)C[C@@H]3C)O[C@H](CC(O)=O)C2)C1
안전
Thailanstatin A C화학적 특성, 용도, 생산
개요
Thailanstatin A, a promising lead compound for drug discovery and development efforts, is derived from Thailandensis burkholderia MSMB43. It reveals low nanomolar to subnanomolar cytotoxicity against a variety of human cancer cell lines.Mechanism of action
The mechanism of action (MOA) of thailanstatin A is the inhibition of spliceosome assembly. Thailanstatin A binds firmly to the SF3b subunit of the U2 snRNA sub-complex, a crucial component of the spliceosome. Since the spliceosomes of cancer cells are more active and exhibits higher mutation rates than those of normal cells, this sub-cellular component is by far the most well-established anti-tumor target in novel drug discoveries.Synthesis
Thailanstatin A (1): To a stirred solution of epoxide 6 (4.0 mg, 0.012 mmol, 1.0 equiv) and boronate 5 (5.8 mg, 13 |ìmol, 1.1 equiv) in rigorously degassed (freeze-pump-thaw technique3) 3:1:1 1,4-dioxane/MeCN/H2O (0.64 mL,) at 25C. was added tripotassium phosphate monohydrate (2.8 mg, 0.012 mmol, 1.0 equiv) followed by Pd(dppf)Cl2.CH2Cl2 (0.1 mg, 0.125 |ìmol, 0.025 equiv). After 10 min, the reaction mixture was neutralized with phosphate buffer (NaH2PO4, 1.0 M, 2.5 mL), filtered through a layer of Celite, and rinsed thoroughly with ethyl acetate (20 mL). Then the organic layer was dried with anhydrous sodium sulfate and concentrated in vacuo. The obtained residue was purified by reversed-phase HPLC (C18, |19150 mm, Atlantis, 40ú50% aqueous MeCN containing 0.03% TFA) to afford thailanstatin A (1) (ca. 3.0 mg, 6.0 |ìmol, 52%) as a white foam.
Thailanstatin A 준비 용품 및 원자재
원자재
준비 용품
Thailanstatin A 공급 업체
글로벌( 62)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Zhejiang Huida Biotech Co., LTD | 0571-89903022 18679456698 |
zilong@hizyme.com | China | 8001 | 58 |
| Chembest Research Laboratories Limited | 021-20908456 |
sales@BioChemBest.com | China | 5996 | 61 |
| T&W GROUP | 021-61551611 13296011611 |
contact@trustwe.com | China | 9884 | 58 |
| Nanjing Sunlida Biological Technology Co., Ltd. | 025-57798810 18652991625 |
sales@sunlidabio.com | China | 3223 | 55 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 |
3003855609@qq.com | China | 7690 | 56 |
| Taizhou KEDE Chemical Co., Ltd | 0576-84613060 13093829633;13736603231; |
sales@kedechemical.com | China | 299 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 |
info@efebio.com | China | 9799 | 58 |
| Wellman Pharmaceutical Group Limited | 15807197853 18971451745 |
15807197853@163.com | China | 3981 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1059@dideu.com | China | 29086 | 58 |
| Henan Alfa Chemical Co., Ltd | +8618339805032 |
sale03@alfachem.cn | China | 9872 | 58 |
Thailanstatin A 관련 검색:
Thailanstatin C
Thailanstatin D
Thailanstatin B
(3R,5S,7R,8R)-7-[(1E,3E)-5-[(2S,3S,5R,6R)-5-[[(2Z,4S)-4-(Acetyloxy)-1-oxo-2-penten-1-yl]amino]tetrahydro-3,6-dimethyl-2H-pyran-2-yl]-3-methyl-1,3-pentadien-1-yl]-N-[5-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)pentyl]-8-hydroxy-1,6-dioxaspiro[2.5]octane-5-acetamide
FR901465
Sudemycin E