10-Hydroxycamptothecin
10-Hydroxycamptothecin 物理性質
- 融点 :
- 230-237°C
- 沸点 :
- 820.7±65.0 °C(Predicted)
- 比重(密度) :
- 1.60
- 貯蔵温度 :
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- 溶解性:
- DMSO: ≥ 37.5 mg/mL (102.92 mM)
- 酸解離定数(Pka):
- 8.93±0.40(Predicted)
- 外見 :
- 薄黄色の粉末
- 色:
- Yellow
- InChI:
- InChI=1S/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3
- InChIKey:
- LCZZWLIDINBPRC-FQEVSTJZSA-N
- SMILES:
- N1C2C(=CC(O)=CC=2)C=C2CN3C(C=12)=CC1C(CC)(O)C(=O)OCC=1C3=O
- CAS データベース:
- 64439-81-2(CAS DataBase Reference)
10-Hydroxycamptothecin 価格
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10-Hydroxycamptothecin 化学特性,用途語,生産方法
説明
10-Hydroxycamptothecin: An Inhibitor of Topoisomerase I with Antitumor Activity
10-hydroxycamptothecin (10-HCPT) is an inhibitor of topoisomerase I originally isolated from the Chinese tree C. acuminata. 10-HCPT, a member of the camptothecin family, interferes with DNA synthesis by inhibiting the enzyme topoisomerase-I and has a broad spectrum of antitumor activity and less toxicity as camptothecins. However, 10-HCPT is insoluble in both water and physiological acceptable organic solvents and tends to change into its carboxylate form, which shows minimal antitumor activity and several unpredictable side effects. Therefore, appropriate drug delivery systems (DDS) for 10-HPCT have been developed to improve the stability of its lactone form. 10-HCPT is also an important precursor for the synthesis of clinically useful anticancer agents, such as irinotecan[1].
化学的特性
mp 268-270°C loss on drying <1%
使用
Topoisomerase inhibitor
参考文献
[1] Chunjian Zhao. “Determination of Camptothecin and 10-Hydroxycamptothecin in Camptotheca acuminata by LC-ESI-MS/MS.” Analytical Letters 6 1 (2010): 2681–2693.
[2] Ruonan Shuang. “Pharmacokinetics of 10-hydroxycamptothecin–tetrandrine liposome complexes in rat by a simple and sensitive ultra-high performance liquid chromatography with tandem mass spectrometry.” Journal of separation science 43 3 (2019): 569–576.
10-Hydroxycamptothecin 上流と下流の製品情報
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10-Hydroxycamptothecin 生産企業
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64439-81-2()キーワード:
- 64439-81-2
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- (Inverted exclamation markA)-10-Hydroxycamptothecin
- 4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
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